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Lookup NU author(s): Dr Heiko Peters
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The epithelial thymic anlage develops from the third pharyngeal pouch. Pax9 is expressed in the entire pharyngeal endoderm, and its function is required for normal development of organs derived from pharyngeal pouches. Here, we show that in Pax9 null mice, the thymic anlage develops as an ectopic polyp-like structure in the larynx. It expresses Whn/Foxn1, a marker of thymic epithelium, but fails to perform the normal caudo-ventral movement to the upper mediastinum. The thymic rudiment contains mesenchymal cells, blood vessels and is colonized by T cell progenitors. However, from embryonic day 14.5 onwards, the size of the Pax9 mutant thymus is severely reduced. Whereas expression of TCRbeta chain genes is readily detectable in the mutant thymus, no expression of the TCRgamma chain was detectable. Our results identify a new genetically defined control point of thymopoiesis.
Author(s): Peters H; Hetzer-Egger C; Schorpp M; Haas-Assenbaum A; Balling R; Boehm T
Publication type: Article
Publication status: Published
Journal: European Journal of Immunology
Year: 2002
Volume: 32
Issue: 4
Pages: 1175-1181
ISSN (print): 0014-2980
ISSN (electronic): 1521-4141
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
URL: http://dx.doi.org/10.1002/1521-4141(200204)32:4<1175::AID-IMMU1175>3.0.CO;2-U
DOI: 10.1002/1521-4141(200204)32:4<1175::AID-IMMU1175>3.0.CO;2-U
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