Dr Arnaud Basle Dr Lorraine Hewitt Dr Alan Koh Dr Heather Lamb Paul Thompson et al. | Crystal structure of NucB, a biofilm-degrading endonuclease | 2018 |
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Dr David Wilkinson Angie Habgood Dr Heather Lamb Paul Thompson Professor Alastair Hawkins et al. | Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms | 2017 |
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Dr Heather Lamb Professor Alastair Hawkins
| Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases | 2014 |
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Dr Heather Lamb Paul Thompson Professor Alastair Hawkins
| Crystal structure of the dimer of two essential Salmonella typhimurium proteins, YgjD and YeaZ and calorimetric evidence for the formation of a ternary YgjD-YeaZ-YjeE complex | 2013 |
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Shaun Martin Dr Heather Lamb Paul Thompson Professor Penny Lovat Professor Alastair Hawkins et al. | Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78 | 2013 |
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Dr Heather Lamb Professor Alastair Hawkins
| Mechanistic Basis of the Inhibition of Type II Dehydroquinase by (2S)- and (2R)-2-Benzyl-3-dehydroquinic Acids | 2013 |
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Dr Heather Lamb Professor Alastair Hawkins
| Interaction between relaxase MbeA and accessory protein MbeC of the conjugally mobilizable plasmid ColE1 | 2012 |
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Dr Heather Lamb Professor Alastair Hawkins
| A Prodrug Approach for Improving Antituberculosis Activity of Potent Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors | 2011 |
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Dr Heather Lamb Professor Alastair Hawkins
| Crystallographic and microcalorimetric analyses reveal the structural basis for high arginine specificity in the Salmonella enterica serovar Typhimurium periplasmic binding protein STM4351 | 2011 |
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Dr Heather Lamb Professor Alastair Hawkins
| Tetrahydrobenzothiophene Derivatives: Conformationally Restricted Inhibitors of Type II Dehydroquinase | 2011 |
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Dr Heather Lamb Professor Alastair Hawkins
| Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: An unusual Type II glyoxalase | 2010 |
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Elaine Zhao Samantha Hume Dr Christopher Johnson Paul Thompson Dr Jun-yong Huang et al. | The transcription repressor NmrA is subject to proteolysis by three Aspergillus nidulans proteases | 2010 |
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Dr Heather Lamb Professor Alastair Hawkins
| Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids | 2010 |
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Dr Heather Lamb Professor Alastair Hawkins
| 2-Substituted-3-Dehydroquinic Acids as Potent Competitive Inhibitors of Type II Dehydroquinase | 2009 |
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Dr Heather Lamb Professor Alastair Hawkins
| Competitive inhibitors of Helicobacter pylori type II dehydroquinase: Synthesis, biological evaluation, and NMR studies | 2008 |
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Dr Heather Lamb Professor Alastair Hawkins
| Dinucleotide-sensing proteins: linking signaling networks and regulating transcription | 2008 |
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Dr Heather Lamb Professor Alastair Hawkins
| MbeA and MbeC, proteins key to ColE1 plasmid mobilisation, interact in vitro with a 1 : 1 stoichiometry | 2008 |
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Dr Heather Lamb Professor Alastair Hawkins
| Structural Analysis of the Recognition of the Negative Regulator NmrA and DNA by the Zinc Finger from the GATA-Type Transcription Factor AreA | 2008 |
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Dr Heather Lamb Professor Alastair Hawkins
| Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases | 2007 |
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Dr Heather Lamb Paul Thompson Dr Nick Watkins Professor Alastair Hawkins
| Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium | 2007 |
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Dr Heather Lamb Professor Alastair Hawkins
| Nanomolar competitive inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor type II dehydroquinase | 2007 |
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Dr Heather Lamb Professor Alastair Hawkins
| Structure of the ribosomal interacting GTPase YjeQ from the enterobacterial species Salmonella typhimurium | 2007 |
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Dr Heather Lamb Professor Alastair Hawkins
| Determination of the bound conformation of a competitive nanomolar inhibitor of Mycobacterium tuberculosis type II dehydroquinase by NMR spectroscopy | 2006 |
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Dr David Allen Chalton Dr Heather Lamb Professor John Robinson Professor Jeremy Lakey
| Immunogenicity of a Yersinia pestis vaccine antigen monomerized by circular permutation | 2006 |
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Dr Christopher Johnson Dr Heather Lamb Professor Alastair Hawkins
| Structural characterization of Salmonella typhimurium YeaZ, an M22 O-sialoglycoprotein endopeptidase homolog | 2006 |
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Dr Heather Lamb Christopher Mee Professor Alastair Hawkins
| The affinity of a major Ca2+ binding site on GRP78 is differentially enhanced by ADP and ATP | 2006 |
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Dr Heather Lamb Professor Alastair Hawkins
| GTP cyclohydrolase II structure and mechanism | 2005 |
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Dr Alison Park Dr Heather Lamb Professor Alastair Hawkins
| Biophysical and kinetic analysis of wild-type and site-directed mutants of the isolated and native dehydroquinate synthase domain of the AROM protein | 2004 |
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Dr Heather Lamb Dr Alison Park Dr Christopher Johnson Dr Simon Cocklin Paul Thompson et al. | Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis | 2004 |
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Dr Heather Lamb Professor Alastair Hawkins
| Ligand-induced conformational changes and a mechanism for domain closure in Aspergillus nidulans dehydroquinate synthase | 2003 |
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Dr Heather Lamb Dr Anna Dodds Dr Christopher Johnson Professor Alastair Hawkins
| The negative transcriptional regulator NmrA discriminates between oxidized and reduced dinucleotides | 2003 |
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Professor Alastair Hawkins Dr Heather Lamb
| A thermodynamic study of the reactions: {2-dehydro-3-deoxy-D-arabino-heptanoate 7-phosphate(aq) = 3-dehydroquinate(aq) + phosphate(aq)} and {3-dehydroquinate(aq) = 3-dehydroshikimate(aq) + H2O(1)} | 2002 |
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Dr Heather Lamb
| Demonstration of Hot Start characteristics in Transgenomic Optimase (TM) polymerase | 2002 |
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Dr Carys Watts Dr Heather Lamb Professor Alastair Hawkins
| Kinetic analysis of the interaction between the QutA and QutR transcription-regulating proteins | 2002 |
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Dr Alison Spiers Dr Heather Lamb Dr Simon Cocklin Dr Anna Dodds Professor Alastair Hawkins et al. | PDZ domains facilitate binding of high temperature requirement protease A (HtrA) and tail-specific protease (Tsp) to heterologous substrates through recognition of the small stable RNA A (ssrA)-encoded peptide | 2002 |
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Dr Heather Lamb
| Predicting the optimal PCR primer annealing temperature for use with the Transgenomic Optimase (TM) polymerase. | 2002 |
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Dr Simon Cocklin Dr Anna Dodds Dr Heather Lamb Professor Alastair Hawkins
| Expression, purification and crystallization of Aspergillus nidulans NmrA, a negative regulatory protein involved in nitrogen-metabolite repression | 2001 |
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Dr Heather Lamb Faye Haldane Professor Alastair Hawkins
| Identification of many crystal forms of Aspergillus nidulans dehydroquinate synthase | 2001 |
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Dr Heather Lamb Dr Simon Cocklin Dr Anna Dodds Professor Alastair Hawkins
| The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases | 2001 |
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Dianne Smith Dr Heather Lamb Professor Alastair Hawkins
| Identification of domains responsible for signal recognition and transduction within the QUTR transcription repressor protein | 2000 |
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Dr Heather Lamb Alan Leake Professor Ian McKeith Emeritus Professor Robert Perry Dr Christopher Morris et al. | No association between a polymorphism in the presenilin 1 gene and dementia with Lewy bodies | 1997 |
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Dr Heather Lamb Alan Leake Professor Ian McKeith Emeritus Professor Robert Perry Dr Christopher Morris et al. | No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer's disease | 1997 |
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Dr Christopher Morris Alan Leake Dr Michael Griffiths Dr Heather Lamb Andrew Brown et al. | Molecular biology of APO E alleles in Alzheimer's and non-Alzheimer's dementias | 1996 |
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