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Lookup NU author(s): Dr Michael FirbankORCiD, Dr Emma Burton, Dr Robert Barber, Dr Sally Stephens, Professor Rose Anne Kenny, Dr Clive Ballard, Professor Raj KalariaORCiD, Professor John O'Brien
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Stroke is an important risk factor for dementia, but the exact mechanisms involved in cognitive decline remain unclear. In this study, we related baseline MRI brain measures with later cognitive decline. Seventy-nine stroke survivors aged 75+ years without dementia were recruited 3-month post-stroke. They underwent yearly neuropsychological assessments and had an MRI at baseline and 2 years. Medial temporal lobe atrophy (MTA) was scored and volume of white matter hyperintensities (WMH) was measured at baseline. The rate of ventricular enlargement was measured by comparing the baseline and repeat images. Linear regression indicated that memory loss was related to both baseline memory and MTA (p = 0.001; standardized regression coefficient β = -0.35) but not WMH volume. The only independent predictor of ventricular enlargement was MTA (p = 0.003; β = 0.47). However, no baseline MRI variable differed between those who did (18%) and did not (82%) develop dementia. The association of MTA but not WMH with subsequent cognitive decline and increasing brain atrophy suggests a greater role for Alzheimer type than vascular pathology in delayed cognitive impairment after stroke. © 2006 Elsevier Inc. All rights reserved.
Author(s): Firbank MJ, Burton EJ, Barber R, Stephens S, Kenny RA, Ballard C, Kalaria RN, O'Brien JT
Publication type: Article
Publication status: Published
Journal: Neurobiology of Aging
Year: 2007
Volume: 28
Issue: 11
Pages: 1664-1669
Print publication date: 01/11/2007
ISSN (print): 0197-4580
ISSN (electronic): 1558-1497
Publisher: Elsevier
URL: http://dx.doi.org/10.1016/j.neurobiolaging.2006.07.009
DOI: 10.1016/j.neurobiolaging.2006.07.009
PubMed id: 16934370
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