Publications by Dr Heather Lamb - ePrints

Browsing publications by Dr Heather Lamb.

Newcastle Authors	Title	Year
Dr Arnaud Basle Dr Lorraine Hewitt Dr Alan Koh Dr Heather Lamb Paul Thompson et al.	Crystal structure of NucB, a biofilm-degrading endonuclease	2018
Dr David Wilkinson Angie Habgood Dr Heather Lamb Paul Thompson Professor Alastair Hawkins et al.	Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms	2017
Dr Heather Lamb Professor Alastair Hawkins	Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases	2014
Dr Heather Lamb Paul Thompson Professor Alastair Hawkins	Crystal structure of the dimer of two essential Salmonella typhimurium proteins, YgjD and YeaZ and calorimetric evidence for the formation of a ternary YgjD-YeaZ-YjeE complex	2013
Shaun Martin Dr Heather Lamb Paul Thompson Professor Penny Lovat Professor Alastair Hawkins et al.	Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78	2013
Dr Heather Lamb Professor Alastair Hawkins	Mechanistic Basis of the Inhibition of Type II Dehydroquinase by (2S)- and (2R)-2-Benzyl-3-dehydroquinic Acids	2013
Dr Heather Lamb Professor Alastair Hawkins	Interaction between relaxase MbeA and accessory protein MbeC of the conjugally mobilizable plasmid ColE1	2012
Dr Heather Lamb Professor Alastair Hawkins	A Prodrug Approach for Improving Antituberculosis Activity of Potent Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors	2011
Dr Heather Lamb Professor Alastair Hawkins	Crystallographic and microcalorimetric analyses reveal the structural basis for high arginine specificity in the Salmonella enterica serovar Typhimurium periplasmic binding protein STM4351	2011
Dr Heather Lamb Professor Alastair Hawkins	Tetrahydrobenzothiophene Derivatives: Conformationally Restricted Inhibitors of Type II Dehydroquinase	2011
Dr Heather Lamb Professor Alastair Hawkins	Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: An unusual Type II glyoxalase	2010
Elaine Zhao Samantha Hume Dr Christopher Johnson Paul Thompson Dr Jun-yong Huang et al.	The transcription repressor NmrA is subject to proteolysis by three Aspergillus nidulans proteases	2010
Dr Heather Lamb Professor Alastair Hawkins	Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids	2010
Dr Heather Lamb Professor Alastair Hawkins	2-Substituted-3-Dehydroquinic Acids as Potent Competitive Inhibitors of Type II Dehydroquinase	2009
Dr Heather Lamb Professor Alastair Hawkins	Competitive inhibitors of Helicobacter pylori type II dehydroquinase: Synthesis, biological evaluation, and NMR studies	2008
Dr Heather Lamb Professor Alastair Hawkins	Dinucleotide-sensing proteins: linking signaling networks and regulating transcription	2008
Dr Heather Lamb Professor Alastair Hawkins	MbeA and MbeC, proteins key to ColE1 plasmid mobilisation, interact in vitro with a 1 : 1 stoichiometry	2008
Dr Heather Lamb Professor Alastair Hawkins	Structural Analysis of the Recognition of the Negative Regulator NmrA and DNA by the Zinc Finger from the GATA-Type Transcription Factor AreA	2008
Dr Heather Lamb Professor Alastair Hawkins	Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases	2007
Dr Heather Lamb Paul Thompson Dr Nick Watkins Professor Alastair Hawkins	Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium	2007
Dr Heather Lamb Professor Alastair Hawkins	Nanomolar competitive inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor type II dehydroquinase	2007
Dr Heather Lamb Professor Alastair Hawkins	Structure of the ribosomal interacting GTPase YjeQ from the enterobacterial species Salmonella typhimurium	2007
Dr Heather Lamb Professor Alastair Hawkins	Determination of the bound conformation of a competitive nanomolar inhibitor of Mycobacterium tuberculosis type II dehydroquinase by NMR spectroscopy	2006
Dr David Allen Chalton Dr Heather Lamb Professor John Robinson Professor Jeremy Lakey	Immunogenicity of a Yersinia pestis vaccine antigen monomerized by circular permutation	2006
Dr Christopher Johnson Dr Heather Lamb Professor Alastair Hawkins	Structural characterization of Salmonella typhimurium YeaZ, an M22 O-sialoglycoprotein endopeptidase homolog	2006
Dr Heather Lamb Christopher Mee Professor Alastair Hawkins	The affinity of a major Ca2+ binding site on GRP78 is differentially enhanced by ADP and ATP	2006
Dr Heather Lamb Professor Alastair Hawkins	GTP cyclohydrolase II structure and mechanism	2005
Dr Alison Park Dr Heather Lamb Professor Alastair Hawkins	Biophysical and kinetic analysis of wild-type and site-directed mutants of the isolated and native dehydroquinate synthase domain of the AROM protein	2004
Dr Heather Lamb Dr Alison Park Dr Christopher Johnson Dr Simon Cocklin Paul Thompson et al.	Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis	2004
Dr Heather Lamb Professor Alastair Hawkins	Ligand-induced conformational changes and a mechanism for domain closure in Aspergillus nidulans dehydroquinate synthase	2003
Dr Heather Lamb Dr Anna Dodds Dr Christopher Johnson Professor Alastair Hawkins	The negative transcriptional regulator NmrA discriminates between oxidized and reduced dinucleotides	2003
Professor Alastair Hawkins Dr Heather Lamb	A thermodynamic study of the reactions: {2-dehydro-3-deoxy-D-arabino-heptanoate 7-phosphate(aq) = 3-dehydroquinate(aq) + phosphate(aq)} and {3-dehydroquinate(aq) = 3-dehydroshikimate(aq) + H2O(1)}	2002
Dr Heather Lamb	Demonstration of Hot Start characteristics in Transgenomic Optimase (TM) polymerase	2002
Dr Carys Watts Dr Heather Lamb Professor Alastair Hawkins	Kinetic analysis of the interaction between the QutA and QutR transcription-regulating proteins	2002
Dr Alison Spiers Dr Heather Lamb Dr Simon Cocklin Dr Anna Dodds Professor Alastair Hawkins et al.	PDZ domains facilitate binding of high temperature requirement protease A (HtrA) and tail-specific protease (Tsp) to heterologous substrates through recognition of the small stable RNA A (ssrA)-encoded peptide	2002
Dr Heather Lamb	Predicting the optimal PCR primer annealing temperature for use with the Transgenomic Optimase (TM) polymerase.	2002
Dr Simon Cocklin Dr Anna Dodds Dr Heather Lamb Professor Alastair Hawkins	Expression, purification and crystallization of Aspergillus nidulans NmrA, a negative regulatory protein involved in nitrogen-metabolite repression	2001
Dr Heather Lamb Faye Haldane Professor Alastair Hawkins	Identification of many crystal forms of Aspergillus nidulans dehydroquinate synthase	2001
Dr Heather Lamb Dr Simon Cocklin Dr Anna Dodds Professor Alastair Hawkins	The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases	2001
Dianne Smith Dr Heather Lamb Professor Alastair Hawkins	Identification of domains responsible for signal recognition and transduction within the QUTR transcription repressor protein	2000
Dr Heather Lamb Alan Leake Professor Ian McKeith Emeritus Professor Robert Perry Dr Christopher Morris et al.	No association between a polymorphism in the presenilin 1 gene and dementia with Lewy bodies	1997
Dr Heather Lamb Alan Leake Professor Ian McKeith Emeritus Professor Robert Perry Dr Christopher Morris et al.	No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer's disease	1997
Dr Christopher Morris Alan Leake Dr Michael Griffiths Dr Heather Lamb Andrew Brown et al.	Molecular biology of APO E alleles in Alzheimer's and non-Alzheimer's dementias	1996