Publications by Dr Lee Borthwick - ePrints

Browsing publications by Dr Lee Borthwick.

Newcastle Authors	Title	Year
Dr Lee Borthwick	Defining the mechanism of galectin-3–mediated TGF-β1 activation and its role in lung fibrosis	2024
Lucy Gee Dr Ben Barron-Millar Dr Marco Zaki Dr Saimir Luli Rachel Burgoyne et al.	Anti–Cholestatic Therapy with Obeticholic Acid Improves Short-Term Memory in Bile Duct–Ligated Mice	2023
Professor Andrew Fisher Dr Lee Borthwick	Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation	2023
Laura Sabater Jean-Baptiste Gossart Inmaculada Hernandez Lopez Dr Daniel Rico Rodriguez Dr Lee Borthwick et al.	miRNA Expression in Fibroblastic Foci within Idiopathic Pulmonary Fibrosis Lungs Reveals Novel Disease-Relevant Pathways	2023
Tom Pither Dr Lu Wang Lucy Bates Dr Morvern Morrison Catriona Charlton et al.	Modeling the Effects of IL-1β-mediated Inflammation During Ex Vivo Lung Perfusion Using a Split Human Donor Model	2023
Dr Lee Borthwick Professor Andrew Fisher	Altered Differentiation and Inflammation Profiles Contribute to Enhanced Innate Responses in Severe COPD Epithelium to Rhinovirus Infection	2022
Dr Marco Zaki Dr Sari Alhasan Dr Ruchi Shukla Misti McCain Maja Laszczewska et al.	Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma?	2022
Dr Morvern Morrison Dr Anders Andreasson Catriona Charlton Dr Alisha Chhatwal Dr Bill Scott et al.	Transcriptional analysis identifies potential novel biomarkers associated with successful ex-vivo perfusion of human donor lungs	2022
Dr Jack Leslie Dr Hannah Paish Amy Collins Rebecca Scott Abi Watson et al.	A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis	2021
JinHeng Lin Professor Michael Taggart Dr Lee Borthwick Professor Andrew Fisher Dr Malcolm Brodlie et al.	Acute cigarette smoke or extract exposure rapidly activates TRPA1-mediated calcium influx in primary human airway smooth muscle cells	2021
Dr Lee Borthwick Ben Barksby Rachel Burgoyne Rory Barnes Professor Andrew Fisher et al.	Pharmacological characterisation of GSK3335103, an oral αvβ6 integrin small molecule RGD-mimetic inhibitor for the treatment of fibrotic disease	2021
Rachel Burgoyne Professor Andrew Fisher Dr Lee Borthwick	The role of epithelial damage in the pulmonary immune response	2021
Dr Julie Worrell Dr Jack Leslie Dr Graham Smith Marco Zaki Dr Hannah Paish et al.	cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis	2020
Dr Jack Leslie Dr Marina Garcia Macia Dr Saimir Luli Dr Julie Worrell William Reilly et al.	c-Rel orchestrates energy-dependant epithelial and macrophage reprogramming in fibrosis	2020
Dr Jack Leslie Benjamin Millar Alicia Del Carpio Pons Rachel Burgoyne Joseph Frost et al.	FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis	2020
Ben Barksby Dr Lee Borthwick	Pellino-1 Regulates the Responses of the Airway to Viral Infection	2020
Professor Derek Mann Dr Lee Borthwick Professor David Deehan Dr Nicholas Kalson	Quantification of intra-articular fibrosis in patients with stiff knee arthroplasties using metal-reduction MRI	2020
Dr Alistair Leitch Dr Tarek Mamdouh Abdelghany Dr Alex Charlton Professor Fiona Oakley Dr Lee Borthwick et al.	Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse	2020
Dr Lee Borthwick Professor Andrew Fisher	The circadian clock protein REVERBα inhibits pulmonary fibrosis development	2020
Dr Lee Borthwick Ben Barksby Rachel Burgoyne Rory Barnes Professor Andrew Fisher et al.	Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis	2020
Dr Hannah Paish Lee Reed Helen Brown Mark Bryan Dr Olivier Govaere et al.	A bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices	2019
Dr Hannah Paish Dr Colin Gillespie Alicia Del Carpio Pons Professor Derek Mann Professor David Deehan et al.	Chronic, Active Inflammation in Patients with Failed Total Knee Replacements Undergoing Revision Surgery	2019
Professor Fiona Oakley Lucy Gee Professor Neil Sheerin Dr Lee Borthwick	Implementation of pre-clinical methodologies to study fibrosis and test anti-fibrotic therapy	2019
Dr Hannah Paish Dr Nicholas Kalson Dr Graham Smith Alicia Del Carpio Pons Nicholas Smith et al.	Fibroblasts Promote Inflammation and Pain via IL-1α Induction of the Monocyte Chemoattractant Chemokine (C-C Motif) Ligand 2	2018
Dr Nicholas Kalson Timothy Brock Professor Derek Mann Dr Lee Borthwick Professor David Deehan et al.	Reduced telomere length is associated with fibrotic joint disease suggesting that impaired telomere repair contributes to joint fibrosis	2018
Dr Sonya Carnell Dr John Perry Dr Lee Borthwick Dr Daniela Vollmer Dr Jacob Biboy et al.	Targeting the bacterial cytoskeleton of the Burkholderia cepacia complex for antimicrobial development: A cautionary tale	2018
Dr Caroline Wilson Professor Derek Mann Dr Lee Borthwick	Epigenetic reprogramming in liver fibrosis and cancer	2017
Anders Andreasson Danai Karamanou Dr Colin Gillespie Kasim Jiwa Dr Nicola Green et al.	Profiling inflammation and tissue injury markers in perfusate and bronchoalveolar lavage fluid during human ex vivo lung perfusion	2017
Anders Andreasson Dr Lee Borthwick Dr Colin Gillespie Kasim Jiwa Jonathan Scott et al.	The role of interleukin-1β as a predictive biomarker and potential therapeutic target during clinical ex vivo lung perfusion	2017
Dr Lee Borthwick	Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-β	2017
Dr Lee Borthwick Wona Suwara Dr Sonya Carnell Dr Nicola Green Dr Rahul Mahida et al.	Pseudomonas aeruginosa induced Airway Epithelial Injury Drives Fibroblast Activation: A Mechanism in Chronic Lung Allograft Dysfunction	2016
Dr Lee Borthwick	Acidic chitinase primes the protective immune response to gastrointestinal nematodes	2016
Dr Lee Borthwick	Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine-driven inflammation and fibrosis	2016
Dr Nicholas Kalson Dr Lee Borthwick Professor Derek Mann Professor David Deehan	International consensus on the definition and classification of fibrosis of the knee joint	2016
Dr Lee Borthwick Professor Andrew Fisher	Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis	2016
Dr Lee Borthwick Professor Derek Mann	Osteopontin and HMGB1: novel regulators of HSC activation	2016
Kasim Jiwa Dr Lee Borthwick Dr Anders Andreasson Professor John Dark Professor Andrew Fisher et al.	Potential therapeutic benefits of the human amniotic epithelium cell secretome during ex-vivo perfusion of donor lungs	2016
Dr Lee Borthwick Professor Andrew Fisher Professor Christopher Buckley	Role of CD248 as a potential severity marker in idiopathic pulmonary fibrosis	2016
Dr Lee Borthwick	Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A	2016
Dr Lee Borthwick	The IL-1 cytokine family and its role in inflammation and fibrosis in the lung	2016
Dr Anders Andreasson Danai Karamanou Dr Colin Gillespie Dr Lee Borthwick Kasim Jiwa et al.	Treating Donor Lung Inflammation by Blocking Interleukin-1B-An In Vitro Therapy Testing Platform for Ex Vivo Lung Perfusion	2016
David Dixon Jonathon Coates Joanna Horabin Andrew Walker Dr Nicole Abdul et al.	A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty	2015
Dr Nicole Abdul David Dixon Andrew Walker Joanna Horabin Professor David Deehan et al.	Fibrosis is a common outcome following total knee arthroplasty	2015
Dr Stephen Ball Monika Suwara Dr Lee Borthwick Emerita Professor Janet Wilson Professor Derek Mann et al.	How Reliable are Sino-Nasal Cell Lines for Studying the Pathophysiology of Chronic Rhinosinusitis?	2015
Dr Lee Borthwick	T_H2 and T_H17 inflammatory pathways are reciprocally regulated in asthma	2015
Wona Suwara Dr Nicola Green Dr Lee Borthwick Professor Jelena Mann Professor Andrew Fisher et al.	IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts	2014
Dr Lee Borthwick	Incomplete Deletion of IL-4R alpha by LysM^Cre Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis	2014
Monika Suwara Dr Bart Vanaudenaerde Dr Nicola Green Professor Christopher Ward Dr Lee Borthwick et al.	Mechanistic differences between phenotypes of chronic lung allograft dysfunction after lung transplantation	2014
Dr Lee Borthwick Professor Andrew Fisher	TNF- α/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction	2014
Dr Lee Borthwick Professor Andrew Fisher	Cytokine mediated tissue fibrosis	2013
Dr Lindsay Murphy Dr Saimir Luli Dr Lee Borthwick Dr Steven O'Reilly Professor Neil Perkins et al.	Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response	2013
Dr Lee Borthwick	Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation	2013
Dr Lee Borthwick Dr Rahul Mahida Andrew Walker Aaron Gardner Wona Suwara et al.	TNFα From Classically Activated Macrophages Accentuates Epithelial to Mesenchymal Transition in Obliterative Bronchiolitis	2013
Marta Gorowiec Dr Lee Borthwick Dr Sean Parker Emeritus Professor John Kirby Dr Gabriele Saretzki et al.	Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-beta 1-dependent mechanism	2012
Wona Suwara Dr Lee Borthwick Dr Rahul Mahida Dr Nicola Green Aaron Gardner et al.	Interleukin-1 Alpha (IL-1α) Released from Injured Lung Epithelium is a Critical Alarmin Driving Activation of a Potent Inflammatory Phenotype in Lung Fibroblasts	2012
Dr Nicola Green Wona Suwara Dr Lee Borthwick Professor Derek Mann Professor Andrew Fisher et al.	Interleukin-33 in Chronic Lung Disease	2012
Dr Aaron Ions Gardner Professor Andrew Fisher Christine Richter Grace Johnson Dr Elizabeth Moisey et al.	The Critical Role of TAK1 in Accentuated Epithelial to Mesenchymal Transition in Obliterative Bronchiolitis after Lung Transplantation	2012
Dr Lee Borthwick Aaron Gardner Professor Anthony De Soyza Professor Derek Mann Professor Andrew Fisher et al.	Transforming Growth Factor-β1 (TGF-β1) Driven Epithelial to Mesenchymal Transition (EMT) is Accentuated by Tumour Necrosis Factor α (TNFα) via Crosstalk Between the SMAD and NF-κB Pathways	2012
Dr Lee Borthwick Dr Aaron Ions Gardner Professor Anthony De Soyza Professor Derek Mann Professor Andrew Fisher et al.	Transforming Growth Factor-β1 (TGF-β1) Driven Epithelial to Mesenchymal Transition (EMT) is Accentuated by Tumour Necrosis Factor α (TNFα) via Crosstalk Between the SMAD and NF-κB Pathways	2012
Dr Lee Borthwick Dr John Perry Dr Malcolm Brodlie Professor Christopher Ward Katherine Gould et al.	Pseudomonas aeruginosa accentuates epithelial-to-mesenchymal transition in the airway	2011
Dr Rahul Mahida Monika Suwara Dr Gavin Johnson Professor Derek Mann Dr Lee Borthwick et al.	Alarmins in bronchiolitis obliterans syndrome after lung transplantation	2011
Dr Lee Borthwick Phil Botha Dr Malcolm Brodlie Aaron Gardner Dr David Bourn et al.	Is CFTR-delF508 Really Absent from the Apical Membrane of the Airway Epithelium?	2011
Monika Suwara Dr Rahul Mahida Dr Lee Borthwick Professor Jelena Mann Professor Derek Mann et al.	The Epithelial Alarmin, Interleukin 1 alpha (IL-1 alpha), Is a Potential Fibrogenic Factor in Bronchiolitis Obliterans Syndrome (BOS)	2011
Dr Elizabeth Moisey Dr Lee Borthwick Dr John Perry Professor Anthony De Soyza Professor Andrew Fisher et al.	Cigarette smoke dysregulates pro-inflammatory cytokine release from airway epithelial cells and macrophages in response to haemophilus influenzae	2010
Monika Suwara Dr Lee Borthwick Professor Jelena Mann Professor Andrew Fisher Professor Derek Mann et al.	IL-1 IS A KEY EPITHELIAL ALARMIN WHICH PROMOTES FIBROBLAST ACTIVATION	2010
Dr Lee Borthwick Marta Gorowiec Dr Malcolm Brodlie Professor Christopher Ward Dr James Lordan et al.	Inflammation and Epithelial to Mesenchymal Transition in Lung Transplant Recipients: Role in Dysregulated Epithelial Wound Repair	2010
Aaron Gardner Dr Lee Borthwick Professor Andrew Fisher	Lung epithelial wound healing in health and disease	2010
Dr Laura Mackay Dr Hannah Walden Aaron Gardner Dr Lee Borthwick Professor Andrew Fisher et al.	Microvascular endothelial cell apoptosis and dysregulation of vascular endothelial growth factor receptor 2 (VEGF-R2) in response to cigarette smoke. New insights into the pathogenesis of emphysema	2010
Dr Lee Borthwick Dr Malcolm Brodlie Professor Christopher Ward Dr John Perry Professor Anthony De Soyza et al.	The M1 macrophage phenotype accentuates TGF-beta 1 driven epithelial to mesenchymal transition (EMT) via the secretion of TNF alpha	2010
Dr Aaron Ions Gardner Dr Malcolm Brodlie Professor Derek Mann Dr Lee Borthwick Professor Andrew Fisher et al.	The role of transforming growth factor-beta activated kinase-1 (TAK-1) in the development of airway fibrosis	2010
Dr Lee Borthwick Dr Sean Parker Kate Brougham Marta Gorowiec Professor Christopher Ward et al.	Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation	2009
Dr Lee Borthwick Clare Pate Dr Joaquim Majo Professor Andrew Fisher	Morphometric comparison of airway remodelling in chronic obstructive pulmonary disease and obliterative bronchiolitis	2009
Dr Lee Borthwick Dr Malcolm Brodlie Professor Christopher Ward Dr James Lordan Emeritus Professor John Kirby et al.	Pro-inflammatory Cytokines IL-1 beta and TNT alpha, but Not IL-8, Cause Aberrant Lung Epithelial Wound Repair Via TGF-beta 1 Driven Epithelial to Mesenchymal Transition (EMT)	2009
Dr Lee Borthwick Dr John Perry Professor Andrew Fisher Professor Anthony De Soyza	Proinflammatory potential of pseudomonas aeruginosa in macrophage models: Importance of clinical origin?	2009
Dr Sean Parker Dr Lee Borthwick Professor Christopher Ward Dr James Lordan Dr Gabriele Saretzki et al.	Airway epithelial cell senescence in the lung allograft	2008
Marta Gorowiec Dr Lee Borthwick Marcin Pekalski Dr James Lordan Professor Christopher Ward et al.	Oxidative stress induces epithelial to mesenchymal transition in human lung epithelial cells through transforming groeth factor beta and integrin beta6-dependent mechanism	2008
Dr Lee Borthwick Kate Brougham Professor Christopher Ward Dr James Lordan Emeritus Professor John Kirby et al.	Pro-inflammatory cytokines dysregulate lung epithelial wound repair via epithelial to mesenchymal transition	2008
Dr Lee Borthwick Sally Maloney Dr Rachel Anderson Professor Christopher Ward Dr James Lordan et al.	Transforming growth factor beta 1 suppresses secretory leucoprotease inhibitor release in response to infection in lung epithelial cells	2008
Dr Lee Borthwick Dr Sean Parker Marta Gorowiec Professor Christopher Ward Dr James Lordan et al.	Tumour necrosis factor-α accentuates transforming growth factor-β driven epithelial to mesenchymal transition (EMT) in airway epithelial cells from lung transplant recipients	2008
Marta Gorowiec Dr Sean Parker Dr Lee Borthwick Professor Christopher Ward Dr James Lordan et al.	Oxidative stress increases transforming growth factor-beta expression and drives epithelial to mesenchymal transition in human lung epithelial cells	2007
Dr Rachel Anderson Dr Lee Borthwick Dr James Lordan Professor Andrew Fisher	The effect of calcineurin inhibitors (CNI) on the release of secretory leucoproteinase inhibitor (SLPI) by lung epithelial cells in the presence of transforming growth factor-beta (TGF-beta)	2007
Dr Sean Parker Marta Gorowiec Dr Lee Borthwick Dr James Lordan Professor Christopher Ward et al.	Transforming growth factor beta (TGF beta) induces cellular senescence in primary bronchial epithelial cells: A possible role in airway remodelling	2007
Dr Lee Borthwick Professor Christopher Ward Dr James Lordan Professor Andrew Fisher	Epithelial mesencymal transition occurs in primary airway epithelial cells in response to transforming growth factor-beta and epidermal growth factor	2006
Dr Lee Borthwick Dr Sean Parker Professor Christopher Ward Dr James Lordan Professor Andrew Fisher et al.	Oxidative stress induces epithelial to mesenchymal transition in bronchial epithelial cells: A possible role in airway remodelling	2006
Dr Rachel Anderson Dr Lee Borthwick Dr James Lordan Professor Andrew Fisher	The effect of immunosuppressants on secretory leucoproteinase inhibitor production by lung epithelium in the presence of transforming growth factor-beta	2006
Dr Lee Borthwick Professor Christopher Ward Dr James Lordan Professor Andrew Fisher	Tumour necrosis factor-alpha accentuates transforming growth factor-beta driven epithelial to mesenchymal transition in lung epithelial cells	2006