Do mitochondrial DNA mutations have a role in neurodegenerative disease?

Krishnan, KJ; Reeve, AK; Turnbull, DM

doi:10.1042/BST0351232

Do mitochondrial DNA mutations have a role in neurodegenerative disease?

Lookup NU author(s): Dr Amy Reeve, Emeritus Professor Doug Turnbull

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Abstract

A decline in mitochondrial function has long been shown to exist in neurodegenerative disease. Whether this decline is a secondary consequence of other factors or whether it causes the eventual death of a cell is unknown. In this review, we will discuss some of the major evidence surrounding mitochondrial DNA mutations leading to mitochondrial dysfunction in neurodegenerative disease and discuss their possible role in neurodegeneration. ©The Authors.