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Lookup NU author(s): Dr Julian Thomas
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DNA motifs at several informative loci in more than 500 strains of Helicobacter pylori from five continents were studied by PCR and sequencing to gain insights into the evolution of this gastric pathogen. Five types of deletion, insertion, and substitution motifs were found at the right end of the H. pylori cag pathogenicity island. Of the three most common motifs, type I predominated in Spaniards, native Peruvians, and Guatemalan Ladinos (mixed Amerindian-European ancestry) and also in native Africans and U.S. residents; type II predominated among Japanese and Chinese; and type III predominated in Indians from Calcutta. Sequences in the cagA gene and in vacAm1 type alleles of the vacuolating cytotoxin gene (vacA) of strains from native Peruvians were also more like those from Spaniards than those from Asians. These indications of relatedness of Latin American and Spanish strains, despite the closer genetic relatedness of Amerindian and Asian people themselves, lead us to suggest that H. pylori may have been brought to the New World by European conquerors and colonists about. 500 years ago. This thinking, in turn, suggests that H. pylori infection might have become widespread in people quite recently in human evolution.
Author(s): Thomas JE; Kersulyte D; Mukhopadhyay AK; Velapatino B; Su WW; Pan ZJ; Garcia C; Hernandez V; Valdez Y; Mistry RS; Gilman RH; Yuan Y; Gao H; Alarcon T; Lopez-Brea M; Nair GB; Chowdhury A; Datta S; Shirai M; Nakazawa T; Ally R; Segal I; Wong BCY; Lam SK; Olfat FO; Boren T; Engstrand L; Torres O; Schneider R; Czinn S; Berg DE
Publication type: Article
Publication status: Published
Journal: Journal of Bacteriology
Year: 2000
Volume: 182
Issue: 11
Pages: 3210-3218
ISSN (print): 0021-9193
ISSN (electronic): 1098-5530
Publisher: American Society for Microbiology
URL: http://dx.doi.org/10.1128/JB.182.11.3210-3218.2000
DOI: 10.1128/JB.182.11.3210-3218.2000
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