Browse by author
Lookup NU author(s): Professor Heather Cordell
The case/pseudocontrol method provides a convenient framework for family-based association analysis of case-parent trios, incorporating several previously proposed methods such as the transmission/disequilibrium test and log-linear modelling of parent-of-origin effects. The method allows genotype and haplotype analysis at an arbitrary number of linked and unlinked multiallelic loci, as well as modelling of more complex effects such as epistasis, parent-of-origin effects, maternal genotype and mother-child interaction effects, and gene-environment interactions. Here we extend the method for analysis of quantitative as opposed to dichotomous (e.g. disease) traits. The resulting method can be thought of as a retrospective approach, modelling genotype given trait value, in contrast to prospective approaches that model trait given genotype. Through simulations and analytical derivations, we examine the power and properties of our proposed approach, and compare it to several previously proposed single-locus methods for quantitative trait association analysis. We investigate the performance of the different methods when extended to allow analysis of haplotype, maternal genotype and parent-of-origin effects. With randomly ascertained families, with or without population stratification, the prospective approach (modeling trait value given genotype) is found to be generally most effective, although the retrospective approach has some advantages with regard to estimation and interpretability of parameter estimates when applied to selected samples. © 2007 Wiley-Liss, Inc.
Author(s): Wheeler E, Cordell HJ
Publication type: Article
Publication status: Published
Journal: Genetic Epidemiology
Year: 2007
Volume: 31
Issue: 8
Pages: 813-833
Print publication date: 01/12/2007
ISSN (print): 0741-0395
ISSN (electronic): 1098-2272
Publisher: John Wiley & Sons, Inc.
URL: http://dx.doi.org/10.1002/gepi.20243
DOI: 10.1002/gepi.20243
PubMed id: 17549757
Altmetrics provided by Altmetric