Publications by Dr Rachel Lakey - ePrints

Browsing publications by Dr Rachel Lakey.

Newcastle Authors	Title	Year
Dr Miranda Patterson Dr Nina Wilson Tara Homer Laura Simms Dr Alison Steel et al.	Dual bronchodilators in Bronchiectasis study (DIBS): protocol for a pragmatic, multicentre, placebo-controlled, three-arm, double-blinded, randomised controlled trial studying bronchodilators in preventing exacerbations of bronchiectasis	2023
Dr Alaa Abouhajar Dr Lisa Alcock Dr Theophile Bigirumurame Penny Bradley Laura Brown et al.	Acipimox in Mitochondrial Myopathy (AIMM): study protocol for a randomised, double-blinded, placebo-controlled, adaptive design trial of the efficacy of acipimox in adult patients with mitochondrial myopathy	2022
Professor Phil White Dr Barbara Gregson Dr Adela Cora Dr Anand Dixit Dr Rachel Lakey et al.	Evaluation of stroke thrombectomy including patients where IV thrombolysis is contraindicated or has failed: A randomized trial of two novel thrombectomy devices	2021
Professor Christopher Price Dr Lisa Shaw Dr Mehdi Javanbakht Dr Peter McMeekin Dr Darren Flynn et al.	Effect of an Enhanced Paramedic Acute Stroke Treatment Assessment (PASTA) on Thrombolysis Delivery During Emergency Stroke Care: A Cluster Randomised Clinical Trial	2020
Professor Christopher Price Dr Lisa Shaw Professor Catherine Exley Dr Darren Flynn Emeritus Professor Roger Francis et al.	Paramedic Acute Stroke Treatment Assessment (PASTA): study protocol for a randomised controlled trial	2019
Professor Christopher Price Dr Stuart Huntley Dr Rachel Lakey	Estimated GFR and the Effect of Intensive Blood Pressure Lowering after Acute Intracerebral Hemorrhage	2016
Professor Phil White Dr Rachel Lakey	Observer Reliability of CT Angiography in the assessment of acute ischaemic stroke: Data from the Third International Stroke Trial	2015
Mark Houseman Dr Kate Potter Nicola Marshall Dr Rachel Lakey Emeritus Professor Tim Cawston et al.	Baseline serum MMP-3 levels in patients with Rheumatoid Arthritis are still independently predictive of radiographic progression in a longitudinal observational cohort at 8 years follow up	2012
Professor Phil White Dr Rachel Lakey	The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): A randomised controlled trial	2012
Dr Kenneth Rankin Dr Rachel Lakey Craig Gerrand Andrew Sprowson Professor Andrew McCaskie et al.	A Novel in Vitro Model to Investigate Behavior of Articular Chondrocytes in Osteoarthritis	2010
Emeritus Professor Tim Cawston Dr Rachel Lakey Emeritus Professor Drew Rowan	Assay of matrix metalloproteinases against matrix substrates	2010
Dr Matthew Barter Dr Rachel Lakey Dr Jonathan Catterall Emeritus Professor Tim Cawston Professor David Young et al.	Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation	2010
Dr Rachel Lakey Emeritus Professor Drew Rowan Professor John Isaacs Emeritus Professor Tim Cawston Professor Catharien Hilkens et al.	A novel paradigm for dendritic cells as effectors of cartilage destruction	2009
Dr Rachel Lakey Emeritus Professor Tim Cawston	Sulfasalazine blocks the release of proteoglycan and collagen from cytokine stimulated cartilage and down-regulates metalloproteinases	2009
Dr Kenneth Rankin Dr Rachel Lakey Craig Gerrand Andrew Sprowson Professor Andrew McCaskie et al.	A novel in vitro model of osteoarthritis facilitates improved understanding of human articular chondrocyte behaviour	2008
Dr Kenneth Rankin Craig Gerrand Dr Rachel Lakey Andrew Sprowson Professor Andrew McCaskie et al.	Hypoxia facilitates bone invasion by increasing breast cancer cell expression of matrix metalloproteinase-1	2008
Dr Gary Litherland Dr Craig Dixon Dr Rachel Lakey Tim Robson David Jones et al.	Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent	2008
Emeritus Professor Tim Cawston Dr Rachel Lakey Debra Jones Dr Jonathan Catterall Emeritus Professor Robin Seymour et al.	Gingival fibroblasts grown from cyclosporin-treated patients show a reduced production of matrix metalloproteinase-1 (MMP-1) compared with normal gingival fibroblasts, and cyclosporin down-regulates the production of MMP-1 stimulated by pro-inflammatory cytokines	2007
Dr Jonathan Catterall Dr Rachel Lakey Emeritus Professor Tim Cawston	Investigation into the potential chondroprotective effects of ciclosporin in arthritis	2006
Dr Emma Barksby Dr Jenny Milner Dr Angela Patterson Dr Nicholas Peake Tim Robson et al.	Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: Implications for cartilage degradation in arthritis	2006
Dr Rachel Lakey Dr Jonathan Catterall Emeritus Professor Tim Cawston	Mevastatin and simvastatin block collagen release from bovine cartilage and downregulate MMP-13 from human articular chondrocytes	2006
Professor David Young Dr Rachel Lakey Professor David Jones Emeritus Professor Tim Cawston	Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption	2005
Professor David Young Dr Rachel Lakey David Jones Emeritus Professor Tim Cawston	Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption	2005
Professor David Young Dr Rachel Lakey David Jones Emeritus Professor Tim Cawston	Oncostatin M in combination with tumour necrosis factor alpha induces a chondrocyte membrane-associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2	2005
Professor David Young Dr Rachel Lakey Emeritus Professor Tim Cawston	Histone deacetylase inhibitors are chondroprotective	2004
Dr Andrea Myers Dr Rachel Lakey Emeritus Professor Tim Cawston Dr Lesley Kay	Serum MMP-1 and TIMP-1 levels are increased in patients with psoriatic arthritis and their siblings	2004