Publications by Dr Paul Sinclair - ePrints

Browsing publications by Dr Paul Sinclair.

Newcastle Authors	Title	Year
Dr Paul Sinclair Dr Ruth Cranston Prahlad Raninga Joanna Cheng Rebecca Hanna et al.	Disruption to the FOXO-PRDM1 axis resulting from deletions of chromosome 6 in acute lymphoblastic leukaemia	2023
Sarra Ryan Dr Ruth Cranston Claire Schwab Dr Matthew Bashton Dr Paul Sinclair et al.	The genomic landscape of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21	2023
Dr Deepali Pal Dr Helen Blair Sean Hockney Dr Melanie Beckett Mankaran Singh et al.	hiPSC-derived bone marrow milieu identifies a clinically actionable driver of niche-mediated treatment resistance in leukemia	2022
Emeritus Professor Amritpal Hungin Dr Paul Sinclair	Knowledge gaps in the management of refractory reflux-like symptoms: Healthcare provider survey	2022
Dr Paul Sinclair Dr Sarra Ryan Dr Matthew Bashton Shaun Hollern Rebecca Hanna et al.	SH2B3 inactivation through CN-LOH-12q is uniquely associated with B-cell precursor ALL with iAMP21 or other chromosome 21 gain	2019
Dr Ruth Cranston Dr Paul Sinclair Dr Matthew Bashton Dr Matthew Selby Professor Christine Harrison FRCPath FMedSci et al.	A Genome-Wide CRISPR Screen Implicates MYC Dysregulation in TCF3-PBX1 B-ALL	2018
Dr Paul Sinclair Dr Helen Blair Dr Sarra Ryan Dr Lars Buechler Joanna Cheng et al.	Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21	2018
Zach Dixon Dr Lindsay Nicholson Elizabeth Matheson Dr Paul Sinclair Professor Christine Harrison FRCPath FMedSci et al.	CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response	2017
Dr Alex Elder Dr Klaus Rehe Dr Simon Bomken Dr Paul Sinclair Katie Dormon et al.	The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts.	2016
Dr Sarra Ryan Elizabeth Matheson Dr Paul Sinclair Dr Matthew Bashton Claire Schwab et al.	The role of the RAS pathway in iAMP21-ALL	2016
Dr Paul Sinclair Joanna Cheng Prahlad Raninga Rebecca Hanna Shaun Hollern et al.	A Targeted Functional Clone Tracking Assay for the Identification of Tumour Suppressor Genes in BCP- ALL Implicates the Transcription Factors FOXO3 and PRDM1	2015
Dr Klaus Rehe Dr Simon Bomken Dr Paul Sinclair Dr Lisa Russell Professor Olaf Heidenreich et al.	Childhood pre-B acute lymphoblastic leukaemia cells capable of central nervous system engraftment are common, heterogeneous and transit the blood-cerebrospinal fluid barrier	2015
Dr Jeyanthy Eswaran Dr Paul Sinclair Professor Olaf Heidenreich Professor Julie Irving Dr Lisa Russell et al.	The pre-B-cell receptor checkpoint in acute lymphoblastic leukaemia	2015
Claire Schwab Sarra Ryan Professor Anthony Moorman Dr Richard McNally Professor Bryan Young et al.	Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia	2014
Dr Jeyanthy Eswaran Dr Paul Sinclair Dr Sirintra Nakjang Professor Christine Harrison FRCPath FMedSci	Identification of Cmtm Family Proteins As Tumor Suppressor and Membrane Regulator in B Cell Precursor Acute Lymphoblastic Leukemia	2014
Jake Clayton Joanna Cheng Dr Sarra Ryan Professor Christine Harrison FRCPath FMedSci Dr Paul Sinclair et al.	Oncogenomic Screening Strategies to Identify Tumour Suppressor Genes on Chromosome 12 in Acute Myeloid Leukaemia	2014
Dr Paul Sinclair Dr Vikki Rand Hannah Ensor Professor Christine Harrison FRCPath FMedSci	Analysis of a breakpoint cluster reveals insight into the mechanism of intrachromosomal amplification in a lymphoid malignancy	2011
Dr Vikki Rand Dr Lisa Russell Claire Schwab Hannah Ensor Professor Julie Irving et al.	Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia	2011
Dr Paul Sinclair	Dynamic plasticity of large -scale chromatin structure revealed by self-assembly of engineered chromosome regions	2010
Dr Paul Sinclair	Insights into interphase large-scale chromatin structure from analysis of engineered chromosome regions	2010
Dr Vikki Rand Dr Lisa Russell Professor Julie Irving Lisa Jones Dr Dino Masic et al.	What Is the Initiating Mechanism of iAMP21 in Childhood B Cell Precursor ALL?	2009
Dr Paul Sinclair	The facultative heterochromatin of the inactive X chromosome has a distinctive condensed ultrastructure	2008
Dr Paul Sinclair Professor Christine Harrison FRCPath FMedSci	Analysis of balanced rearrangements of chromosome 6 in acute leukemia: clustered breakpoints in q22-q23 and possible involvement of c-MYB in a new recurrent translocation, t(6;7)(q23;q32 through 36)	2005
Dr Paul Sinclair Professor Christine Harrison FRCPath FMedSci	A fluorescence in situ hybridization map of 6q deletions in acute lymphocytic leukemia: identification and analysis of a candidate tumor suppressor gene	2004
Dr Paul Sinclair Dr Bridget Wilkins	Identification of four new translocations involving FGFR1 in myeloid disorders	2001
Dr Paul Sinclair	Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene	2001
Dr Paul Sinclair Professor Christine Harrison FRCPath FMedSci	Deletion of 6q16-q21 in human lymphoid maligancies: a mapping and deletion analysis	2000
Dr Paul Sinclair	Large deletions at the t(9;22) breakpoint are common and may define a poor-prognosis subgroup of patients with chronicmyeloid leukemia	2000
Dr Paul Sinclair	Comparative analysis of G-banding, chromosome painting, locus specific FISH and CGH in chronic myeloid leukemia blast chrisis	1999
Dr Paul Sinclair	Achievement of complete cytogenetic remission after two very low-dose doner leucocyte infusions in a patient with extensive cGVHD relapsing in accelerated phase post allogeneic BMT for CML	1998
Dr Paul Sinclair	Improved sensitivity of BCR-ABL detection: a triple-probe three colour fluorescence in situ hybridisation system.	1997
Dr Paul Sinclair	t(9;13)(q34;q12) chromosomal translocation persisting 4 years post autologous bone marrow transplantation for secondary AML despite morphological remission	1996
Dr Paul Sinclair	Denovo ring chromosome 3: a new case with a mild phenotype	1991