Browse by author
Lookup NU author(s): Paula Nielsen, Klaas Stephan
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Altered connections between the thalamus and the prefrontal cortex are often implicated in theories concerning the pathogenesis of schizophrenia. Using a model based on anatomically realistic connection patterns between thalamus and prefrontal cortex, we analyzed changes of prefrontal activity resulting from stimulation of the mediodorsal thalamus. Here we demonstrate that the specific influence of thalamo-cortical projections is smaller than the importance of intra-prefrontal connectivity in shaping prefrontal activity patterns. These results might be helpful in explaining experimentally observed hypo- and hyperactive states of prefrontal cortex in schizophrenic patients, (C) 2002 Elsevier Science B.V. All rights reserved.
Author(s): Kamper L, Bozkurt A, Nielsen P, Dyhrfjeld-Johnsen J, Stephan KE, Kotter R
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: Neurocomputing: 10th Computational Neuroscience Meeting (CSN 01)
Year of Conference: 2002
Pages: 869-873
ISSN: 0925-2312
Publisher: Elsevier BV
URL: http://dx.doi.org/10.1016/S0925-2312(02)00485-X
DOI: 10.1016/S0925-2312(02)00485-X
Library holdings: Search Newcastle University Library for this item
ISBN: 18728286
