Publications by Professor barbara Durkacz - ePrints

Browsing publications by Professor barbara Durkacz.

Newcastle Authors	Title	Year
Emily Mould Philip Berry Dr David Jamieson Dr Chris Hill Dr Celine Cano et al.	Identification of dual DNA-PK MDR1 inhibitors for the potentiation of cytotoxic drug activity	2014
Emily Mould Philip Berry Dr David Jamieson Dr Chris Hill Niu Tan et al.	The DNA-PK inhibitor, NU7441, sensitises cancer cells to microtubule-targeting agents and modulates vincristine efflux in multidrug resistant cells	2013
Dr Jill Hunter Dr Elaine Willmore Professor Julie Irving Dr Stephany Veuger Professor barbara Durkacz et al.	NF-kappa B mediates radio-sensitization by the PARP-1 inhibitor, AG-014699	2012
Dr Susan Tudhope Dr Evan Mulligan Dr Jill Hunter Dr Helen Marr Professor barbara Durkacz et al.	P B S-1086, a "Pan-Rel" Inhibitor, Decreases Viability of Chronic Lymphocytic Leukemia Cells	2012
Dr sarah Johnson Clark Crawford Dr Evan Mulligan Dr Jonathan Wallis Dr Tryfonia Mainou-Fowler et al.	Mitoxantrone in combination with an inhibitor of DNA-dependent kinase: a potential therapy for high risk B-cell chronic lymphocytic leukaemia	2011
Dr Stephany Veuger Professor barbara Durkacz	Persistence of unrepaired DNA double strand breaks caused by inhibition of ATM does not lead to radio-sensitisation in the absence of NF-kappa B activation	2011
Dr Elaine Willmore Dr Evan Mulligan Dr Sarah Elliott Professor barbara Durkacz	ATM Mutant Chronic Lymphocytic Leukaemia Cells are Chemosensitized by Inhibition of DNA Dependent Protein Kinase	2010
Dr sarah Johnson Dr Tryfonia Mainou-Fowler Professor barbara Durkacz Dr Elaine Willmore	Mitoxantrone in combination with an inhibitor of DNA-dependent protein kinase: A potential therapy for poor risk B-cell chronic lymphocytic leukaemia	2010
Dr Evan Mulligan Arabella Baird Dr Jonathan Wallis Dr Stephany Veuger Professor barbara Durkacz et al.	Relationships Between Aberrant Activity of the NF-kappa B Subunits and Outcome In Chronic Lymphocytic Leukemia: The Dual Role of DNA Damage Sensor Enzymes	2010
Dr Stephany Veuger Professor barbara Durkacz	Ionizing radiation-induced NF-kappaB activation requires PARP-1 function to confer radioresistance	2009
Dr Elaine Willmore Dr sarah Johnson Dr Tryfonia Mainou-Fowler Professor Graham Jackson Dr Celine Cano et al.	DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia	2008
Dr Elaine Willmore Dr sarah Johnson Clark Crawford Dr Tryfonia Mainou-Fowler Professor Graham Jackson et al.	DNA-Dependent Protein Kinase Is a Therapeutic Target in Poor Prognosis B-Cell Chronic Lymphocytic Leukemia	2008
Dr Ian Cowell Dr Nicola Sunter Professor Caroline Austin Professor barbara Durkacz Dr Michael Tilby et al.	γH2AX foci form preferentially in euchromatin after ionising-radiation	2007
Dr Elaine Willmore Professor Graham Jackson Dr Tryfonia Mainou-Fowler Professor Caroline Austin Professor barbara Durkacz et al.	Sensitisation of B-CLL cells to chlorambucil and fludarabine via inhibition of the DNA damage sensor proteins, DNA-PK and ATM	2006
Dr Elaine Willmore Dr Tryfonia Mainou-Fowler Professor Graham Jackson Professor barbara Durkacz	Targeting DNA-PK and ATM increases sensitivity to chlorambucil and fludarabine in chemoresistant and p53-defective B-CLL cells	2006
Dr Ian Cowell Professor barbara Durkacz Dr Michael Tilby	Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated	2005
Dr Elaine Willmore Dr Nicola Sunter Dr Michael Tilby Professor Graham Jackson Professor Caroline Austin et al.	A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia	2004
Dr Christopher Calabrese Michael Batey Professor Alan Calvert Professor barbara Durkacz Suzanne Kyle et al.	Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361	2004
Dr Stephany Veuger Professor Nicola Curtin Professor barbara Durkacz	Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair	2004
Dr Stephany Veuger Professor Nicola Curtin Professor barbara Durkacz	Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair	2004
Dr Stephany Veuger Professor barbara Durkacz	Improving breast cancer treatment using novel poly(ADP-ribose)	2004
Professor Nicola Curtin Lan Wang Suzanne Kyle Dr Christine Arris Professor barbara Durkacz et al.	Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells	2004
Dr Christopher Calabrese Michael Batey Huw Thomas Professor barbara Durkacz Lan Wang et al.	Identification of potent nontoxic poly(ADP-ribose) polymerase-1 inhibitors: Chemopotentiation and pharmacological studies	2003
Dr Stephany Veuger Professor Nicola Curtin Professor barbara Durkacz	Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1	2003
Dr Elaine Willmore Dr Michael Tilby Professor Caroline Austin Professor barbara Durkacz	Potentiation of topoisomerase II poison cytotoxicity in the K562 human leukaemia cell line by the novel DNA-dependent protein kinase inhibitor NU7026	2002
Professor Nicola Curtin Dr Stephen Barton Michael Batey Dr Christopher Calabrese Professor Alan Calvert et al.	Anti-cancer chemosensitization in vitro and in vivo by a novel potent poly(ADP-ribose) polymerase (PARP1) inhibitor, TBI-361.	2001
Dr Stephany Veuger Professor barbara Durkacz Emeritus Professor Bernard Golding Professor Roger Griffin Professor Herbie Newell et al.	Radiosensitization by novel inhibitors of PARP, PI, and DNA-PK, NU7026, in vitro	2001
Dr Paul Jowsey Gillian Farnie Professor barbara Durkacz Professor John Lunec	The dependence of p63 induction and activity on poly (ADP-ribose) polymerase-1	2001
Professor Nicola Curtin Professor Alan Calvert Professor barbara Durkacz Professor Roger Griffin Emeritus Professor Bernard Golding et al.	Chemopotentiation studies with two classes of potent (polyADP-ribose) polymerase (PARP) inhibitors in human lung and colon carcinoma cell lines.	2000
Suzanne Kyle Professor barbara Durkacz	Mechanisms of enhancement of cytotoxicity in etoposide and ionising radiation-treated cells by the protein kinase inhibitor wortmannin	2000
Lan Wang Suzanne Kyle Alex White Professor Alan Calvert Professor Nicola Curtin et al.	Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines	2000
Suzanne Kyle Professor barbara Durkacz	Cytotoxic mechanism of the protein kinase inhibitor wortmannin in ionising radiation and etoposide treated cells	1999
Suzanne Kyle Professor barbara Durkacz	Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage	1999
Professor Nicola Curtin Professor Alan Calvert Professor barbara Durkacz Professor Herbie Newell	Potentiation of temozolomide and topotecan cytotoxicity by PARP inhibitors in a panel of human cancer cell lines.	1999
Professor Nicola Curtin Suzanne Kyle Lan Wang Professor barbara Durkacz Professor Roger Griffin et al.	Potentiation of temozolomide and topotecan growth inhibition by novel potent benzimidazole poly(ADP-ribose) polymerase (PARP) inhibitors	1999
Suzanne Kyle Professor barbara Durkacz	Low nicotinamide mononucleotide adenylyltransferase activity in a tiazofurin-resistant cell line: Effects on NAD metabolism and DNA repair	1997
Suzanne Kyle Professor barbara Durkacz	Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells	1996
Professor Roger Griffin Professor Nicola Curtin Professor Herbie Newell Emeritus Professor Bernard Golding Professor barbara Durkacz et al.	The Role of Inhibitors of Poly(Adp-Ribose) Polymerase as Resistance-Modifying Agents in Cancer-Therapy	1995
Dr Elaine Willmore Professor barbara Durkacz	The effects of 5-fluoropyrimidines on nascent DNA synthesis in Chinese hamster ovary cells monitored by pH-step alkaline and neutral elution.	1994
Dr Elaine Willmore Professor barbara Durkacz	Cytotoxic mechanisms of 5-fluoropyrimidines: Relationships with poly(ADP-ribose) polymerase activity, DNA strand breakage and incorporation into nucleic acids	1993
Professor barbara Durkacz Professor John Lunec Professor Michael Griffin	Murine Melanoma Cell-Differentiation and Melanogenesis Induced by Poly(ADP-Ribose) Polymerase Inhibitors	1992
Professor barbara Durkacz	3-Aminobenzamide enhances base analog cytotoxicity by a mechanism independent of an inhibition of DNA repair	1990
Dr Elaine Willmore Professor barbara Durkacz	Correlation of enhanced 6-mercaptopurine cytotoxicity with increased phosphoribosylpyrophosphate levels in Chinese hamster ovary cells treated with 3-aminobenzamide	1990
Professor barbara Durkacz	Marked enhancement of base analog cyto-toxicity by 3-aminobenzamide: correlation with increased phosphotibosylpyrophospahte levels and augmented base salvage	1989
Professor barbara Durkacz	Adenosine-diphosphoribosyltransferase inhibitors can protect against or potentiate the cytotoxicity of S-phase acting drugs	1988
Professor barbara Durkacz	Synergistic enhancement of 6-thioguanine cytotoxicity by ADP-ribosyltransferase inhibitors	1988
Professor barbara Durkacz	ADP-ribosyl transferase inhibitors potentiate the cytotoxicity of base, but not nucleotide, analogs	1987
Professor barbara Durkacz	Inhibitors of ADP-ribosyl transferase protect against the cytotoxocity of S-phase acting drugs	1986