Publications by Dr Arthur Pratt - ePrints

Browsing publications by Dr Arthur Pratt.

Newcastle Authors	Title	Year
Professor John Isaacs Dr Arthur Pratt Professor Christopher Buckley	Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial	2024
Philip Brown Dr Amy Anderson Najib Naamane Dr Dennis Lendrem Professor John Isaacs et al.	Adenosine metabolic signature in circulating CD4+ T cells predicts remission in rheumatoid arthritis	2024
Anthony McLean Dr Gary Reynolds Dr Arthur Pratt	Leveraging Multi-Tissue, Single-Cell Atlases as Tools to Elucidate Shared Mechanisms of Immune-Mediated Inflammatory Diseases	2024
Dr Abi Gault Dr Linda Hogarth Dr Kristian Williams Professor Alastair Greystoke Professor Neil Rajan et al.	Monitoring immunE DysregulAtion foLLowing Immune checkpOint-inhibitioN (MEDALLION): protocol for an observational cancer immunotherapy cohort study	2024
Dr Leher Gumber Dr Opeyemi Agbeleye Alex Inskip Ross Fairbairn Madeleine Still et al.	Operational complexities in international clinical trials: a systematic review of challenges and proposed solutions	2024
Professor John Isaacs Dr Arthur Pratt Dr Elena Nikiphorou	Personalised care packages for people with rheumatoid arthritis: a mixed-methods study	2024
Dr Ken Baker Dr David McDonald Dr Gill Hulme Raf Hussain Dr Jonathan Coxhead et al.	Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission	2024
Dr Arthur Pratt	Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials	2024
Philip Brown Dr Arthur Pratt	Therapeutic advances in rheumatoid arthritis	2024
Dr Arthur Pratt	Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes	2023
Gemma Vidal Pedrola Najib Naamane Dr Arthur Pratt Emeritus Professor Andrew Mellor Professor John Isaacs et al.	Characterization of age-associated B cells in early drug-naïve rheumatoid arthritis patients	2023
Dr Kristian Williams Abigail Gault Dr Amy Anderson Professor Christopher Stewart Professor Chris Lamb et al.	Immune-related adverse events in checkpoint blockade: Observations from human tissue and therapeutic considerations	2023
Dr Josh Bennett Dr Arthur Pratt Dr Richard Dodds Professor Avan Sayer Professor John Isaacs et al.	Rheumatoid sarcopenia: loss of skeletal muscle strength and mass in rheumatoid arthritis	2023
Najib Naamane Professor Heather Cordell Dr Arthur Pratt Professor Rachel Knevel	The Application of Genetic Risk Scores in Rheumatic Diseases: A Perspective	2023
Dr Arthur Pratt	The student patient alliance: development and formative evaluation of an initiative to support collaborations between patient and public involvement partners and doctoral students	2023
Dr Arthur Pratt Professor John Isaacs Dr Elena Nikiphorou	Association between social deprivation and disease activity in rheumatoid arthritis: a systematic literature review	2022
Dr Ken Baker Dr Dennis Lendrem Adam Scadeng Dr Ben Thompson Dr Arthur Pratt et al.	Erratum to "Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study" [J. Autoimmun. 105 (December 2019) 102298	2022
Dr Fiona Cooke Dr Mary Neal Dr Matthew Wood Dr Amy Anderson Julie Diboll et al.	Fluorine labelling of therapeutic human tolerogenic dendritic cells for 19F-magnetic resonance imaging	2022
Dr Arthur Pratt Professor John Isaacs	Impact of the COVID-19 pandemic on recruitment to clinical research studies in rheumatology	2022
Dr Faye Cooles Dr Jessica Tarn Dr Dennis Lendrem Najib Naamane Alice Lin et al.	Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming	2022
Professor James Wason Dr Arthur Pratt Professor John Isaacs Dr Elena Nikiphorou	Predictors of poor function in RA based on two prospective UK inception cohorts. Do comorbidities matter?	2022
Dr Arthur Pratt	Prospective Studies on the Risk of Rheumatoid Arthritis: The European Risk RA Registry	2022
Professor James Wason Dr Arthur Pratt Professor John Isaacs	The role of comorbidities alongside patient and disease characteristics on long-term disease activity in RA using UK inception cohort data	2022
Dr Richard Howey Alex Clark Najib Naamane Dr Louise Reynard Dr Arthur Pratt et al.	A Bayesian network approach incorporating imputation of missing data enables exploratory analysis of complex causal biological relationships	2021
Dr Fiona Rayner Dr Amy Anderson Dr Ken Baker Professor Christopher Buckley Dr Bernard Dyke et al.	BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study	2021
Abigail Gault Professor Christopher Stewart Dr Arthur Pratt Professor Neil Rajan	Cutaneous immune‐related adverse events in patients with melanoma treated with checkpoint inhibitors	2021
Leonie Schittenhelm Dr Arthur Pratt Professor Catharien Hilkens	Dendritic cell integrin expression patterns regulate inflammation in the rheumatoid arthritis joint	2021
Dr Ken Baker Dr Arthur Pratt Professor John Isaacs	Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs and Disease Flare in Patients with Rheumatoid Arthritis	2021
Dr Nicola Maney Dr Ben Barron-Millar Dr Christopher Carey Ian Herron Dr Amy Anderson et al.	Pim Kinases as Therapeutic Targets in Early Rheumatoid Arthritis	2021
Professor John Isaacs Dr Arthur Pratt	Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial	2021
Dr Arthur Pratt Dr Stefan Siebert Mike Cole Dr Deborah Stocken Amy Cranston et al.	Targeting synovial fibroblast proliferation in rheumatoid arthritis (TRAFIC): an open-label, dose-finding, phase 1b trial	2021
Dr Arthur Pratt Professor John Isaacs Dr Elena Nikiphorou	The use and context of the term 'multimorbidity' in rheumatoid arthritis: A systematic literature review	2021
Mike Cole Professor Fai Ng Dr Stefan Siebert Dr Arthur Pratt Professor John Isaacs et al.	TRAFIC: statistical design and analysis plan for a pragmatic early phase 1/2 Bayesian adaptive dose escalation trial in rheumatoid arthritis	2021
Dr Ken Baker Benjamin Thompson Dr Dennis Lendrem Adam Scadeng Dr Arthur Pratt et al.	Lack of association between clinical and ultrasound measures of disease activity in rheumatoid arthritis remission	2020
Alex Clark Dr Amy Anderson Dr Nishanthi Thalayasingam Najib Naamane Julie Diboll et al.	Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease loci	2020
Dr Dennis Lendrem Dr Clare Lendrem Dr Arthur Pratt Professor John Isaacs Professor David Jones et al.	Schrödinger's pipeline and the outsourcing of pharmaceutical innovation	2020
Dr Lilian Nwosu Dr Arthur Pratt Professor John Isaacs	Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis	2020
Dr Stefan Siebert Dr Arthur Pratt Dr Deborah Stocken Dr Miranda Patterson Amy Cranston et al.	Targeting the rheumatoid arthritis synovial fibroblast via cyclin dependent kinase inhibition: An early phase trial	2020
Professor John Isaacs Dr Arthur Pratt	Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol	2019
Dr Clare Lendrem Dr Dennis Lendrem Dr Arthur Pratt Najib Naamane Dr Peter McMeekin et al.	Between a ROC and a hard place: Teaching prevalence plots to understand real world biomarker performance in the clinic	2019
Dr Amy Anderson Dr Nicola Maney Dr Dennis Lendrem Julie Diboll Dr Philip Brown et al.	Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis	2019
Laura Ridgley Dr Amy Anderson Dr Nicola Maney Najib Naamane Andrew Skelton et al.	IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function	2019
Dr Matthew Wood Adam Leckenby Dr Gary Reynolds Dr Rachel Spiering Dr Arthur Pratt et al.	Macrophage proliferation distinguishes 2 subgroups of knee osteoarthritis patients	2019
Dr Ken Baker Andrew Skelton Dr Dennis Lendrem Adam Scadeng Dr Ben Thompson et al.	Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study	2019
Kundan Iqbal Dr Dennis Lendrem Ben Hargreaves Professor John Isaacs Dr Ben Thompson et al.	Routine musculoskeletal ultrasound findings impact diagnostic decisions maximally in autoantibody-seronegative early arthritis patients	2019
Dr Rachel Spiering Matthew Wood Anshor Fath Oliver Eltherington Dr Amy Anderson et al.	Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis	2019
Dr Nishanthi Thalayasingam Andrew Skelton Dr Amy Anderson Alex Clark Julie Diboll et al.	CD4+ and B lymphocyte expression quantitative traits at rheumatoid arthritis risk loci in untreated early arthritis: implications for causal gene identification	2018
Dr Ken Baker Dr Ben Thompson Dr Dennis Lendrem Dr Arthur Pratt Professor John Isaacs et al.	Lack of association between clinical and ultrasound measures of disease activity in rheumatoid arthritis clinical remission: a cross-sectional analysis	2018
Dr Arthur Pratt	Patient-reported outcomes and safety in patients undergoing synovial biopsy: Comparison of ultrasound-guided needle biopsy, ultrasound-guided portal and forceps and arthroscopic-guided synovial biopsy techniques in five centres across Europe	2018
Dr Faye Cooles Dr Amy Anderson Andrew Skelton Dr Arthur Pratt Professor Iain McInnes et al.	Phenotypic and transcriptomic analysis of peripheral blood plasmacytoid and conventional dendritic cells in early drug naïve rheumatoid arthritis	2018
Dr Ken Baker Dr Dennis Lendrem Dr Ben Thompson Dr Arthur Pratt Professor John Isaacs et al.	Predictors of drug-free remission in rheumatoid arthritis: results from the prospective Biomarkers of Remission in Rheumatoid Arthritis (BioRRA) Study	2018
Laura Ridgley Dr Amy Anderson Dr Arthur Pratt	What are the dominant cytokines in early rheumatoid arthritis?	2018
Professor Karim Raza Dr Arthur Pratt Helen Hanson Dr Stefan Siebert Professor John Isaacs et al.	Patient and researcher perspectives on facilitating patient and public involvement in rheumatology research	2017
Dr Ken Baker Dr Arthur Pratt Dr Ben Thompson Professor John Isaacs	Response to: 'Let's stop fooling ourselves. In RA, only ACR/EULAR criteria define remission and equate with absence of disease!' by Boers	2017
Professor John Isaacs Dr Arthur Pratt	Synovial tissue research: A state-of-the-art review	2017
Dr Faye Cooles Dr Amy Anderson Dr Dennis Lendrem Julie Norris Dr Arthur Pratt et al.	The interferon gene signature is increased in patients with early treatment-naive rheumatoid arthritis and predicts a poorer response to initial therapy	2017
Dr Amy Anderson Dr David Swan Oliver Eltherington Dr Arthur Pratt Dr Gary Reynolds et al.	Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4⁺ T-cells partly via TGF-β1	2017
Dr Arthur Pratt Dr Amy Anderson Professor John Isaacs	Bcl-3 in CD4+ T Cell–Mediated Rheumatoid Arthritis Pathogenesis: Comment on the Article by Meguro et al	2016
Dr Arthur Pratt Dr Amy Anderson Professor John Isaacs Julie Diboll Dr Nishanthi Thalayasingam et al.	Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23	2016
Dr Arthur Pratt Dr Dennis Lendrem Ben Hargreaves Professor John Isaacs	Components of treatment delay in rheumatoid arthritis differ according to autoantibody status: validation of a single-centre observation using national audit data	2016
Helen Hanson Professor John Isaacs Dr Lesley Kay Dr Dennis Lendrem Dr Nicola O'Brien et al.	Experiences of staff and patients in relation to clinical research recruitment and involvement: a qualitative study	2016
Dr Arthur Pratt Dr Amy Anderson Julie Diboll Andrew Skelton Dr Dennis Lendrem et al.	Identification of novel expression quantitative trait loci in CD4+ T cells of untreated early arthritis patients	2016
Dr Amy Anderson Dr Arthur Pratt Dr John Doran Christine Routledge Ben Hargreaves et al.	IL-6-driven STAT signalling in circulating CD4+ lymphocytes is a marker for early anti-citrullinated peptide antibody-negative rheumatoid arthritis	2016
Dr Philip Brown Dr Arthur Pratt Professor John Isaacs	Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers	2016
Dr Gary Reynolds Dr Arthur Pratt Dr David Coady Dr Graham Raftery Dr Alice Lorenzi et al.	Synovial CD4+ T-cell-derived GM-CSF supports the differentiation of an inflammatory dendritic cell population in rheumatoid arthritis	2016
Dr Ken Baker Benjamin Thompson Dr Dennis Lendrem Dr Arthur Pratt Professor John Isaacs et al.	Ultrasound measures of synovitis are independent of clinical parameters in the setting of rheumatoid arthritis remission: a cross-sectional analysis.	2016
Dr Arthur Pratt Ben Hargreaves Dr Dennis Lendrem Professor John Isaacs	Components of treatment delay in rheumatoid arthritis differ according to autoantibody status	2015
Dr Arthur Pratt Professor John Isaacs	Genotyping in rheumatoid arthritis: a game changer in clinical management?	2015
Dr Arthur Pratt Ben Hargreaves Christine Routledge Lesley Tiffin Julie Norris et al.	Reasons for Treatment Delay in Early Rheumatoid Arthritis Differ According to Autoantibody Status	2015
Dr Faye Cooles Dr Arthur Pratt Dr Dennis Lendrem Professor Fai Ng Dr Terry Aspray et al.	Retrospective analysis of the role of serum vitamin D in early rheumatic disease	2015
Dr Arthur Pratt Dr Amy Anderson Dr Dennis Lendrem Julie Diboll Ben Hargreaves et al.	STAT3-regulated gene expression in circulating CD4+ T cells discriminates RA patients independently of clinical parameters in early arthritis: a validation study.	2015
Dr Arthur Pratt Dr Amy Anderson Julie Diboll Andrew Skelton Ben Hargreaves et al.	The Importance of IL-6-STAT₃ Mediated Activation of Circulating CD4⁺ T Cells in the Pathogenesis of Early Seronegative Rheumatoid Arthritis: A Validation Study	2015
Sophie Noblett Dr Arthur Pratt Ben Hargreaves Christine Routledge Phil Mawson et al.	IL-6 Driven Stat3 Phophorylation in Circulating Lymphocytes is Specifiv for CD4⁺ T Cells in Early Rheumatoid Arthritis	2014
Dr Amy Anderson Christine Routledge Professor John Isaacs Dr Arthur Pratt	Investigation of interleukin-6-driven STAT3 signalling in circulating lymphocytes of patients with early rheumatoid arthritis as a route to biomarker discovery	2014
Dr Amy Anderson Dr Arthur Pratt Ben Hargreaves Philip Brown Professor John Isaacs et al.	Phospho-STAT1/3 and Gene Expression Measurement in Circulating CD4⁺ T Cells As Diagnostic Tools in Early Autoantibody-Negative Rheumatoid Arthritis	2014
Dr Amy Anderson Dr Arthur Pratt Ben Hargreaves Philip Brown Professor John Isaacs et al.	Phospho-STAT1/3 measurement in circulating CD4+T-cells as a diagnostic tool in early autoantibody-negative rheumatoid arthritis	2014
Dr Faye Cooles Dr Arthur Pratt Dr Dennis Lendrem Professor Fai Ng Dr Terry Aspray et al.	Retrospective analysis of the role of serum vitamin D in early rheumatic disease	2014
Dr Arthur Pratt Professor John Isaacs	Seronegative rheumatoid arthritis: Pathogenetic and therapeutic aspects	2014
Dr Arthur Pratt Dr Philip Brown Dr Simon Cockell Gillian Wilson Professor John Isaacs et al.	A CD4+T-Cell Gene Expression Signature Predicts Drug Survival on Methotrexate Monotherapy in Early Rheumatoid Arthritis	2013
Dr Amy Anderson Christine Routledge Phil Mawson Professor John Isaacs Dr Arthur Pratt et al.	Interleukin-6 driven STAT3 phosphorylation in circulating lymphocytes is specific for CD4 T cells in early rheumatoid arthritis	2013
Dr Amy Anderson Christine Routledge Phil Mawson Professor John Isaacs Dr Arthur Pratt et al.	Interleukin-6 Driven STAT3 Phosphorylation In Circulating Lymphocytes Is Specific For CD4⁺ T Cells In Early Rheumatoid Arthritis	2013
Dr Arthur Pratt Dr Alice Lorenzi Gillian Wilson Professor John Isaacs	Predicting persistent inflammatory arthritis amongst early arthritis clinic patients in the UK: is musculoskeletal ultrasound required?	2013
Dr Faye Cooles Dr Arthur Pratt Professor Fai Ng Dr Terry Aspray Professor John Isaacs et al.	The Effect Of Vitamin D On Early Rheumatoid Arthritis: A Retrospective Cohort Analysis	2013
Dr Arthur Pratt Dr Daniel Swan Dr Sarah Richardson Gillian Wilson Professor Catharien Hilkens et al.	A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly anti-citrullinated peptide antibody-negative disease	2012
Dr Arthur Pratt Dr Philip Brown Dr Simon Cockell Gillian Wilson Professor John Isaacs et al.	A CD4+T-Cell Gene Expression Signature Predicts Drug Survival On Methotrexate Monotherapy in Early Rheumatoid Arthritis.	2012
Dr Arthur Pratt Dr Alice Lorenzi Gillian Wilson Professor John Isaacs	A Pragmatic Musculoskeletal Ultrasound Screening Protocol Does Not Add to a Predictive Algorithm for Persistent Inflammatory Arthritis in a UK Early Arthritis Clinic	2012
Dr Amy Anderson Dr Alice Lorenzi Dr Arthur Pratt Thomas Wooldridge Julie Diboll et al.	Immunity 12 years after alemtuzumab in RA: CD5+ B-cell depletion, thymus-dependent T-cell reconstitution and normal vaccine responses	2012
Dr Arthur Pratt Professor Jaap Van Laar	Rheumatoid arthritis: Pathogenesis and clinical aspects	2012
Dr Arthur Pratt Dr Sarah Richardson Gillian Wilson Professor Catharien Hilkens Professor David Young et al.	A Transcriptional Profile Present in CD4+T-Cells of Patients with Undifferentiated Arthritis Predicts the Future Development of Seronegative Rheumatoid Arthritis and Implicates IL-6 in Disease Evolution	2011
Dr Arthur Pratt Dr Alice Lorenzi Dr Philip Platt Professor John Isaacs	Does routine musculoskeletal ultrasound use add value to the diagnosis of a RA among early and undifferentiated arthritis patients?	2011
Dr Arthur Pratt Professor John Isaacs	Does testing for circulating autoantibodies against disease-relevant citrullinated antigens add value to the CCP2 assay in diagnosing RA among early undifferenitated arthritis patients?	2011
Dr Arthur Pratt Professor John Isaacs	Does testing for circulating autoantibodies against disease-relevant citrullinated antigens add value to the CCP2 assay in diagnosing RA among early undifferentiated arthritis patients?	2011
Dr Faye Cooles Dr Arthur Pratt Dr Gillian Wilson Professor John Isaacs Professor Fai Ng et al.	Prevalence and diagnostic outcome relating to vitamin D deficiency in new patients presenting to an early arthritis clinic over 12 months	2011
Dr Arthur Pratt Professor John Isaacs	Serotyping for an extended anti-citrullinated peptide autoantibody panel does not add value to CCP2 testing for diagnosing RA in an early undifferentiated arthritis cohort	2011
Dr Arthur Pratt Dr Daniel Swan Dr Sarah Richardson Professor Catharien Hilkens Professor David Young et al.	Peripheral Blood CD4 T Cell Gene Expression Profiles as Predictive Biomarkers in Early Arthritis	2010
Dr Susan Tudhope Dr Alexei von Delwig Dr Jane Falconer Dr Arthur Pratt Professor John Isaacs et al.	Profound invariant natural killer T-cell deficiency in inflammatory arthritis	2010
Dr Arthur Pratt Dr Daniel Swan Professor David Young Professor Catharien Hilkens Professor John Isaacs et al.	A High-Throughput Transcriptomics Approach to Biomarker Discover in Early Arthritis	2009
Dr Alice Lorenzi Dr Angela Patterson Dr Arthur Pratt Dr Matthew Jefferson Professor John Isaacs et al.	Corrigendum to "Determination of thymic function directly from peripheral blood: A validated modification to an established method" [J. Immunol. Methods 2008 339(2):185-94] (DOI:10.1016/j.jim.2008.09.013)	2009
Dr Arthur Pratt Professor John Isaacs	Current concepts in the pathogenesis of early rheumatoid arthritis	2009
Dr Arthur Pratt Professor John Isaacs	The clinical utility of a rule for predicting rheumatoid arthritis in patients with early undifferentiated arthritis: comment on the article by van der Helm-van Mil et al	2009
Emeritus Professor Mike Sir Michael Rawlins Dr Angela Patterson Dr Arthur Pratt Dr Matthew Jefferson Professor John Isaacs et al.	Determination of thymic function directly from peripheral blood: a validated modification to an established method	2008
Dr Alexei von Delwig Dr Arthur Pratt Dr Susan Tudhope Professor John Isaacs Professor Fai Ng et al.	Invariant natural killer T (iNKT) cells in early rheumatoid arthritis (RA)	2008
Dr Alexei von Delwig Dr Susan Tudhope Dr Arthur Pratt Professor John Isaacs Dr Desa Lilic et al.	The role of invariant natural killer T (iNKT) cells in rheumatoid arthritis	2008
Dr Arthur Pratt Dr Lesley Kay	Comment on: Use of the QuantiFERON-TB® Gold test as part of a screening programme in patients with RA under consideration for treatment with anti-TNF-α agents: The Newcastle (UK) experience: Reply [7]	2007
Dr Arthur Pratt Dr Lesley Kay	Pamidronate infusions for Ankylosing Spondylitis give significant benefit to only a minority of patients	2007
Dr Arthur Pratt Dr Lesley Kay	Use of the QuantiFERON TB Gold test as part of a screening programme in patients with RA under consideration for treatment with anti-TNF-α agents: The Newcastle (UK) experience	2007
Dr Arthur Pratt Dr Lesley Kay	Use of the quantiFERON-TB gold test in pre-anti-TNF-alpha screening of rheumatoid arthritis patients: The newcastle experience	2006