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Transfusion-related alloimmune neutropenia: an undescribed complication of blood transfusion

Lookup NU author(s): Dr Jonathan Wallis

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Abstract

Alloimmune neutropenia in neonates is rare. We describe severe and persistent neutropenia in a 4-week-old neonate, which arose within 2 h of a transfusion of blood that contained about 28 mL of plasma and in which strong antibodies against human neutrophil antigen 1b (HNA-1b) were subsequently identified. The infant was positive for HNA-1b. No other likely cause of neutropenia was discovered. We believe this complication of blood transfusion to be a previously unrecognised one, and have called the condition transfusion-related alloimmune neutropenia (TRAIN).


Publication metadata

Author(s): Wallis JP, Haynes S, Stark G, Green FA, Lucas GF, Chapman CE

Publication type: Article

Publication status: Published

Journal: Lancet

Year: 2002

Volume: 360

Issue: 9339

Pages: 1073-1074

ISSN (print): 0140-6736

ISSN (electronic): 1474-547X

Publisher: The Lancet Publishing Group

URL: http://dx.doi.org/10.1016/S0140-6736(02)11132-9

DOI: 10.1016/S0140-6736(02)11132-9


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