Publications by Professor Neil Perkins - ePrints

Browsing publications by Professor Neil Perkins.

Newcastle Authors	Title	Year
Sara Cuevas Ocaña Dr George Schlossmacher Professor Neil Perkins Dr Michael Gray	A Cell-Based Optimised Approach for Rapid and Efficient Gene Editing of Human Pluripotent Stem Cells	2023
Dr Jack Leslie Dr Jill Hunter Amy Collins Amelia Rushton Lauren Russell et al.	c-Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis	2023
Dr Suzanne Madgwick Dr Saimir Luli Helene Sellier Dr Jacqueline Butterworth Dr Jack Leslie et al.	Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential	2022
Dr Jill Hunter Dr Jacqueline Butterworth Helene Sellier Dr Nicola Hannaway Dr Saimir Luli et al.	Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance	2022
Dr Jill Hunter Dr Nicola Hannaway Scott Kerridge Dr Saimir Luli Dr Jacqueline Butterworth et al.	Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway	2022
Dr Jill Hunter Scott Kerridge Dr Nicola Hannaway Dr Saimir Luli Dr Iglika Ivanova et al.	Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells	2022
Dr Jill Hunter Lucy Salmon Dr Caroline Wilson Professor Neil Perkins Dr Owen Davies et al.	Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12	2021
Dr Ling-I Su Emma Corbin Professor Neil Perkins	Temporal modulation of the NF-B RelA network in response to different types of DNA damage	2021
Dr Gema Dura Dr Daniel Peters Dr Helen Waller Dr Adrian Yemm Professor Neil Perkins et al.	A thermally reformable protein polymer	2020
Anna Smith Dr Julia Whitehall Carla Bradshaw Dr Fiona Robertson Dr Alasdair Blain et al.	Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis	2020
Dr Iglika Ivanova Professor Neil Perkins	Hypoxia induces rapid, STAT3 and ROS dependent, mitochondrial translocation of RelA(p65) and IκBα	2019
Majeed Al-Jawdah Dr Iglika Ivanova Dr Helen Waller Professor Neil Perkins Professor Jeremy Lakey et al.	Induction of the immunoprotective coat of Yersinia pestis at body temperature is mediated by the Caf1R transcription factor	2019
Dr Katarzyna Szoltysek Dr Simon Cockell Professor Neil Perkins	RRAD, IL4I1, CDKN1A, and SERPINE1 genes are potentially co-regulated by NF-κB and p53 transcription factors in cells exposed to high doses of ionizing radiation	2018
Professor Neil Perkins	More than just an IκB kinase: the IKK complex coordinates mRNA stability and transcription	2018
Dr Anna Moles Fernandez Dr Jacqueline Butterworth Dr Jill Hunter Dr Jack Leslie Helene Sellier et al.	A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-kB dependent liver regeneration and cancer	2016
Dr Jill Hunter Jack Leslie Professor Neil Perkins	c-Rel and its many roles in cancer: an old story with new twists	2016
Dr Tyrell Cartwright Professor Neil Perkins Dr Caroline Wilson	NFKB1: a suppressor of inflammation, ageing and cancer	2016
Dr Jill Hunter Professor Neil Perkins	The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eμ-MYC driven B-cell lymphoma	2016
Dr Jill Hunter Dr Jacqueline Butterworth Helene Sellier Huw Thomas Dr Christopher Bacon et al.	The NF-κB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma	2016
Dr Anna Moles Fernandez Dr Jacqueline Butterworth Dr Jill Hunter Professor Derek Mann Professor Fiona Oakley et al.	Mutation of Rela THR505 Enhances Liver Regeneration Following Partial Hepatectomy	2015
Dr Elaine Willmore Dr Aaron Ions Gardner Dr Susan Tudhope Belinda Murtani Jessica Caffry et al.	Novel small molecule IKK alpha inhibitors inhibit non- canonical NF-kappa B signaling and survival of primary CLL cells	2015
Professor Neil Perkins	The importance of the p50 NF-κB subunit	2015
Dr Anna Moles Fernandez Dr Jacqueline Butterworth Dr Jill Hunter Dr Dina Tiniakos Professor Derek Mann et al.	Thr505 RelA phosphorylation controls liver proliferative response and supresses NF-kappa B tumor-promoting activities	2015
Dr Adeline Ledoux Dr Jill Hunter Professor Neil Perkins	Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy	2014
Professor Neil Perkins	Identification of New Mechanisms of Cellular Response to Chemotherapy by Tracking Changes in Post-Translational Modifications by Ubiquitin and Ubiquitin-Like Proteins	2014
Dr Adeline Ledoux Professor Neil Perkins	NF-_kB and the cell cycle	2014
Professor Neil Perkins	NF-kappa B is a critical mediator of BRCA1-induced chemoresistance	2014
Dr Alessio Iannetti Dr Adeline Ledoux Dr Susan Tudhope Helene Sellier Adam Moore et al.	Regulation of p53 and Rb Links the Alternative NF-kappaB Pathway to EZH2 Expression and Cell Senescence	2014
Dr Jill Hunter Dr Jacqueline Butterworth Professor Neil Perkins Professor Melissa Bateson Dr Claire Richardson et al.	Using body temperature, food and water consumption as biomarkers of disease progression in mice with Eμ-myc lymphoma	2014
Professor Neil Perkins	Emerging from NF-kappa B's Shadow, SUMOylated I kappa B alpha Represses Transcription	2013
Professor Neil Perkins	Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence	2013
Professor Neil Perkins	Identification and Functional Characterization of FMN2, a Regulator of the Cyclin-Dependent Kinase Inhibitor p21	2013
Dr Lindsay Murphy Dr Saimir Luli Dr Lee Borthwick Dr Steven O'Reilly Professor Neil Perkins et al.	Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response	2013
Dr Adeline Ledoux Helene Sellier Dr Alessio Iannetti Professor Neil Perkins	NF kappa B regulates expression of Polo-like kinase 4	2013
Professor Fiona Oakley Professor Neil Perkins	BAG-1 interacts with the p50-p50 homodimeric NF-kappa B complex: implications for colorectal carcinogenesis	2012
Professor Neil Perkins	Cysteine 38 Holds the Key to NF-kappa B Activation	2012
Dr Renee Johnson Professor Neil Perkins	Nuclear factor-kappa B, p53, and mitochondria: regulation of cellular metabolism and the Warburg effect	2012
Professor Neil Perkins	The diverse and complex roles of NF-kappa B subunits in cancer.	2012
Dr Renee Johnson Professor Neil Perkins	p53-dependent regulation of mitochondrial energy production by the RelA subunit of NF-κB	2011
Professor Neil Perkins Dr Renee Johnson	The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration	2011
Professor Neil Perkins	p53-dependent repression of polo-like kinase-1 (PLK1)	2010
Professor Neil Perkins	Regulation of cyclin D1 gene expression	2010
Professor Neil Perkins	Thr(435) phosphorylation regulates RelA (p65) NF-kappa B subunit transactivation	2010
Professor Neil Perkins	[abstract] Regulation of cancer cell proliferation and survival by NF-kappa B	2009
Professor Neil Perkins	Getting away from it all in Capri: the 2008 EMBO workshop on NF-kappa B	2009
Professor Neil Perkins	A238L inhibits NF-ATc2, NF-kappa B, and c-Jun activation through a novel mechanism involving protein kinase C-theta-mediated up-regulation of the amino-terminal transactivation domain of p300	2008
Professor Neil Perkins	IEX-1 directly interferes with RelA/p65 dependent transactivation and regulation of apoptosis	2008
Professor Neil Perkins	Regulation of cyclin D1 RNA stability by SNIP1	2008
Professor Neil Perkins	Regulation of the ReIA (p65) transactivation domain	2008
Professor Neil Perkins	Integrating cell-signalling pathways with NF-kappaB and IKK function	2007
Professor Neil Perkins	p53 and NF-κB crosstalk: IKKα tips the balance	2007
Professor Neil Perkins	Proenkephalin assists stress-activated apoptosis through transcriptional repression of NF-kappaB- and p53-regulated gene targets	2007
Professor Neil Perkins	Regulation of ATR-dependent pathways by the FHA domain containing protein SNIP1	2007
Professor Neil Perkins	Transcriptional profiling of the LPS induced NF-κB response in macrophages	2007
Professor Neil Perkins	Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappaB transactivation	2006
Professor Neil Perkins	Differential regulation of NF-κB activation and function by topoisomerase II inhibitors	2006
Professor Neil Perkins	Good cop, bad cop: the different faces of NF-kappaB	2006
Professor Neil Perkins	Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway	2006
Professor Neil Perkins	Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit	2006
Professor Neil Perkins	SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes	2006
Professor Neil Perkins	ARF the integrator: linking NF-kappaB, p53 and checkpoint kinases	2005
Professor Neil Perkins	Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism	2005
Professor Neil Perkins	Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases	2005
Professor Neil Perkins	p21(WAF1/CIP1) regulates the p300 sumoylation motif CRD1 through a C-terminal domain independently of Cyclin/CDK binding	2005
Professor Neil Perkins	Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor	2005
Professor Neil Perkins	Regulation of NF-kappaB function	2005
Professor Neil Perkins	SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1	2005
Professor Neil Perkins	The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor	2005