Publications by Professor Steven Clifford - ePrints

Browsing publications by Professor Steven Clifford.

Newcastle Authors	Title	Year
Professor Steven Clifford	Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage	2024
Professor Steven Clifford	Correction to: Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage (Nature Communications, (2024), 15, 1, (269), 10.1038/s41467-023-44117-x)	2024
Jemma Castle Dr Ed Fielder Mankaran Singh Professor Roderick Skinner Professor Thomas von Zglinicki et al.	In vivo modeling recapitulates radiotherapy delivery and late-effect profile for childhood medulloblastoma	2024
Dr Claire Keeling Dr Jack Goddard Dr Ed Schwalbe Professor Simon Bailey Dr Debbie Hicks et al.	MDB-31. The clinical significance of sub-total surgical resection in childhood medulloblastoma: a multi-cohort analysis of 1100 patients.	2024
Dr Marion Mateos Dr Daniel Williamson Dr Marina Danilenko Dr Jack Goddard Dr Stephen Crosier et al.	MDB-64. Novel transcripts associate with survival in childhood medulloblastoma.	2024
Dr Florence Burté Magretta Adiamah Dr Fatma Scerif Dr Debbie Hicks Dr Ed Schwalbe et al.	Metabolite profiles of medulloblastoma for rapid and non-invasive detection of molecular disease groups	2024
Dr Claire Keeling Dr Jack Goddard Dr Ed Schwalbe Professor Simon Bailey Dr Debbie Hicks et al.	The clinical significance of sub-total surgical resection in childhood medulloblastoma: a multi-cohort analysis of 1100 patients	2024
Dr Stacey Richardson Dean Thompson Professor Steven Clifford Dr Rebecca Hill	ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors	2023
Professor Steven Clifford Dr Ed Schwalbe	Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome	2023
James Hacking Dr Dean Thompson Dr Ed Schwalbe Professor Steven Clifford Dr Daniel Williamson et al.	Deriving a continuum score for group 3 and 4 medulloblastoma tumor samples analyzed via RNA-sequencing or DNA methylation microarray	2023
Professor Steven Clifford	Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging	2023
Dr Jack Goddard Jemma Castle Emily Southworth Anya Fletcher Dr Stephen Crosier et al.	Molecular characterisation defines clinically-actionable heterogeneity within Group 4 medulloblastoma and improves disease risk-stratification	2023
Professor Simon Bailey Professor Steven Clifford	Outcomes of Infants and Young Children With Relapsed Medulloblastoma After Initial Craniospinal Irradiation-Sparing Approaches: An International Cohort Study	2023
Dr Daniel Williamson Dr Ed Schwalbe Professor Simon Bailey Professor Steven Clifford	Timing is everything: A connection between medulloblastoma prognosis and foetal cerebellar development	2023
Dr Daniel Williamson Professor Steven Clifford	Beta-blockers disrupt mitochondrial bioenergetics and increase radiotherapy efficacy independently of beta-adrenergic receptors in medulloblastoma	2022
Dr Stacey Richardson Professor Steven Clifford	Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation	2022
Dr Stacey Richardson Dr Rebecca Hill Professor Steven Clifford	Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma	2022
Professor Simon Bailey Professor Steven Clifford	How Can Genomic Innovations in Pediatric Brain Tumors Transform Outcomes in Low- and Middle-Income Countries?	2022
Dr Jack Goddard Jemma Castle Emily Southworth Anya Fletcher Dr Stephen Crosier et al.	MEDB-71. Molecular characterisation of Group 4 medulloblastoma improves risk-stratification and its biological understanding	2022
Dr Daniel Williamson Dr Ed Schwalbe Dr Debbie Hicks Dr Janet Lindsey Dr Stephen Crosier et al.	Medulloblastoma group 3 and 4 tumors comprise a clinically and biologically significant expression continuum reflecting human cerebellar development	2022
Dr Rebecca Hill Professor Steven Clifford Professor Simon Bailey	Relapsed medulloblastoma in pre-irradiated patients: Current practice for diagnostics and treatment	2022
Dr Marina Danilenko Dr Claire Keeling Dr Stephen Crosier Dr Martina Finetti Dr Daniel Williamson et al.	Single-cell DNA sequencing identifies risk-associated clonal complexity and evolutionary trajectories in childhood medulloblastoma development	2022
Professor Simon Bailey Professor Steven Clifford	Acceptance and commitment therapy for young brain tumour survivors: Study protocol for an acceptability and feasibility trial	2021
Dr Stephen Crosier Dr Debbie Hicks Dr Ed Schwalbe Dr Daniel Williamson Amanda Smith et al.	Advanced molecular pathology for rare tumours: A national feasibility study and model for centralised medulloblastoma diagnostics	2021
Professor Simon Bailey Professor Steven Clifford Dr Dipayan Mitra	Combining multi-site magnetic resonance imaging with machine learning predicts survival in pediatric brain tumors	2021
Professor Steven Clifford	Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation	2021
Dr Marina Danilenko Professor Steven Clifford Dr Ed Schwalbe	Inter and intra-tumoral heterogeneity as a platform for personalized therapies in medulloblastoma	2021
Professor Steven Clifford	SIOP PNET5 MB trial: History and concept of a molecularly stratified clinical trial of risk-adapted therapies for standard-risk medulloblastoma	2021
Dr Debbie Hicks Dr Reza Rafiee Dr Ed Schwalbe Dr Christopher Howell Dr Janet Lindsey et al.	The molecular landscape and associated clinical experience in infant medulloblastoma: prognostic significance of second-generation subtypes	2021
Dr Ed Schwalbe Dr Debbie Hicks Professor Steven Clifford	Effects of the growth pattern of medulloblastoma on short-term neurological impairments after surgery: Results from the prospective multicenter HIT-SIOP PNET 4 study	2020
Dr Matthew Selby Dr Daniel Williamson Professor Steven Clifford	Erratum: Author Correction: VEGFC negatively regulates the growth and aggressiveness of medulloblastoma cells (Communications biology (2020) 3 1 (579))	2020
Professor Steven Clifford	Evaluation of Prognostic Factors and Role of Participation in a Randomized Trial or a Prospective Registry in Pediatric and Adolescent Nonmetastatic Medulloblastoma – A Report From the HIT 2000 Trial	2020
Dr Yura Grabovska Dr Stephen Crosier Dr Martina Finetti Dr Ed Schwalbe Dr Rebecca Hill et al.	Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity	2020
Dr Rebecca Hill Dr Stacey Richardson Dr Ed Schwalbe Dr Debbie Hicks Dr Janet Lindsey et al.	Time, pattern, and outcome of medulloblastoma relapse and their association with tumour biology at diagnosis and therapy: a multicentre cohort study	2020
Professor Steven Clifford	VEGFC negatively regulates the growth and aggressiveness of medulloblastoma cells	2020
Dr Rebecca Hill Professor Steven Clifford Yura Grabovska Dr Daniel Williamson	DNA methylation-based profiling for paediatric CNS tumour diagnosis and treatment: a population-based study	2019
Professor Steven Clifford Dr Ed Schwalbe Dr Debbie Hicks	Imaging Characteristics of Wingless Pathway Subgroup Medulloblastomas: Results from the German HIT/SIOP-Trial Cohort	2019
Professor Steven Clifford Professor David Ellison	Medulloblastoma	2019
Dr Ed Schwalbe Dr Daniel Williamson Dr Janet Lindsey Dr Rebecca Hill Dr Debbie Hicks et al.	Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes	2019
Dr Daniel Williamson Dr Christopher Jones Professor Steven Clifford	Biological material collection to advance translational research and treatment of children with CNS tumours: position paper from the SIOPE Brain Tumour Group	2018
Dr Ed Schwalbe Dr Debbie Hicks Professor Steven Clifford	Prognostic impact of whole chromosomal 1 aberration signatures in standard-risk non-WNT/non-SHH medulloblastoma: a retrospective molecular analysis of the HIT-SIOP-PNET4 clinical trial	2018
Professor Steven Clifford Dr Debbie Hicks Dr Janet Lindsey Dr Rebecca Hill	Development of a targeted sequencing approach to identify prognostic, predictive and diagnostic markers in paediatric solid tumours	2017
Dr Ed Schwalbe Dr Debbie Hicks Dr Reza Rafiee Dr Matthew Bashton Dr Amir Enshaei et al.	Minimal methylation classifier (MIMIC): A novel method for derivation and rapid diagnostic detection of disease-associated DNA methylation signatures	2017
Dr Ed Schwalbe Dr Janet Lindsey Dr Sirintra Nakjang Dr Stephen Crosier Amanda Smith et al.	Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study	2017
Dr Matthew Selby Dr Daniel Williamson Professor Steven Clifford	TAp73 is a marker of glutamine addiction in medulloblastoma	2017
Dr Stephen Crosier Dr Debbie Hicks Dr Ed Schwalbe Dr Daniel Williamson Sarah Nicholson et al.	Centralised Molecular Pathology for Rare Tumours: A National Feasibility Study of Real-Time Medulloblastoma Diagnostics	2016
Professor Steven Clifford	Distinct Gene Fusions Segregate Sub-Classes of CNS-PNETs	2016
Professor Simon Bailey Dr Janet Lindsey Professor Steven Clifford	Divergent clonal selection dominates medulloblastoma at recurrence	2016
Professor Steven Clifford Dr Stephen Crosier Dr Debbie Hicks Stewart Nicholson Dr Nicholas Bown et al.	Establishment of national real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma (MB)	2016
Professor Steven Clifford	Evaluation of age-dependent treatment strategies for children and young adults with pineoblastoma: analysis of pooled SIOP-E and head start data	2016
Dr Ed Schwalbe Dr Debbie Hicks Professor Steven Clifford	Health-Related Quality of Life (HRQoL) in HIT-SIOP-PNET4 trial survivors: differences between medulloblastoma molecular subgroups	2016
Professor Steven Clifford	Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours	2016
Dr Debbie Hicks Dr Ed Schwalbe Dr Stephen Crosier Professor Simon Bailey Dr Daniel Williamson et al.	Identification of medulloblastoma molecular subgroups using metabolite profiles	2016
Dr Martina Finetti Matthew Selby Dr Matthew Bashton Dr Ruth Cranston Dr Stephen Crosier et al.	Integrated pathway analysis of malignant rhabdoid tumour identifies key SMARCB1-pathways and therapeutic opportunities	2016
Dr Martina Finetti Alicia Del Carpio Pons James Barker James Wood Dr Sirintra Nakjang et al.	Integrated pathway analysis of rhabdoid tumor subtypes identifies key SMARCB1-dependencies and therapeutic opportunities	2016
Matthew Selby Dr Martina Finetti Dr Matthew Bashton Dr Ruth Cranston Alicia Del Carpio Pons et al.	Investigating the biology of atypical teratoid/rhabdoid tumors by whole genome CRISPR/CAS9 screening	2016
Dr Janet Lindsey Dr Rebecca Hill Dr Ed Schwalbe Dr Christopher Howell Dr Reza Rafiee et al.	Molecular and Prognostic Heterogeneity within MYC and MYCN Amplified Medulloblastomas	2016
Dr Debbie Hicks Professor Steven Clifford	Molecular Subgrouping of Medulloblastoma with nanostring technology: A feasibility study for routine real-time procedures	2016
Professor Steven Clifford	Relapse patterns and outcome after relapse in standard risk medulloblastoma: a report from the HIT-SIOP-PNET4 study	2016
Professor Simon Bailey Professor Steven Clifford	Risk stratification of childhood medulloblastoma in the molecular era: the current consensus	2016
Dr Ed Schwalbe Dr Debbie Hicks Dr Reza Rafiee Dr Matthew Bashton Dr Amir Enshaei et al.	Routine Diagnostic Medulloblastoma Subgrouping Using Low-Cost, Low-Input DNA Methylomics: Application to Trials Cohorts Previously Refractory-to-Analysis	2016
Dr Ed Schwalbe Dr Debbie Hicks Dr Reza Rafiee Dr Matthew Bashton Dr Amir Enshaei et al.	Routine molecular subgrouping of medulloblastoma: Bridging the divide between research and the clinic using low-cost, mass spectrometry-based DNA methylomics	2016
Dr Debbie Hicks Dr Reza Rafiee Dr Ed Schwalbe Dr Christopher Howell Dr Janet Lindsey et al.	Subgroup-Directed Stratification of Risk in Infant Medulloblastoma	2016
Dr Daniel Williamson Dr Janet Lindsey Dr Debbie Hicks Dr Stephen Crosier Amanda Smith et al.	The Transcriptional Landscape of Medulloblastoma: Group 3 and Group 4 Tumours Comprise a Single Clinically Significant Expression Continuum	2016
Professor Steven Clifford Dr Ed Schwalbe Dr Debbie Hicks Kieran O'Toole Sarah Nicholson et al.	Biomarker-driven stratification of disease-risk in non-metastatic medulloblastoma: Results from the multi-center HIT-SIOP-PNET4 clinical trial	2015
Professor Steven Clifford Dr Ed Schwalbe Dr Debbie Hicks Kieran O'Toole Sarah Nicholson et al.	Biomarker-driven stratification of disease-risk in non-metastatic medulloblastoma: Results from the multi-center HIT-SIOP-PNET4 clinical trial	2015
Dr Rebecca Hill Dr Janet Lindsey Dr Ed Schwalbe Dr Karen Barker Dr Daniel Williamson et al.	Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease	2015
Dr Janet Lindsey Dr Ed Schwalbe Matthew Selby Dr James Hayden Dr Daniel Williamson et al.	Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance	2015
Dr Ed Schwalbe Professor Steven Clifford	DNA Methylation Analysis of Paediatric Low-Grade Astrocytomas Identifies a Tumour-Specific Signature at a Set of Enhancers	2015
Dr Al Gabriel Fadhel Alsaid Naji Dr Ed Schwalbe Dr Sirintra Nakjang Dr Simon Cockell et al.	Epigenetic landscape correlates with genetic subtype but does not predict outcome in childhood acute lymphoblastic leukemia	2015
Dr Janet Lindsey Dr Ed Schwalbe Sandeep Potluri Professor Simon Bailey Dr Daniel Williamson et al.	TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours	2014
Dr Martina Finetti Alicia Del Carpio Pons Ben Skalkoyannis Matthew Selby Amanda Smith et al.	A Systems Biology Approach to Identify Mechanism of Tumourigenesis Caused by Loss of SMARCB1 in Malignant Rhabdoid Tumors (BACR28)	2014
Professor Simon Bailey Professor David Ellison Professor Steven Clifford	An Exploration of Associations between Health Related Quality of Life and Medulloblastoma Molecular Subgroup Status in Survivors from the SIOP UKCCSG PNET3 Trial	2014
Dr Martina Finetti Matthew Selby Dr Stephen Crosier Ben Skalkoyannis Professor Simon Bailey et al.	Characterising critical pathways in ATRT tumourigenesis: a genome-wide analysis of primary tumours and functional genomic models	2014
Professor Steven Clifford	CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity	2014
Dr Janet Lindsey Dr Ed Schwalbe Dr James Hayden Professor David Ellison Dr Daniel Williamson et al.	Cross-Species Epigenetics Identifies a Critial Role for VAV1 in the Maintenance of Sonic Hedgehog Subgroup Medulloblastomas	2014
Professor Simon Bailey Dr Janet Lindsey Professor Steven Clifford	Cytogenetic Prognostication Within Medulloblastoma Subgroups	2014
Professor Steven Clifford	Epigenetic repression of the dopamine receptor D4 in pediatric tumors of the central nervous system	2014
Professor Simon Bailey Professor David Ellison Professor Steven Clifford	Improved health-related quality of life outcomes associated with SHH subgroup medulloblastoma in SIOP-UKCCSG PNET3 trial survivors	2014
Dr Martina Finetti Ben Skalkoyannis Matthew Selby Dr Stephen Crosier Professor Simon Bailey et al.	Mechanism of tumourigenesis caused by loss of SMARCB1 in malignant rhabdoid tumors	2014
Professor Simon Bailey Professor Steven Clifford Dr Daniel Williamson	Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group	2014
Dr Rebecca Hill Dr Janet Lindsey Dr Ed Schwalbe Dr Daniel Williamson Dr Sarra Ryan et al.	MYC and TP53 defects emerge and interact at medulloblastoma relapse, define rapidly progressive disease and can be targeted therapeutically	2014
Dr Rebecca Hill Dr Janet Lindsey Dr Ed Schwalbe Dr Karen Barker Dr Daniel Williamson et al.	MYC and TP53 defects interact at medulloblastoma relapse to define rapidly progressive disease and can be targeted therapeutically	2014
Dr Martina Finetti Matthew Selby Alicia Del Carpio Pons Ben Skalkoyannis Amanda Smith et al.	Next-generation sequencing identifies the mechanism of tumourigenesis caused by loss of SMARCB1 in malignant rhabdoid tumours	2014
Professor Steven Clifford	Prognostic Factors in Childhood CNS-PNET and Pineblastoma: An International Meta-Analysis of Original Clinical Data	2014
Dr Ed Schwalbe Dr Debbie Hicks Dr Reza Rafiee Dr Amir Enshaei Sandeep Potluri et al.	Routine molecular subgrouping of medulloblastoma: Bridging the divide between research and the clinic using low-cost DNA methylomics	2014
Professor Steven Clifford	WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma	2014
Professor Steven Clifford Dr Stephen Crosier Sarah Nicholson Dr Nicholas Bown	A national feasibility study of real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma	2013
Dr Ed Schwalbe Dr Daniel Williamson Dr Janet Lindsey Dolores Hamilton Sarra Ryan et al.	DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies	2013
Dr Ed Schwalbe Dr James Hayden Dr Janet Lindsey Dr Rebecca Hill Sarah Nicholson et al.	Histologically defined central nervous system primitive neuro-ectodermal tumours (CNS-PNETs) display heterogeneous DNA methylation profiles and show relationships to other paediatric brain tumour types	2013
Dr Maria Lastowska Hani Al-Afghani Haya AL-Balool Harsh SHETH Dr Jonathan Coxhead et al.	Identification of a neuronal transcription factor network involved in medulloblastoma development	2013
Dr Matthew Allen Dr Daniel Williamson Professor Steven Clifford	Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells	2013
Dr Rebecca Hill Dr Janet Lindsey Dr Ed Schwalbe Professor Simon Bailey Professor Steven Clifford et al.	Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma	2013
Dr Sarra Ryan Dr Ed Schwalbe Mike Cole Yuan Lu Dr Meryl Lusher et al.	MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma	2012
Dr Stephen Crosier Sarah Nicholson Dr Nicholas Bown Professor Steven Clifford	A National Feasibility Study of Real-Time Central Pathology Review and Molecular Diagnostics for Medulloblastoma	2012
Dr Daniel Williamson Professor Steven Clifford	A significant proportion of medulloblastoma do not sub-group robustly: Identification of a molecular NOS (not otherwise specified) subgroup	2012
Dr Daniel Williamson Professor Steven Clifford	Biological and clinical heterogeneity of MYCN-amplified medulloblastoma	2012
Professor Steven Clifford	Cancer Genetics: Evolution after tumour spread	2012
Professor Steven Clifford	Delineating the genomic differences between primary and recurrent medulloblastoma	2012
Dr Daniel Williamson Professor Steven Clifford	Dissecting the genomic complexity underlying medulloblastoma	2012
Dr Ed Schwalbe Dr Janet Lindsey Dr Daniel Williamson Kieran O'Toole Dr Meryl Lusher et al.	Epigenetic sub-classification and risk-stratification of medulloblastoma using DNA methylomics	2012
Professor Steven Clifford	Hyperfractionated Versus Conventional Radiotherapy Followed by Chemotherapy in Standard-Risk Medulloblastoma: Results From the Randomized Multicenter HIT-SIOP PNET 4 Trial	2012
Dr James Hayden Dr Christopher Jones Professor Steven Clifford	Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis	2012
Professor Steven Clifford Professor David Ellison Dr Richard Gilbertson	Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas	2012
Professor Steven Clifford Professor David Ellison Dr Richard Gilbertson	Molecular subgroups of medulloblastoma: the current consensus	2012
Professor Steven Clifford	Polo-Like Kinase 1 (PLK1) Inhibition Reduces Cell Proliferation and Induces Apoptosis in Childhood Acute Lymphoblastic Leukemia	2012
Professor Steven Clifford	Prognostic and therapeutic role of TP53 mutations in medulloblastoma subgroups; therapeutic role of lithium in abrogation of TP53 mutation associated radiation resistance	2012
Dr Janet Lindsey Professor Simon Bailey Professor Steven Clifford	Subgroup-specific structural variation across 1,000 medulloblastoma genomes	2012
Dr Ed Schwalbe Professor Steven Clifford	Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death	2012
Dr Jonathan Fisher Lisa Price Dr Juliet Hale Professor Steven Clifford Professor Simon Bailey et al.	The importance of biopsy following radiological diagnosis of relapsed medulloblastoma	2012
Sarah Nicholson Dr Nicholas Bown Professor Steven Clifford	A feasibility study of real-time central pathology review (CPR) and molecular diagnostics for medulloblastoma in the United Kingdom	2011
Professor David Ellison Dr Hisham Megahed Dr Meryl Lusher Dr Sarra Ryan Professor Simon Bailey et al.	Definition of Disease-Risk Stratification Groups in Childhood Medulloblastoma Using Combined Clinical, Pathologic, and Molecular Variables	2011
Dr Ed Schwalbe Professor Steven Clifford	Genome-Wide Analysis of Alternative Splicing in Medulloblastoma Identifies Splicing Patterns Characteristic of Normal Cerebellar Development	2011
Dr Vikki Rand Professor Steven Clifford Dr James Hayden	Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma	2011
Professor Steven Clifford	Medulloblastoma Comprises Four Distinct Molecular Variants	2011
Professor David Ellison Sarah Nicholson Professor Simon Bailey Professor Steven Clifford Dr Richard Gilbertson et al.	Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups	2011
Dr Ed Schwalbe Professor Steven Clifford	Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance	2011
Professor Steven Clifford	Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct	2011
Dr Ed Schwalbe Dr Janet Lindsey Debbie Straughton Mike Cole Dr Hisham Megahed et al.	Rapid Diagnosis of Medulloblastoma Molecular Subgroups	2011
Dr Meryl Lusher Dr Janet Lindsey Professor Steven Clifford	RASSF1A and the BH3-only mimetic ABT-737 promote apoptosis in pediatric medulloblastoma cell lines	2011
Dr Janet Lindsey Dr Rebecca Hill Dr Hisham Megahed Dr Meryl Lusher Dr Ed Schwalbe et al.	TP53 Mutations in Favorable-Risk Wnt/Wingless-Subtype Medulloblastomas	2011
Rachel Daniel Dr Agata Rozanska Dr Evan Mulligan Dr Yvette Drew Huw Thomas et al.	Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699	2010
Dr Ed Schwalbe Professor Steven Clifford Dr Richard Gilbertson	Characteristic Genomic Imbalances in Paediatric Ependyoma; The Importance of Chromosome 1Q Gain	2010
Dr Hisham Megahed Dr Sarra Ryan Dr Meryl Lusher Sarah Nicholson Professor Simon Bailey et al.	Clinical, Pathological, and Molecular Variables Define Risk-Stratification Groups in Childhood Medulloblastoma	2010
Professor David Ellison Dr Hisham Megahed Dr Sarra Ryan Dr Meryl Lusher Sarah Nicholson et al.	Clinical, pathological, and molecular variables define risk-stratification groups in childhood medulloblastoma	2010
Dr Ed Schwalbe Dr Janet Lindsey Dr Meryl Lusher Kieran O'Toole Sarah Nicholson et al.	DNA methylomics identifies clinically significant epigenetic subgroups of medulloblastoma	2010
Sarah Nicholson Dr Nicholas Bown Professor Steven Clifford	Establishment of real-time centralised pathology review (CPR) and molecular diagnostics for medulloblastoma in the United Kingdom	2010
Dr James Hayden Dr Matthew Allen Dr Sarra Ryan Sarah Nicholson Dr Ed Schwalbe et al.	Molecular Mechanisms in Supratentorial CNS-PNET development	2010
Professor Steven Clifford Dr Sarra Ryan Mike Cole Dr Meryl Lusher Kieran O'Toole et al.	MYC gene family amplification and expression in childhood medulloblastoma: Biological significance and utility for high-risk disease stratification	2010
Dr Britta Vormoor Professor Nicola Curtin Professor Steven Clifford	Sensitisation of paediatric solid tumours to DNA-damaging chemotherapy by inhibition of DNA-dependent protein kinase (PRKDC)	2010
Professor Steven Clifford	Stratification of children and adolescents with medulloblastoma by histological and biological parameters in SIOP-Europe PNET clinical trials	2010
Dr Janet Lindsey Professor Steven Clifford Professor David Ellison Dr Richard Gilbertson	Subtypes of medulloblastoma have distinct developmental origins	2010
Dr Agata Rozanska Dr Evan Mulligan Huw Thomas Deborah Castelbuono Professor Deborah Tweddle et al.	[abstract] Central nervous system (CNS) penetration, poly-ADP ribose polymerase (PARP) inhibition and enhancement of temozolomide activity against childhood medulloblastoma by AG-014699	2009
Professor Steven Clifford Dr Nicholas Bown	A feasibility study of real-time biological characterisation of medulloblastoma in the United Kingdom	2009
Dr Sarra Ryan Professor David Elliott Professor David Ellison Professor Simon Bailey Professor Steven Clifford et al.	Amplification and overexpression of Hsa-miR-3ob, Hsa-miR-30d and KHDRBS3 at 8q24.22-q24.23 in medulloblastoma	2009
Professor Steven Clifford Kieran O'Toole Professor David Ellison	Chromosome 1q gain is not associated with a poor outcome in childhood medulloblastoma: requirements for the validation of potential prognostic biomarkers	2009
Dr James Hayden Professor David Ellison Professor Simon Bailey Professor Steven Clifford	Frequent IDH1 mutations in supratentorial primitive neuroectodermal tumors (sPNET) of adults but not children	2009
Professor Steven Clifford Professor David Ellison Kieran O'Toole	Improved Stratification of Standard Risk Medulloblastoma Patients by Clinical and Biological Prognostic Factors	2009
Dr Agata Rozanska Huw Thomas Dr Evan Mulligan Dr Yvette Drew Deborah Castelbuono et al.	Inhibition of Poly (ADP-Ribose) Polymerase-1 Enhances Temozolomide and Topotecan Activity against Childhood Neuroblastoma	2009
Dr Janet Lindsey Professor Steven Clifford	Methylation-Controlled J Protein	2009
Professor Steven Clifford Professor David Ellison	Novel mechanisms of gene disruption at the medulloblastoma isodicentric 17p11 breakpoint	2009
Professor Steven Clifford	The potential impact of tumour biology on improved clinical practice for medulloblastoma: progress towards biologically driven clinical trials	2009
Jennifer Anderton Dr Janet Lindsey Dr Meryl Lusher Dr Richard Gilbertson Professor Simon Bailey et al.	Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2	2008
Professor David Ellison Professor Steven Clifford	Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features	2008
Professor Steven Clifford	KidsCancerKinome: a EU-FP6 project for preclinical kinase inhibitor evaluation as a tool to prioritize compounds for paediatric development	2008
Professor Steven Clifford	Medulloblastoma: new insights into biology and treatment	2008
Professor Steven Clifford Dr Meryl Lusher Dr Janet Lindsey Dr Jackie Langdon Dr Richard Gilbertson et al.	Wnt-pathway medulloblastomas	2008
Professor David Ellison Dr Janet Lindsey Dr Meryl Lusher Professor Steven Clifford	Beta-catenin status predicts favorable prognosis in childhood medulloblastoma	2007
Professor Steven Clifford Yuan Lu Dr Debbie Scott Professor David Ellison	Chromosome 8 contains multiple independent loci involved in medulloblastoma development	2007
Dr Janet Lindsey Dr Meryl Lusher Jennifer Anderton Dr Richard Gilbertson Professor David Ellison et al.	Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma	2007
Professor Steven Clifford	Expression of drugable targets in pediatric malignancies: Innovative therapies for children with cancer	2007
Professor Steven Clifford Professor David Ellison	Identification of novel mechanisms for gene disruption at the medulloblastoma isochromosome breakpoint locus	2007
Charles McManamy Dr Jane Pears Professor Steven Clifford Professor David Ellison	Nodule formation and desmoplasia in medulloblastomas - Defining the nodular/desmoplastic variant and its biological behavior	2007
Professor Steven Clifford	Paediatric brain tumours: exploiting genomics to improve therapies	2007
Professor Steven Clifford Rachel Daniel Dr Agata Rozanska Huw Thomas Professor Alan Boddy et al.	Preclinical evaluation of the POLY-ADP ribose polymerase 1 (PARP-1) inhibitor AG014699 in combination with topotecan and temozolomide for the treatment of medulloblastoma and neuroblastoma	2007
Olabisi Onilude Dr Meryl Lusher Dr Janet Lindsey Professor Andrew Pearson Professor David Ellison et al.	APC and CTNNB1 mutations are rare in sporadic ependymomas	2006
Dr Jackie Langdon Dr Jayne Lamont Dr Debbie Scott Dr Nicholas Bown Professor David Ellison et al.	Combined genome-wide allelotyping and copy number analysis identify frequent genetic losses without copy number reduction in medulloblastoma	2006
Dr Janet Lindsey Dr Meryl Lusher Dr Gordon Strathdee Robert Brown Dr Richard Gilbertson et al.	Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours	2006
Dr Janet Lindsey Dr Meryl Lusher Dr Gordon Strathdee Dr Richard Gilbertson Professor Simon Bailey et al.	Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours	2006
Dr Poonam Dharmaraj Dr Stephen Ball Dr HC Johnstone Professor Simon Bailey Professor Steven Clifford et al.	Hypercalcaemia in relapsed medulloblastoma 8 years post-diagnosis; evidence to support PTHrP production by medulloblastoma cells	2006
Dr Debbie Scott Debbie Straughton Mike Cole Professor Simon Bailey Professor David Ellison et al.	Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma	2006
Dr Richard Gilbertson Dr Jackie Langdon Roberto Hernan Professor Steven Clifford	Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastoma	2006
Professor Steven Clifford Dr Meryl Lusher Dr Janet Lindsey Dr Jackie Langdon Dr Richard Gilbertson et al.	Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis	2006
Professor David Ellison Olabisi Onilude Dr Janet Lindsey Dr Meryl Lusher Professor Andrew Pearson et al.	β-catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee	2005
Dr Jayne Lamont Professor Deborah Tweddle Professor Andrew Pearson Professor Steven Clifford Professor David Ellison et al.	A 7-year-old boy with midline cerebellar mass	2005
Dr Janet Lindsey Jennifer Anderton Dr Meryl Lusher Professor Steven Clifford	Epigenetic events in medulloblastoma development	2005
David Hamilton Dr Meryl Lusher Dr Janet Lindsey Professor David Ellison Professor Steven Clifford et al.	Epigenetic inactivation of the RASSF1A tumour suppressor gene in ependymoma	2005
Dr Kevin Jones Professor Steven Clifford	Preclinical target analyisis in pediatric malignancies for selecting targeted compounds: Innovative therapies for children with cancer.	2005
Dr Christopher Calabrese Professor Steven Clifford Dr Richard Gilbertson	The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation	2005
Dr Christopher Calabrese Professor Steven Clifford Dr Richard Gilbertson	The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation	2005
Professor David Ellison Professor Andrew Pearson Professor Steven Clifford Dr Jayne Lamont Charles McManamy et al.	Combined histopathological and molecular cytogenetic stratification defines a high-risk subset of patients with medulloblastoma - A United Kingdom Children's Cancer Group Study	2004
Dr Jayne Lamont Charles McManamy Professor Andrew Pearson Professor Steven Clifford Professor David Ellison et al.	Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients	2004
Professor Steven Clifford Dr Janet Lindsey Dr Meryl Lusher Dr Richard Gilbertson Professor Andrew Pearson et al.	Identification of tumour suppressor genes in childhood medulloblastoma by promoter hypermethylation profiling	2004
Dr Janet Lindsey Dr Meryl Lusher Jennifer Anderton Professor Simon Bailey Dr Richard Gilbertson et al.	Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling	2004
Professor David Ellison Charles McManamy Professor Andrew Pearson Professor Steven Clifford	The clinical utility of stratifying medulloblastomas (MBs) by a combination of detailed histopathologic evaluation and molecular cytogenetic analysis	2004
Professor Steven Clifford	The molecular genetics and pathology of renal cell carcinoma	2004
Dr Adrian Frank Roberto Hernan Dr Janet Lindsey Dr Meryl Lusher Professor Steven Clifford et al.	The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma	2004
James Cooke Professor Steven Clifford	Identification of pVHL-interacting proteins and their role in pheochromocytoma development	2003
Dr Janet Lindsey Dr Meryl Lusher Professor Andrew Pearson Professor David Ellison Professor Steven Clifford et al.	Identification of tumour suppressor genes in childhood medulloblastoma by promoter hypermethylation profiling	2003
Dr Debbie Scott Dr Janet Lindsey Dr Meryl Lusher Professor Andrew Pearson Professor David Ellison et al.	Identification of tumour suppressor loci on chromosome 10q in medulloblastoma	2003
Dr Jackie Langdon Roberto Hernan Dr Richard Gilbertson Professor Steven Clifford	Molecular analysis of the PDGFR alpha-RAS/MAPK pathway in childhood medulloblastoma	2003
Dr Jayne Lamont Charles McManamy Professor Andrew Pearson Professor Steven Clifford Professor David Ellison et al.	Molecular cytogenetic analysis of a cohort of medulloblastomas	2003
Charles McManamy Dr Jayne Lamont Mike Cole Professor Andrew Pearson Professor Steven Clifford et al.	Morphophenotypic variation predicts clinical behavior in childhood non-desmoplastic medulloblastomas	2003
Dr Richard Gilbertson Professor Steven Clifford	PDGFRB is overexpressed in metastatic medulloblastoma	2003
Professor David Ellison Professor Steven Clifford Dr Richard Gilbertson	What's new in neuro-oncology? Recent advances in medulloblastoma	2003
Dr Meryl Lusher Dr Janet Lindsey Professor Andrew Pearson Professor David Ellison Professor Steven Clifford et al.	Biallelic epigenetic inactivation of the RASSF1A tumor suppressor gene in medulloblastoma development	2002
Professor Steven Clifford	Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease	2002
Professor Steven Clifford	Mucilages and polysaccharides in Ziziphus species (Rhamnaceae): localization, composition and physiological roles during drought-stress	2002
Professor Steven Clifford	Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas	2001
Professor Steven Clifford	Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas	2001
Professor Steven Clifford	Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease	2001
Professor Steven Clifford	Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease	2001
Professor Steven Clifford	The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma	2001
Professor Steven Clifford	The pVHL-associated SCF ubiquitin ligase complex: Molecular genetic analysis of elongin B and C, Rbx1 and HIF-1α in renal cell carcinoma	2001
Professor Steven Clifford	Von Hippel-Lindau disease: clinical and molecular perspectives	2001
Professor Steven Clifford	Comparative sequence analysis of the VHL tumor suppressor gene	2000
Professor Steven Clifford	Familial clear cell renal cell carcinoma (FCRC): clinical features and mutation analysis of the VHL, MET, and CUL2 candidate genes	2000
Professor Steven Clifford	Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein	2000
Professor Steven Clifford	Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein	2000
Professor Steven Clifford	Differences in allelic distribution of two polymorphisms in the VHL-associated gene CUL2 in pheochromocytoma patients without somatic CUL2 mutations	1999
Professor Steven Clifford	Genomic organization and chromosomal localization of the human CUL2 gene and the role of von Hippel-Lindau tumor suppressor-binding protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma development	1999
Professor Steven Clifford	Genomic organization and chromosomal localization of the human CUL2 gene and the role of von Hippel-Lindau tumor suppressor-binding protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma development	1999
Professor Steven Clifford	The molecular genetics of renal cell carcinoma	1999
Professor Steven Clifford	The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis	1999
Dr Richard Gilbertson Professor Steven Clifford Dr Christopher Wright Emeritus Professor Robert Perry Professor Andrew Pearson et al.	Expression of the ErbB-neuregulin signaling network during human cerebellar development: Implications for the biology of medulloblastoma	1998
Professor Steven Clifford	Hepatocyte growth factor-stimulated renal tubular mitogenesis: effects on expression of c-myc, c-fos, c-met, VEGF and the VHL tumour-suppressor and related genes	1998
Professor Steven Clifford	Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: evidence for a VHL-independent pathway in clear cell renal tumourigenesis	1998
Professor Steven Clifford Professor David Neal Professor John Lunec	Alterations in expression of the multidrug resistance-associated protein (MRP) gene in high-grade transitional cell carcinoma of the bladder	1996
Professor Steven Clifford Professor David Neal Professor John Lunec	High level expression of the multidrug resistance (MDR1) gene in the normal bladder urothelium: A potential involvement in protection against carcinogens?	1996
Professor Steven Clifford David Thomas Professor David Neal Professor John Lunec	Increased MDR1 gene transcript levels in high-grade carcinoma of the bladder determined by quantitative PCR-based assay	1994