Publications by Professor Michael Briggs - ePrints

Browsing publications by Professor Michael Briggs.

Newcastle Authors	Title	Year
Dr Ella Dennis Professor Michael Briggs	Curcumin Reduces Pathological Endoplasmic Reticulum Stress through Increasing Proteolysis of Mutant Matrilin-3	2023
Adam Duxfield Dr Jennifer Munkley Professor Michael Briggs Dr Ella Dennis	CRELD2 is a novel modulator of calcium release and calcineurin-NFAT signalling during osteoclast differentiation	2022
Dan Hayman Dr Tamara Modebadze Sarah Charlton Kat Cheung Dr Jamie Soul et al.	Increased hippocampal excitability in miR-324-null mice	2021
Dr Ella Dennis Professor Michael Briggs	Multiple epiphyseal dysplasia and related disorders: Molecular genetics, disease mechanisms, and therapeutic avenues	2021
Dr Ella Dennis Robert Jackson Dr Dimitra Tsompani Professor David Young Dr Katarzyna Pirog et al.	CRELD2 is a novel LRP1 chaperone that regulates non-canonical WNT signalling in skeletal development	2020
Professor Michael Briggs Dr Ella Dennis Helen Dietmar Dr Katarzyna Pirog	New developments in chondrocyte ER-stress and related diseases	2020
Dr Jamie Soul Professor Michael Briggs	Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis	2019
Dr Katarzyna Pirog Dr Ella Dennis Robert Jackson Dr Jamie Soul Professor Michael Briggs et al.	XBP1 signalling is essential for alleviating mutant protein aggregation in ER-stress related skeletal disease.	2019
Dr Peter Bell Dr Ella Dennis Robert Jackson Dr Anna Porter Dr Katarzyna Pirog et al.	Mesencephalic astrocyte-derived neurotrophic factor is an important factor in chondrocyte ER homeostasis	2018
Professor Michael Briggs	Increased intracellular proteolysis reduces disease severity in an ER stress-associated dwarfism	2017
Professor Michael Briggs Dr Peter Bell Dr Katarzyna Pirog	Pseudoachondroplasia and Multiple Epiphyseal Dysplasia: Molecular Genetics, Disease Mechanisms and Therapeutic Targets.	2017
Professor Michael Briggs	ER stress: a new regulator of chondrocyte biology and cartilage health	2016
Dr Beth Gibson Professor Michael Briggs	The aggrecanopathies; an evolving phenotypic spectrum of human genetic skeletal diseases	2016
Dr Ella Dennis Dr Katarzyna Pirog Professor Michael Briggs	The role of Creld2 in skeletal development and homeostasis	2016
Dr Katarzyna Pirog Professor Michael Briggs	Cartilage-Specific Ablation of XBP1 Signaling in Mouse Results in a Chondrodysplasia Characterized by Reduced Chondrocyte Proliferation and Delayed Cartilage Maturation and Mineralization	2015
Professor Michael Briggs	Increased Classical Endoplasmic Reticulum Stress Is Sufficient to Reduce Chondrocyte Proliferation Rate in the Growth Plate and Decrease Bone Growth	2015
Robert Jackson Dr Peter Bell Professor Michael Briggs	Molecular mechanisms provide new insight on genotype to phenotype correlations in type II collagenopathies	2015
Professor Michael Briggs Dr Peter Bell Dr Michael Wright Dr Katarzyna Pirog	New therapeutic targets in rare genetic skeletal diseases	2015
Dr Ella Dennis Dr Katarzyna Pirog Professor Michael Briggs	The role of CRELD2 in skeletal development and homeostasis	2015
Professor Michael Briggs Dr Peter Bell Dr Katarzyna Pirog	The utility of mouse models to provide information regarding the pathomolecular mechanisms in human genetic skeletal diseases: The emerging role of endoplasmic reticulum stress (Review)	2015
Dr Beth Gibson Dr Katarzyna Pirog Professor Michael Briggs	Transgenic mice with an allelic series of aggrecan mutations model the human phenotypes	2015
Dr Katarzyna Pirog Stacy Young Dr Peter Bell Professor Michael Briggs	Abnormal Chondrocyte Apoptosis in the Cartilage Growth Plate is Influenced by Genetic Background and Deletion of CHOP in a Targeted Mouse Model of Pseudoachondroplasia	2014
Professor Michael Briggs Dr Peter Bell	Genotype to phenotype correlations in cartilage oligomeric matrix protein associated chondrodysplasias	2014
Dr Benedetta Gualeni Dr Peter Bell Professor Michael Briggs	A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth	2013
Dr Peter Bell Professor Michael Briggs	Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures	2013
Dr Peter Bell Professor Michael Briggs	Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases	2013
Professor Michael Briggs	Chondrocyte ER stress as a pathogenic factor in osteoarthritis	2013
Dr Katarzyna Pirog Professor Michael Briggs	Mild myopathy is associated with COMP but not MATN3 mutations in mouse models of genetic skeletal diseases	2013
Dr Katarzyna Pirog Professor Michael Briggs	Mutant chondrocytes are characterised by altered cell shape and changes to the organisation of primary cilia in a genetic mouse model of mild pseudoachondroplasia	2013
Dr Katarzyna Pirog Professor Michael Briggs	A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia	2012
Dr Peter Bell Dr Katarzyna Pirog Professor Michael Briggs	Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation	2012
Professor Michael Briggs	Pseudoachondroplasia and multiple epiphyseal dysplasia: A 7-year comprehensive analysis of the known disease genes identify novel and recurrent mutations and provides an accurate assessment of their relative contribution	2012
Professor Michael Briggs	Recurrent Dominant Mutations Affecting Two Adjacent Residues in the Motor Domain of the Monomeric Kinesin KIF22 Result in Skeletal Dysplasia and Joint Laxity (vol 89, pg 769, 2011)	2012
Professor Michael Briggs	Recurrent Dominant Mutations Affecting Two Adjacent Residues in the Motor Domain of the Monomeric Kinesin KIF22 Result in Skeletal Dysplasia and Joint Laxity	2011
Dr Katarzyna Pirog Professor Michael Briggs	A mouse model offers novel insights into the myopathy and tendinopathy often associated with pseudoachondroplasia and multiple epiphyseal dysplasia	2010
Dr Peter Bell Professor Michael Briggs	An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia	2010
Professor Michael Briggs	Correlating endoplasmic reticulum stress with the onset of disease phenotype in chondrodysplasias	2010
Dr Katarzyna Pirog Professor Michael Briggs	Molecular dissection of the unfolded protein response in hypertrophic chondrocytes	2010
Dr Katarzyna Pirog Professor Michael Briggs	Skeletal Dysplasias Associated with Mild Myopathy-A Clinical and Molecular Review	2010
Professor Michael Briggs	Structural ad functional investigations of Matrillin-1 a-domains reveal insights into their role in cartilage ECM assembly	2010
Professor Michael Briggs	The unfolded protein response and its relevance to connective tissue diseases	2010
Professor Michael Briggs	Type IX Collagen Gene Mutations can result in Multiple Epiphyseal Dysplasia that is associated with Osteochondritis Dissecans and a Mild Myopathy	2010
Dr Stuart Tompson Professor Michael Briggs	A Recessive Skeletal Dysplasia, SEMD Aggrecan Type, Results from a Missense Mutation Affecting the C-Type Lectin Domain of Aggrecan	2009
Professor Michael Briggs	Collagen XXVII mutations cause a lung phenotype and plays a role in growth plate architecture	2009
Dr Katarzyna Pirog Professor Michael Briggs	Genetic background influences the severity of chondrodysplasia phenotype	2009
Professor Michael Briggs	Targeted induction of endoplasmic reticulum stress induces cartilage pathology	2009
Professor Michael Briggs	Targeted type XXVII collagen mutations cause lung and skeletal phenotypes	2008
Professor Michael Briggs	Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens	2007
Professor Michael Briggs	Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation	2007
Professor Michael Briggs	Gene targeting collagen XXVII	2007
Dr Katarzyna Pirog Professor Michael Briggs	Genetic background influences the severity of growth plate dysplasia in a mouse model of pseudoachondroplasia	2007
Dr Katarzyna Pirog Professor Michael Briggs	Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP	2007
Professor Michael Briggs	Structural and functional characterization of recombinant matrilin-3 A-domain and implications for human genetic bone diseases	2007
Professor Michael Briggs	The effects of an MCDS-causing mutation on chondrocyte proliferation in mouse growth plate	2007
Professor Michael Briggs	The genetics of otosclerosis: pedigree studies and linkage analysis	2007
Professor Michael Briggs	A Knockin mouse model for a collagen type X NC1 domain mutation associated with metaphyseal chondrodysplasia-type Schmid	2006
Professor Michael Briggs	A matrilin-3 multiple epiphyseal dysplasia knockin mouse model	2006
Professor Michael Briggs	Characterization of collagen XXVII, a new collagen with a domain structure homologous to the fibrillar collagens	2006
Dr Katarzyna Pirog Professor Michael Briggs	T583M COMP knockin mouse - a model of mild pseudoachondroplasia resulting from C-terminal COMP mutation	2006
Professor Michael Briggs	A disorder resembling pseudoachondroplasia but without COMP mutation	2005
Professor Michael Briggs	A knock-in mouse model for a collagen type X NC1 domain mutation associated with metaphyseal chondrodysplasia type Schmid (MCDS)	2005
Professor Michael Briggs	A knock-in mouse model for a collagen type X NC1 domain mutation associated with metaphyseal chondrodysplasia-type Schmid	2005
Professor Michael Briggs	Multiple epiphyseal dysplasia mutations in MATN3 cause misfolding of the A-domain and prevent secretion of mutant matrilin-3	2005
Professor Michael Briggs	Mutations in the known genes are not the major cause of MED; distinctive phenotypic entities among patients with no identified mutations	2005
Professor Michael Briggs	Novel and recurrent mutations in the C-terminal domain of COMP cluster in two distinct regions and result in a spectrum of phenotypes within the pseudoachondroplasia – multiple epiphyseal dysplasia disease group	2005
Professor Michael Briggs	Review: Clinical variability and genetic heterogeneity in multiple epiphyseal dysplasia	2003
Professor Michael Briggs	Structural and functional changes in collagen IX due to a MED mutation	2003
Professor Michael Briggs	Pseudoachondroplasia and multiple epiphyseal dysplasia: Mutation review, molecular interactions, and genotype to phenotype correlations	2002
Professor Michael Briggs	Cartilage oligomeric matrix protein interacts with type IX collagen, and disruptions to these interactions identify a pathogenetic mechanism in a bone dysplasia family	2001
Professor Michael Briggs	Clinical and radiographic features of multiple epiphyseal dysplasia not linked to the COMP or type IX collagen genes	2001
Professor Michael Briggs	Multiple epiphyseal dysplasia: radiographic abnormalities correlated with genotype	2001
Professor Michael Briggs Professor John Loughlin	Mutations in the vWFA domain of matrilin-3 cause multiple epiphyseal dysplasia	2001
Professor Michael Briggs Matthew Wright	Update from the collaborative study of genetic diagnosis for skeletal dysplasias	2001
Professor Michael Briggs	Exon skipping mutation in the COL9A2 gene in a family with multiple epiphyseal dysplasia	2000
Professor Michael Briggs	Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix	2000
Professor Michael Briggs	Molecular diagnosis is important to confirm suspected pseudoachondroplasia	2000
Professor Michael Briggs	Screening for mutations in cartilage ECM genes	2000
Professor Michael Briggs	Clinical variability and genetic heterogeneity in multiple epiphyseal dysplasia	1999
Professor Michael Briggs	COMP gene mutations result in abnormal collagen fibril morphology	1999
Professor John Loughlin Professor Michael Briggs	Identification of novel pro-alpha 2(IX) collagen gene mutations in two families with distinctive olgo-epiphyseal forms of multiple epiphyseal dysplasia	1999
Professor Michael Briggs	Trinucleotide expansion mutations in the cartilage oligomeric matrix protein (COMP) gene	1999