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Observation of anomalous diffusion in excised tissue by characterizing the diffusion-time dependence of the MR signal

Lookup NU author(s): Professor Peter Thelwall

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Abstract

This report introduces a novel method to characterize the diffusion-time dependence of the diffusion-weighted magnetic resonance (MR) signal in biological tissues. The approach utilizes the theory of diffusion in disordered media where two parameters, the random walk dimension and the spectral dimension, describe the evolution of the average propagators obtained from q-space MR experiments. These parameters were estimated, using several schemes, on diffusion MR spectroscopy data obtained from human red blood cell ghosts and nervous tissue autopsy samples. The experiments demonstrated that water diffusion in human tissue is anomalous, where the mean-square displacements vary slower than linearly with diffusion time. These observations are consistent with a fractal microstructure for human tissues. Differences observed between healthy human nervous tissue and glioblastoma samples suggest that the proposed methodology may provide a novel, clinically useful form of diffusion MR contrast. (c) 2006 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Ozarslan E, Basser PJ, Shepherd TM, Thelwall PE, Vemuri BC, Blackband SJ

Publication type: Article

Publication status: Published

Journal: Journal of Magnetic Resonance

Year: 2006

Volume: 183

Issue: 2

Pages: 315-323

ISSN (print): 1090-7807

ISSN (electronic): 1096-0856

Publisher: Academic Press

URL: http://dx.doi.org/10.1016/j.jmr.2006.08.009

DOI: 10.1016/j.jmr.2006.08.009

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