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Lookup NU author(s): Dr Sergey Savelev, Dr Edward Okello, Emeritus Professor Elaine Perry
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Extracts of Salvia (sage) species have been reported to have cholinergic activities relevant to the treatment of Alzheimer's disease. A lack of information on the inhibition of the enzyme butyrylcholinesterase, also considered to be a target in the treatment of the disease, prompted this in vitro investigation of the essential oils of S. fruticosa, S. lavandulaefolia, S. officinalis and S. officinalis var. purpurea for anti-butyrylcholinesterase activity. Dose-dependent inhibition of human cholinesterases by the extracts and constituents was determined using the method of Ellman. A time dependent increase in the inhibition of butyrylcholinesterase by the oils of S. fruticosa and S. officinalis var. purpurea was evident. IC50 values decreased from 0.15 ± 0.007 and 0.14 ± 0.007 mg/mL after 5 min to 0.035 ± 0.016 and 0.06 ± 0.018 mg/mL after 90 min incubation time respectively. The slow onset of inhibition of butyrylcholinesterase was also shown by individual constituents, such as 3-carene and β-pinene. Analyses of the chemical composition of the oils and anti-butyrylcholinesterase activity of their constituents revealed that none of the compounds tested would account for the total activity of the oils and that synergy is likely. Copyright © 2004 John Wiley & Sons, Ltd.
Author(s): Savelev SU, Okello EJ, Perry EK
Publication type: Article
Publication status: Published
Journal: Phytotherapy Research
Year: 2004
Volume: 18
Issue: 4
Pages: 315-324
Print publication date: 01/04/2004
ISSN (print): 0951-418X
ISSN (electronic): 1099-1573
Publisher: John Wiley & Sons Ltd.
URL: http://dx.doi.org/10.1002/ptr.1451
DOI: 10.1002/ptr.1451
PubMed id: 15162368
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