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Clostridial neurotoxins

Lookup NU author(s): Dr Ajith Goonetilleke, Emeritus Professor John Harris

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Abstract

The genus Clostridium comprises a number of spore forming Gram positive, rod shaped bacilli. They are found in the intestines of numerous mammalian species including domestic animals, horses, chickens, and humans. They are also widely distributed in the soil and in marine and freshwater sediments. Many clostridial species produce medically important toxins but the species of neurological interest (Clostridium tetani and Clostridium botulinum) produce neurotoxins. The toxins responsible for these neurotoxic syndromes are tetanus toxin (sometimes known as tetanospasmin) and the botulinum toxins.

Publication metadata

Author(s): Goonetilleke A, Harris JB

Publication type: Article

Publication status: Published

Journal: Journal of Neurology, Neurosurgery and Psychiatry

Year: 2004

Volume: 75

Issue: Suppl. 3

Pages: iii35-iii39

ISSN (print): 0022-3050

ISSN (electronic): 1468-330X

Publisher: BMJ Publishing Group

URL: http://dx.doi.org/10.1136/jnnp.2004.046102

DOI: 10.1136/jnnp.2004.046102

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