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Therapeutic potential of drugs to modulate DNA repair in cancer

Lookup NU author(s): Professor Nicola CurtinORCiD

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Abstract

Most established cancer therapy regimes involve DNA-damaging chemotherapy or radiotherapy. The DNA repair capacity of the tumour, therefore, represents a mechanism of therapeutic resistance. Drugs to inhibit DNA repair pathways have been developed and they demonstrate good chemosensitisation and radiosensitisation activity in preclinical models. Two classes of DNA repair inhibitors have entered clinical trial and show promising activity. Genetic instability in tumours may be at least partially due to defects in DNA repair pathways, such defects may underlie the inherent sensitivity of some tumours to certain classes of anticancer agent. DNA repair defects may also make the tumour dependent on complimentary or back-up pathways; laboratory evidence shows that targeting these complimentary pathways results in tumour-selective therapy. © 2007 Informa UK Ltd.

Publication metadata

Author(s): Curtin NJ

Publication type: Review

Publication status: Published

Journal: Expert Opinion on Therapeutic Targets

Year: 2007

Volume: 11

Issue: 6

Pages: 783-799

Print publication date: 01/06/2007

ISSN (print): 1472-8222

ISSN (electronic): 1744-7631

URL: http://dx.doi.org/10.1517/14728222.11.6.783

DOI: 10.1517/14728222.11.6.783

PubMed id: 17504016

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