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Lookup NU author(s): Dr Christopher Morris, Geoffrey Taylor, Dr Amy Reeve, Emeritus Professor Robert Perry, Dr Evelyn Jaros, Professor Robert Taylor, Emeritus Professor Doug Turnbull
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Here we show that in substantia nigra neurons from both aged controls and individuals with Parkinson disease, there is a high level of deleted mitochondrial DNA (mtDNA) (controls, 43.3% ± 9.3%; individuals with Parkinson disease, 52.3% ± 9.3%). These mtDNA mutations are somatic, with different clonally expanded deletions in individual cells, and high levels of these mutations are associated with respiratory chain deficiency. Our studies suggest that somatic mtDNA deletions are important in the selective neuronal loss observed in brain aging and in Parkinson disease. © 2006 Nature Publishing Group.
Author(s): Bender A, Krishnan KJ, Morris CM, Taylor GA, Reeve AK, Perry RH, Jaros E, Hersheson JS, Betts J, Klopstock T, Taylor RW, Turnbull DM
Publication type: Article
Publication status: Published
Journal: Nature Genetics
Year: 2006
Volume: 38
Issue: 5
Pages: 515-517
ISSN (print): 1061-4036
ISSN (electronic): 1546-1718
Publisher: Nature Publishing Group
URL: http://dx.doi.org/10.1038/ng1769
DOI: 10.1038/ng1769
PubMed id: 16604074
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