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Cardiovascular risk in patients with end-stage renal disease: A potential role for advanced glycation end products

Lookup NU author(s): Emerita Professor Sally Marshall, Dr Michael Thompson, Dr Nicholas Hoenich

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Abstract

Cardiovascular complications are a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). Advanced glycation end products (AGE) are elevated in the plasma of such patients and are also found in atherosclerotic plaques. The cellular signalling pathway(s) underlying AGE-induced platelet aggregation have not been elucidated. One pathway currently receiving increased attention is the externalization of the membrane phospholipid, phosphatidylserine (PS), which plays an important role in the activation of clotting factors. In this study, we have investigated ex vivo a possible link between elevated AGE concentration and PS externalization. We observed (i) increased PS externalization in platelets from patients with ESRD, (ii) reconstitution of healthy platelets with serum from patients with ESRD resulted in increased PS externalization and (iii) incubation of platelets with purified human serum albumin (HSA)-AGE elicited PS externalization suggesting a role for AGE. Copyright © 2005 S. Karger AG.

Publication metadata

Author(s): Wang Y, Marshall SM, Thompson MG, Hoenich NA

Publication type: Article

Publication status: Published

Journal: Contributions to Nephrology

Year: 2005

Volume: 149

Pages: 168-174

Print publication date: 01/01/2005

ISSN (print): 0302-5144

ISSN (electronic): 1662-2782

Publisher: Karger

URL: http://dx.doi.org/10.1159/000085483

DOI: 10.1159/000085483

PubMed id: 15876841

Notes: Ronco C; Brendolan A; Levin NW (eds): Cardiovascular Disorders in Hemodialysis

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