Saad Aldalaqan Caroline Dalgliesh Dr Sara Luzzi Chile Siachisumo Dr Louise Reynard et al. | Cryptic splicing: common pathological mechanisms involved in male infertility and neuronal diseases | 2022 |
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Dr Faye Cooles Dr Jessica Tarn Dr Dennis Lendrem Najib Naamane Alice Lin et al. | Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming | 2022 |
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Dr Richard Howey Alex Clark Najib Naamane Dr Louise Reynard Dr Arthur Pratt et al. | A Bayesian network approach incorporating imputation of missing data enables exploratory analysis of complex causal biological relationships | 2021 |
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Dr Matthew Barter Dr Catherine Bui Kat Cheung Julia Falk Dr Rodolfo Gomez et al. | DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions | 2020 |
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Kat Cheung Dr Matthew Barter Julia Falk Dr Carole Proctor Dr Louise Reynard et al. | Histone ChIP-Seq identifies differential enhancer usage during chondrogenesis as critical for defining cell-type specificity | 2020 |
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Alex Clark Dr Amy Anderson Dr Nishanthi Thalayasingam Najib Naamane Julie Diboll et al. | Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease loci | 2020 |
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Sam Charlton Kat Cheung Yao Hao Dr Jamie Soul Dr Louise Reynard et al. | microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs | 2020 |
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Kat Cheung Marjolein Burgers Professor David Young Dr Simon Cockell Dr Louise Reynard et al. | Correlation of Infinium HumanMethylation450K and MethylationEPIC BeadChip arrays in cartilage | 2019 |
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Dr Sarah Rice Kat Cheung Dr Louise Reynard Professor John Loughlin
| Discovery and analysis of methylation quantitative trait loci (mQTLs) mapping to novel osteoarthritis genetic risk signals | 2019 |
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Dr Colin Shepherd Abi Reese Dr Louise Reynard Professor John Loughlin
| Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP | 2019 |
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Dr Sarah Rice Kat Cheung Dr Louise Reynard Professor John Loughlin
| Identification and analysis of novel methylation quantitative trait loci (mQTLs) in osteoarthritis | 2019 |
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Dr Louise Reynard Dr Matthew Barter
| Osteoarthritis year in review 2019: genetics, genomics and epigenetics | 2019 |
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Dr Sarah Rice Maria Tselepi Dr Tony Sorial Guillaume Aubourg Dr Colin Shepherd et al. | Prioritization of PLEC and GRINA as osteoarthritis risk genes through the identification and characterization of novel methylation quantitative trait loci | 2019 |
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Dr Nishanthi Thalayasingam Andrew Skelton Dr Amy Anderson Alex Clark Julie Diboll et al. | CD4+ and B lymphocyte expression quantitative traits at rheumatoid arthritis risk loci in untreated early arthritis: implications for causal gene identification | 2018 |
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Chris Macdonald Dr Adrian Falconer Dr Chun Chan Dr David Wilkinson Andrew Skelton et al. | Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to MMP1 expression in human chondrocytes | 2018 |
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Dr Colin Shepherd Dr Dongxing Zhu Andrew Skelton Dr Louise Reynard Professor John Loughlin et al. | Functional characterization of the osteoarthritis genetic risk residing at ALDH1A2 identifies rs12915901 as a key target variant. | 2018 |
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Dr Colin Shepherd Dr Louise Reynard Professor John Loughlin
| Genotype at the MGP OA risk locus correlates with an expression quantitative trait locus operating on MGP in cartilage and with DNA methylation at a cluster of regulatory CpGs within ARHGDIB | 2018 |
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Dr Sarah Rice Guillaume Aubourg Dr Tony Sorial Dr David Almarza Gomez Maria Tselepi et al. | Identification of a novel, methylation-dependent, RUNX2 regulatory region associated with osteoarthritis risk | 2018 |
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Dr Sarah Rice Dr Tony Sorial Guillaume Aubourg Dr Colin Shepherd Maria Tselepi et al. | Identification of novel methylation quantitative trait loci (mqtls) and functional characterization using CRISPR/CAS9 and gene expression analysis prioritizes PLEC as an OA risk gene | 2018 |
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Dr Madhushika Ratnayake Maria Tselepi Dr Louise Reynard Professor John Loughlin
| A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5 | 2017 |
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Dr Louise Reynard
| Analysis of genetics and DNA methylation in osteoarthritis: What have we learnt about the disease? | 2017 |
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Dr Sarah Rice Guillaume Aubourg Dr Tony Sorial Professor David Deehan Professor John Loughlin et al. | Epigenetic and transcriptional effects operate on the SUPT3H and RUNX2 genes residing at the chromosome 6p21.1 osteoarthritis susceptibility locus and correlate with the association signal | 2017 |
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Dr Colin Shepherd Dr Dongxing Zhu Andrew Skelton Dr Louise Reynard Professor John Loughlin et al. | Functional characterisation of the osteoarthritis genetic risk locus that resides at the gene ALDH1A2, coding for the retinoic acid synthesis enzyme RALDH2, identifies rs4646636 and rs12915901 as key target SNPs | 2017 |
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Dr Louise Reynard Andrew Skelton David Young Professor John Loughlin
| The first international workshop on the epigenetics of osteoarthritis | 2017 |
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Dr Louise Reynard Dr Amanda Villalvilla Garcia Professor John Loughlin
| Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis | 2017 |
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Andrew Skelton Dr Rodolfo Gomez Professor John Loughlin Dr Louise Reynard
| Age-related DNA methylation changes in normal and osteoarthritis cartilage | 2016 |
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Dr Tarana Singh Dang Dr Joe Willet Helen Griffin Dr Graeme O'Boyle Dr Mario Abinun et al. | Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency | 2016 |
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Maria Tselepi Madhushika Ratnayake Dr Louise Reynard Professor John Loughlin
| Differences in the response of mesenchymal stem cells from healthy donors and OA patients to exogenous GDF5 during chondrogenic differentiation | 2016 |
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Dr Amanda Villalvilla Garcia Dr Fiona Gee Professor John Loughlin Dr Louise Reynard
| DNA methylation in the 20q13 OA susceptibility region marked by rs6094710 is associated with modulation of NCOA3 gene expression | 2016 |
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Dr Tarana Singh Dang Dr Joe Willet Helen Griffin Dr Graeme O'Boyle Dr Mario Abinun et al. | Erratum to: Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency (vol 36, pg 117, 2016) | 2016 |
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Dr Colin Shepherd Andrew Skelton Dr Michael Rushton Dr Louise Reynard Professor John Loughlin et al. | Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874 | 2016 |
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Dr Louise Reynard Dr Madhushika Ratnayake Dr Mauro Santibanez Koref Professor John Loughlin
| Functional characterization of the osteoarthritis susceptibility mapping to CHST11 - a bioinformatics and molecular study | 2016 |
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Emma Rogers Dr Louise Reynard Dr Kenneth Rankin Professor John Loughlin
| Functional Investigation of an OA susceptibility locus at chromsome 9q33.1 associated with female hip osteoarthritis | 2016 |
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Dr Arthur Pratt Dr Amy Anderson Julie Diboll Andrew Skelton Dr Dennis Lendrem et al. | Identification of novel expression quantitative trait loci in CD4+ T cells of untreated early arthritis patients | 2016 |
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Dr Louise Reynard Professor John Loughlin
| Investigating the effects of high-glucose exposure on DNA methylation and gene transcription in musculoskeletal cells | 2016 |
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Dr Fiona Gee Dr Michael Rushton Professor John Loughlin Dr Louise Reynard
| Correlation of the Osteoarthritis Susceptibility Variants That Map to Chromosome 20q13 With an Expression Quantitative Trait Locus Operating on NCOA3 and With Functional Variation at the Polymorphism rs116855380 | 2015 |
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Dr Michael Rushton Professor David Young Professor John Loughlin Dr Louise Reynard
| Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients | 2015 |
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Dr Michael Rushton Professor David Young Professor John Loughlin Dr Louise Reynard
| Differential DNA methylation and expression of inflammatory and zinc transporter genes defines sub-groups of osteoarthritic hip patients | 2015 |
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Dr Colin Shepherd Andrew Skelton Dr Michael Rushton Dr Louise Reynard Professor John Loughlin et al. | Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874 | 2015 |
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Dr Katherine Johnson Dr Louise Reynard Professor John Loughlin
| Functional characterisation of the osteoarthritis susceptibility locus at chromosome 6q14.1 marked by the polymorphism rs9350591 | 2015 |
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Dr Michael Rushton Dr Louise Reynard Professor David Young Dr Colin Shepherd Dr Rebecca Darlay et al. | Methylation of cartilage DNA is a mediator of genetic risk at several OA susceptibility loci | 2015 |
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Dr Michael Rushton Dr Louise Reynard Professor David Young Dr Colin Shepherd Dr Fiona Gee et al. | Methylation quantitative trait locus (meQTL) analysis of osteoarthritis links epigenetics with genetic risk | 2015 |
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Professor John Loughlin Dr Louise Reynard
| Osteoarthritis: Epigenetics of articular cartilage in knee and hip OA | 2015 |
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Professor John Loughlin Dr Louise Reynard
| Osteoarthritis: Epigenetics of articular cartilage in knee and hip OA | 2015 |
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Dr Louise Reynard Professor John Loughlin
| The carbohydrate sulfotransferase gene CHST11 is regulated by DNA methylation which impacts on the functional effect of the OA generic susceptibility residing at this locus | 2015 |
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Emma Rogers Dr Louise Reynard Professor John Loughlin
| The role of inflammation-related genes in osteoarthritis | 2015 |
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Dr Fiona Gee Clare Clubbs Dr Emma Raine Dr Louise Reynard Professor John Loughlin et al. | Allelic expression analysis of genes from within the osteoarthritis susceptibility locus at chromosome 3p21 reveals functional gene expression effects at GNL3 and SPCS1 that correlate with the association signal | 2014 |
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Dr Fiona Gee Clare Clubbs Emma Raine Dr Louise Reynard Professor John Loughlin et al. | Allelic expression analysis of the osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3 and SPCS1 | 2014 |
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Dr Fiona Gee Clare Clubbs Dr Emma Raine Dr Louise Reynard Professor John Loughlin et al. | Allelic expression analysis of the osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3 and SPCS1 | 2014 |
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Dr Michael Rushton Dr Louise Reynard Dr Matthew Barter Dr Kenneth Rankin Professor David Young et al. | Characterisation of the cartilage DNA methylome in knee and hip osteoarthritis using high-density genome-wide analysis | 2014 |
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Dr Michael Rushton Dr Louise Reynard Dr Matthew Barter Ramsay Refaie Dr Kenneth Rankin et al. | Characterization of the cartilage DNA methylome in knee and hip osteoarthritis | 2014 |
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Dr Louise Reynard Dr Catherine Bui Catherine Syddall Professor John Loughlin
| CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis susceptibility SNP rs143383 | 2014 |
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Dr David McDonald Dr Bernadette Carroll Nicholas Robertson Dr Helen Griffin Professor Jeremy Lakey et al. | Dual Proteolytic Pathways Govern Glycolysis and Immune Competence | 2014 |
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Emma Rogers Dr Louise Reynard Dr Kate Rennie Professor John Loughlin
| Expression analysis of osteoarthritis associated genes in mesenchymal stem cells differentiating into joint-associated cells | 2014 |
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Dr Katherine Johnson Dr Louise Reynard Professor John Loughlin
| Functional analysis of the osteoarthritis susceptibility locus marked by the polymorphism rs10492367 | 2014 |
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Dr Louise Reynard Dr Madhushika Ratnayake Dr Mauro Santibanez Koref Professor John Loughlin
| Functional analysis of the osteoarthritis susceptibility locus residing at the carbohydrate sulfotransferase 11 gene CHST11 | 2014 |
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Emma Raine Dr Louise Reynard Professor John Loughlin
| Identification and analysis of a SMAD3 cis-acting eQTL operating in primary osteoarthritis and in the aneurysms and osteoarthritis syndrome | 2014 |
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Dr Emma Raine Dr Louise Reynard Professor John Loughlin
| Identification and analysis of a SMAD3 cis-acting eQTL operating in primary osteoarthritis and in the aneurysms and osteoarthritis syndrome | 2014 |
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Dr Michael Rushton Dr Fiona Gee Dr Louise Reynard Professor John Loughlin
| The osteoarthritis association marked by SNP rs6094710 mediates its effect by reducing the expression of NCOA3 in joint tissues | 2014 |
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Dr Emma Raine Andrew Dodd Dr Louise Reynard Professor John Loughlin
| Allelic expression analysis of the osteoarthritis susceptibility gene COL11A1 in human joint tissues | 2013 |
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Dr Louise Reynard Professor John Loughlin
| Insights from human genetic studies into the pathways involved in osteoarthritis | 2013 |
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Dr Louise Reynard Professor John Loughlin
| The genetics and functional analysis of primary osteoarthritis susceptibility | 2013 |
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Catherine Syddall Dr Louise Reynard Professor David Young Professor John Loughlin
| The Identification of Trans-acting Factors That Regulate the Expression of GDF5 via the Osteoarthritis Susceptibility SNP rs143383 | 2013 |
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Andrew Dodd Dr Emma Raine Dr Louise Reynard Professor John Loughlin
| Allelic expression analysis in patient issues of the osteoarthritis and of the lumbar disc herniation susceptibility loci that map to COL11A1 | 2012 |
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Dr Madhushika Ratnayake Dr Louise Reynard Dr Emma Raine Dr Mauro Santibanez Koref Professor John Loughlin et al. | Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3 | 2012 |
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Dr Madhushika Ratnayake Dr Louise Reynard Dr Emma Raine Dr Mauro Santibanez Koref Professor John Loughlin et al. | Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3 | 2012 |
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Dr Madhushika Ratnayake Dr Louise Reynard Emma Raine Dr Mauro Santibanez Koref Professor John Loughlin et al. | Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3 | 2012 |
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Dr Emma Raine Dr Louise Reynard Professor John Loughlin
| Allelic expression analysis, and association with OA, of common variants in SMAD3 | 2012 |
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Professor Sophie Hambleton Dr David McDonald Dr Helen Griffin Angela Grainger Dr Louise Reynard et al. | Autosomal recessive combines immunodeficiency due to loss of function mutation in Tripeptidyl Peptidase II | 2012 |
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Dr Catherine Bui Dr Matthew Barter Jenny Scott Dr Martin Galler Dr Louise Reynard et al. | cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis | 2012 |
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Professor Matthew Collin Dr Rachel Dickinson Professor Muzlifah Haniffa Dr Naomi McGovern Dr Helen Griffin et al. | Evolution of Dendritic Cell, Monocyte B and NK Lymphoid (DCML) deficiency; a human primary immunodeficiency arising from GATA-2 mutation | 2012 |
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Dr Louise Reynard Professor John Loughlin
| Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q22 | 2012 |
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Dr Emma Raine Andrew Dodd Dr Louise Reynard Professor John Loughlin
| Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q22 | 2012 |
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Dr Louise Reynard Professor John Loughlin
| Genetics and epigenetics of osteoarthritis | 2012 |
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Catherine Syddall Dr Louise Reynard Professor David Young Professor John Loughlin
| The identification of the trans-acting factors that differentially regulate the expression of GDF5 via the OA associated SNP rs143383 | 2012 |
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Catherine Syddall Dr Louise Reynard Professor David Young Professor John Loughlin
| The identification of trans-acting factors that differentially regulate the expression of GDF5 via the osteoarthritis associated SNP RS143383 | 2012 |
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Dr Louise Reynard Catherine Syddall Professor John Loughlin
| The osteoarthritis susceptibility gene GDF5 is under epigenetic regulation by DNA methylation - the molecular interplay between genetics and epigenetics in disease risk | 2012 |
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Dr Helen Griffin Dr David McDonald Dr Rachel Dickinson Angela Grainger Dr Louise Reynard et al. | Whole exome sequencing as a diagnostic tool in primary immunodeficiency | 2012 |
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Andrew Dodd Dr Louise Reynard Professor John Loughlin
| Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus | 2011 |
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Dr Rachel Dickinson Dr Helen Griffin Dr Venetia Bigley Dr Louise Reynard Raf Hussain et al. | Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency | 2011 |
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Dr Louise Reynard Dr Catherine Bui Professor David Young Professor John Loughlin
| Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation | 2011 |
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Dr David McDonald Dr Helen Griffin Angela Grainger Dr Louise Reynard Professor John Loughlin et al. | Whole-exome deep sequencing identifies a novel causative mutation in primary immunodeficiency | 2011 |
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Dr Louise Reynard Athanasia Gravani Professor John Loughlin
| The osteoarthritis-associated gene GDF5 is under epigenetic regulation in patient tissues and in a range of human cell lines | 2010 |
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Dr Louise Reynard
| Increased sex chromosome expression and epigenetic abnormalities in spermatids from male mice with Y chromosome deletions. | 2009 |
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Dr Louise Reynard
| The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein | 2009 |
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Dr Louise Reynard
| Expression analysis of the mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr), reveals that Xmr encodes a spermatid-expressed cytoplasmic protein, SLX/XMR | 2007 |
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