Publications by Lynne Minto - ePrints

Browsing publications by Lynne Minto.

Newcastle Authors	Title	Year
Dr Amir Enshaei Dr Sirintra Nakjang Lynne Minto Professor Julie Irving Beth Poole et al.	The genomic landscape of teenage and young adult T-cell acute lymphoblastic leukemia	2021
Dr Britta Vormoor Professor Gareth Veal Melanie Griffin Professor Julie Irving Lynne Minto et al.	A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia	2017
Professor Julie Irving Dr Amir Enshaei Dr Amy Erhorn Lynne Minto Claire Schwab et al.	Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukaemia	2016
Dr Sarra Ryan Elizabeth Matheson Dr Paul Sinclair Dr Matthew Bashton Claire Schwab et al.	The role of the RAS pathway in iAMP21-ALL	2016
Professor Anthony Moorman Professor Julie Irving Dr Amir Enshaei Dr Amy Erhorn Lynne Minto et al.	Composite Index for Risk Prediction in Relapsed Childhood Acute Lymphoblastic Leukaemia	2015
Dr Lindsay Nicholson Dr Emily Mavin Lynne Minto Professor Julie Irving Professor Anne Dickinson et al.	Gene Expression Profiling Implicates Attenuation of NFkB Signalling By Regulatory T Cells in Modulating Dendritic Cell Function	2015
Dr Lindsay Nicholson Dr Emily Mavin Lynne Minto Professor Julie Irving Professor Anne Dickinson et al.	Gene Expression Profiling Implicates Attenuation of NFkB Signalling By Regulatory T Cells in Modulating Dendritic Cell Function	2015
Dr Lindsay Nicholson Elizabeth Matheson Lynne Minto Christopher Keilty Maryna Sanichar et al.	Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re-sensitization by JNK inhibition	2015
Dr Lindsay Nicholson Elizabeth Matheson Lynne Minto Marian Case Maryna Sanichar et al.	Casitas B lymphoma mutations in childhood acute lymphoblastic leukemia	2012
Dr Vikki Rand Dr Lisa Russell Claire Schwab Hannah Ensor Professor Julie Irving et al.	Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia	2011
Dr Lindsay Nicholson Charlotte Evans Elizabeth Matheson Lynne Minto Christopher Keilty et al.	Quantitative Proteomic Analysis Reveals Maturation As a Mechanism Underlying Glucocorticoid Resistance in Childhood Acute Lymphoblastic Leukemia and PAX5 As a Re-Sensitising Therapeutic Target	2011
Dr Sarra Ryan Dr Vikki Rand Claire Schwab Heather Morrison Elizabeth Matheson et al.	Ras Signalling Pathway and Novel Target Genes Related to Down Syndrome Contribute to the Development of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in iAMP21 Patients	2011
Elizabeth Matheson Lynne Minto Dr Andrew Hall Professor Julie Irving	Mismatch repair and the downstream target genes, PAX5 and Ikaros, in childhood acute lymphoblastic leukemia	2010
Professor Julie Irving Marian Case Lynne Minto Sally Lawson	Establishment and validation of a standard protocol for the detection of minimal residual disease in B lineage childhood acute lymphoblastic leukemia by flow cytometry in a multi-center setting	2009
Kate Wilson Marian Case Lynne Minto Professor Simon Bailey Dr Nicholas Bown et al.	Flow minimal residue disease monitoring of candidate leukemic stem cells defined by the immunophenotype, CD34⁺CD38^lowCD19⁺ in B-lineage childhoood acute lymphoblastic leukemia	2009
Dr Lindsay Nicholson Elizabeth Matheson Lynne Minto Christopher Keilty Dr Andrew Hall et al.	Quantitative Proteomic Analysis Implicates An Altered B-Cell Differentiation State as a Mechanism Underlying GC-Resistance in An Acute Lymphoblastic Leukaemia (ALL) Cell Line Model	2009
Dr Vikki Rand Dr Lisa Russell Professor Julie Irving Lisa Jones Dr Dino Masic et al.	What Is the Initiating Mechanism of iAMP21 in Childhood B Cell Precursor ALL?	2009
Professor Julie Irving Lynne Minto Dr Andrew Hall	Genomic analysis of different clonal evolution in a twin pair with t(12;21) positive acute lymphoblastic leukemia sharing the same prenatal clone [8]	2008
Elizabeth Matheson Lynne Minto Professor Anthony Moorman Dr Andrew Hall Professor Julie Irving et al.	Heterogeneous breakpoints target PAX5 in acute lymphoblastic leukaemia patients with dicentric chromosomes	2008
Professor Anthony Moorman Sarina Sulong Professor Julie Irving Marian Case Lynne Minto et al.	Inactivation of CDKN2A in childhood acute lymphoblastic leukaemia (ALL) occurs principally by deletion and is strongly correlated with cytogenetic subgroups	2008
Marian Case Elizabeth Matheson Lynne Minto Dr Nicholas Bown Professor Simon Bailey et al.	Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia	2008
Marian Case Elizabeth Matheson Lynne Minto Professor Christine Harrison FRCPath FMedSci Dr Nicholas Bown et al.	Somatic mutation of genes impacting on the RAS-RAF-MEK-ERK pathway is the most common genetic abnormality in childhood acute lymphoblastic leukaemia, is implicated in disease progression and provides a rationale for therapeutic targeting	2008
Kerrie Wilson Marian Case Lynne Minto Professor Simon Bailey Professor Hermann Josef Vormoor et al.	The CD34⁺ CD38^Low CD19⁺ Candidate Leukemic Stem Cell Phenotype Revisited: Useful for Flow MRD Monitoring?	2008
Adillah Binti Yusof Professor Julie Irving Marian Case Lynne Minto Professor Christine Harrison FRCPath FMedSci et al.	Red blood cell alloimmunization is affected by depletion of donor white cell subsets	2007
Elizabeth Matheson Lynne Minto Professor Anthony Moorman Dr Andrew Hall Professor Julie Irving et al.	Variable Breakpoints Target PAX5 in Patients with Dicentric Chromosomes: A Model for the Basis of Unbalanced Translocations in Cancer	2007
Dr Andrew Hall Sarina Sulong Professor Christine Harrison FRCPath FMedSci Lynne Minto Dr Nicholas Bown et al.	Assessment of aneuploidy in childhood acute lymphoblastic leukaemia using high density oligonucleotide arrays.	2006
Sarina Sulong Professor Julie Irving Marian Case Lynne Minto Dr Nicholas Bown et al.	Comprehensive analysis of p16(INK4a) in childhood acute lymphoblastic leukemia reveals homozygous deletion, haploinsufficiency and acquired isodisomy at the 9p locus with intact p16(INK4a).	2006
Professor Julie Irving Lynne Minto Elizabeth Matheson Dr Lindsay Nicholson Dr Andrew Hall et al.	Glucocorticoid resistance in two key models of acute lymphoblastic leukemia occurs at the level of the glucocorticoid receptor	2006
Professor Julie Irving Lynne Minto Elizabeth Matheson Marian Case Professor Simon Bailey et al.	Mutation in genes impacting on the RAS-RAF-MEK-ERK pathway are found at high incidence in childhood acute lymphoblastic leukemia at both diagnosis and at relapse.	2006
Dr Andrew Hall Professor Julie Irving Lynne Minto	Reply to 'ATM variants and predisposition to childhood T-lineage acute lymphoblastic leukaemia' by Gumy-Pause et al. [6]	2006
Professor Julie Irving Lynne Minto Professor Simon Bailey Dr Andrew Hall	Loss of heterozygosity and somatic mutations of the Glucocorticoid receptor gene are rarely found at relapse in pediatric acute lymphoblastic leukemia but may occur in a subpopulation early in the disease course	2005
Monique Lhussier Lynne Minto	Paradoxes, locations and the need for social coherence: a qualitative study of living with a learning difficulty	2005
Dr Andrew Hall Professor Julie Irving Lynne Minto	Relation between genetic variants of the ataxia telangiectasia-mutated (ATM) gene, drug resistance, clinical outcome and predisposition to childhood T-lineage acute lymphoblastic leukaemia	2005
Sarina Sulong Marian Case Lynne Minto Dr Bridget Wilkins Dr Andrew Hall et al.	The V617F mutation in Jak2 is not found in childhood acute lymphoblastic leukaemia	2005
Dr Sandeep Pal Lynne Minto Dr Andrew Hall	Antibodies against 9-O-acetylated sialoglycans: A potent marker to monitor clinical status in childhood acute lymphoblastic leukemia	2004
Dr Andrew Hall Professor Julie Irving Lynne Minto	Genetic variants of ataxia telangiectasia mutated (ATM) and susceptibility for childhood T-lineage acute lymphoblastic leukemia.	2004
Professor Julie Irving Professor Stephen O'Brien Dr Anne Lennard Lynne Minto Dr Feng Lin et al.	Use of Denaturing HPLC for Detection of Mutations in the BCR-ABL Kinase Domain in Patients Resistant to Imatinib	2004
Dr Sally Coulthard Dr Linda Hogarth Dr Margaret Little Elizabeth Matheson Dr Chris Redfern et al.	The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs	2002
Dr Linda Hogarth Lynne Minto	Enhanced expression and activity of DNA polymerase β in human ovarian tumor cells: impact on sensitivity towards antitumor agents	2001
Dr Linda Hogarth Dr Margaret Little Lynne Minto Dr Chris Redfern Dr Andrew Hall et al.	High thiopurine methyltransferase expression confers different levels of resistance with 6-thioguanine compared to 6-mercaptopurine.	2001
Dr Linda Hogarth Dr Margaret Little Lynne Minto Dr Chris Redfern Dr Andrew Hall et al.	In vitro evidence for differences in 6-mercaptopurine versus 6-thioguanine metabolism depending on TPMT status	2001
Dr Andrew Hall Dr Peter Hamilton Lynne Minto Dr Sally Coulthard	The use of denaturing high-pressure liquid chromatography for the detection of mutations in thiopurine methyltransferase	2001
Dr Sally Coulthard Dr Christopher Howell Lynne Minto Dr Peter Middleton Professor Graham Jackson et al.	A comparison of molecular and enzyme-based assays for the detection of thiopurine methyltransferase mutations	2000
Dr Sally Coulthard Dr Linda Hogarth Lynne Minto Dr Chris Redfern Dr Andrew Hall et al.	High thiopurine methyltransferase expression confers different levels of resistance with 6-thioguanine compared to 6-mercaptopurine	2000
Dr Linda Hogarth Elizabeth Matheson Lynne Minto Dr Margaret Little Dr Andrew Hall et al.	Measurement of resistance to thiopurine drugs in cells with defective mismatch repair	2000