Toggle Main Menu Toggle Search

Open Access padlockePrints

Genetic polymorphism of manganese superoxide dismutase (MnSOD) and breast cancer susceptibility

Lookup NU author(s): Emerita Professor Suzanne Cholerton, Professor Ann DalyORCiD

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Within mitochondria, manganese superoxide dismutase (MnSOD) provides a major defence against oxidative damage by reactive oxygen species (ROS). An alanine-9valine (Ala-9Val) polymorphism in the mitochondrial targeting sequence of MnSOD has been described and has recently been associated with risk of human breast cancer. Our present case-control study was performed to explore the association between MnSOD genetic polymorphism and individual susceptibility to breast cancer. Ala-9Val polymorphism in the signal sequence of the protein for MnSOD was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay in a study population. There was no significant difference in risk for breast cancer development between patients positive and negative for the MnSOD Ala allele with adjusted odds ratio (OR): 0.86 (95% confidence interval (CI) 0.43 to 1.72). When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catechol O-methyltransferase COMT-L (V158M) genotypes, the risk for developing breast cancer was significantly increased in patients with a body mass index (BMI) greater than 24 kg m-2 (OR: 1.42 (95%CI = 1.04-1.93)). Copyright © 2004 John Wiley & Sons, Ltd.


Publication metadata

Author(s): Kocabas NA, Sardas S, Cholerton S, Daly AK, Elhan AH, Karakaya AE

Publication type: Article

Publication status: Published

Journal: Cell Biochemistry and Function

Year: 2005

Volume: 23

Issue: 1

Pages: 73-76

ISSN (print): 0263-6484

ISSN (electronic): 1099-0844

Publisher: John Wiley & Sons Ltd.

URL: http://dx.doi.org/10.1002/cbf.1128

DOI: 10.1002/cbf.1128

PubMed id: 15386537


Altmetrics

Altmetrics provided by Altmetric


Share