Browse by author
Lookup NU author(s): Professor Bobby McFarlandORCiD, Professor Gavin Hudson, Professor Robert Taylor, Dr Stephen Hodges, Professor Patrick Chinnery, Dr Vankateswara Ramesh
We report the case of a 2-year-old boy with seizures who developed hepatic failure shortly after commencing sodium valproate. Unexpectedly, liver function returned to normal on stopping the drug. Sequencing of the mitochondrial polymerase γ gene (POLG1) revealed four heterozygous substitutions, two of which have been identified in cases of Alpers-Huttenlocher disease.
Author(s): McFarland R, Hudson G, Taylor RW, Green SH, Hodges S, McKiernan PJ, Chinnery PF, Ramesh V
Publication type: Article
Publication status: Published
Journal: Archives of Disease in Childhood
Year: 2008
Volume: 93
Issue: 2
Pages: 151-153
Date deposited: 08/06/2010
ISSN (print): 0003-9888
ISSN (electronic): 1468-2044
Publisher: BMJ Group
URL: http://dx.doi.org/10.1136/adc.2007.122911
DOI: 10.1136/adc.2007.122911
PubMed id: 18208989
Altmetrics provided by Altmetric