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Lookup NU author(s): Pawel Znojek
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Zinc exhibits antidepressant-like activity in preclinical tests (the forced swim test and tail suspension test) and in olfactory bulbectomy and chronic unpredictable stress; two models of depression. Zinc also enhances the treatment of depression in humans. In the present study we evaluated the antidepressant activity of zinc in another model of depression-chronic mild stress (CMS) and the effect of zinc treatment on BDNF protein and the mRNA level. In CMS zinc hydroaspartate (10 mg/kg) exhibited a rapid (after 1 week of treatment) antidepressant-like effect. Chronic treatment with zinc induced a 17-39% increase in the BDNF mRNA and protein level in the hippocampus. These data indicate a rapidly acting antidepressant-like activity of zinc in CMS and the involvement of zinc in the regulation of BDNF. © 2008 Springer-Verlag.
Author(s): Sowa-Kucma M, Legutko B, Szewczyk B, Novak K, Znojek P, Poleszak E, Papp M, Pilc A, Nowak G
Publication type: Article
Publication status: Published
Journal: Journal of Neural Transmission
Year: 2008
Volume: 115
Issue: 12
Pages: 1621-1628
ISSN (print): 0300-9564
ISSN (electronic): 1435-1463
Publisher: Springer Wien
URL: http://dx.doi.org/10.1007/s00702-008-0115-7
DOI: 10.1007/s00702-008-0115-7
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