Browse by author
Lookup NU author(s): Professor Gareth Veal, Julie Errington, Dr Chris RedfernORCiD, Professor Andrew Pearson, Professor Alan Boddy
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Vascular endothelial growth factor-C (VEGF-C) has been implicated in lymphangiogenesis, the process of new lymphatics formation. The present study investigated VEGF-C mRNA expression in invasive cervical cancer tissue. Additionally, the association of VEGF-C mRNA with clinicopathological features was examined. VEGF-C mRNA expression was assessed by reverse transcription-polymerase chain reaction using -action as an internal control. 75 patients presenting with invasive cervical cancer were included in the trial. VEGF-C mRNA expression was markedly higher in tumours in which pelvic lymph node metastasis was diagnosed by magnetic resonance (MR) imaging (P = 0.002). 53 patients displaying stage Ib–IIb cervical cancer underwent radical hysterectomy and pelvic lymphadenectomy. VEGF-C expression was significantly higher in tumours exhibiting deep stromal invasion, pelvic lymph node metastasis and lymph-vascular space involvement (P = 0.016, P = 0.006 and P = 0.036, respectively). Multivariate analysis revealed VEGF-C mRNA expression to be the sole independent factor influencing pelvic lymph node metastasis. Subjects demonstrating VEGF-C mRNA expression displayed significantly poorer prognoses than those lacking VEGF-C mRNA expression (P = 0.049). These findings provide evidence supporting the involvement of VEGF-C expression in the promotion of lymph node metastasis in cervical cancer. Furthermore, examination of VEGF-C expression in biopsy specimens may be beneficial in the prediction of pelvic lymph node metastasis.
Author(s): Veal, G. J., Errington, J., Redfern, C. P. F., Pearson, A. D. J., Boddy, A. V.
Publication type: Article
Publication status: Published
Journal: British Journal of Cancer
Year: 2001
Volume: 85
Issue: 1
Pages: 93-97
ISSN (print): 0007-0920
ISSN (electronic): 1532-1827
URL: http://dx.doi.org/10.1054/bjoc.2001.1846
DOI: 10.1054/bjoc.2001.1846
Notes: Original format: conference proceeding.
Altmetrics provided by Altmetric
