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Dorsal Motor Nucleus of Vagus protein aggregates in Lewy Body Disease with autonomic dysfunction

Lookup NU author(s): Veronica Miller, Professor Rose Anne Kenny, Arthur Oakley, Roslyn Hall, Professor Raj KalariaORCiD, Dr Louise Allan

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Abstract

The Dorsal Motor Nucleus of Vagus (DMV) is degenerated in many patients with early stage Lewy Body Diseases (LBD). Many patients with LBD also develop symptomatic autonomic dysfunction prior to motor and cognitive symptoms. The DMV, along with the Nucleus Ambiguous (NA) and Raphe Obscurus (RO) regulates a variety of autonomic reflexes, suggesting that there may be an association between the degree of neurodegenerative protein aggregation in the DMV and symptomatic autonomic dysfunction in patients with LBD. Using digital in vivo pathology, we quantified alpha synuclein, tau, ubiquitin and Heat Shock Protein 27 (HSP27) containing neurons in the DMV, NA, RO, in addition to the hypoglossal nucleus in 12 LBD patients. alpha Synuclein, ubiquitin and tau aggregates most greatly affected the DMV followed by the NA, RO, but never the hypoglossal nucleus. There was a positive correlation between DMV alpha synuclein and tau aggregation (p

Publication metadata

Author(s): Miller VM, Kenny RA, Oakley AE, Hall R, Kalaria RN, Allan LM

Publication type: Article

Publication status: Published

Journal: Brain Research

Year: 2009

Volume: 1286

Pages: 165-173

ISSN (print): 0006-8993

ISSN (electronic): 1872-6240

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/j.brainres.2009.05.083

DOI: 10.1016/j.brainres.2009.05.083

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