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Endoglin expression in early development is associated with vasculogenesis and angiogenesis

Lookup NU author(s): Dr Leon Jonker, Professor Helen ArthurORCiD

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Abstract

Endoglin is an auxiliary receptor for the transforming growth factor-beta family of cytokines and is required for angiogenesis and heart development. Endoglin expression during mouse embryogenesis was analysed by monitoring beta-galactosidase expression from a lacZ reporter cassette inserted downstream of the endoglin promoter. Expression was first detected at 6.5 days post-coitum (dpc) in the amniotic fold and developing allantois. Between 7.5 and 8.5 dpc, endoglin was expressed in endothelial cells of the yolk sac, dorsal aorta and primitive heart tube, and from 9.5 to 13.5 dpc in endothelial cells throughout the developing vasculature. Interestingly, this pattern of endoglin expression is almost identical to that reported for Alk1. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Jonker L; Arthur HM

Publication type: Article

Publication status: Published

Journal: Mechanisms of Development

Year: 2002

Volume: 110

Issue: 1-2

Pages: 193-196

ISSN (print): 0925-4773

ISSN (electronic): 1872-6356

Publisher: Elsevier Ireland Ltd

URL: http://dx.doi.org/10.1016/S0925-4773(01)00562-7

DOI: 10.1016/S0925-4773(01)00562-7

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