Browse by author
Lookup NU author(s): Dr Stuart Bennett, Professor Mark Walker
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Aims: To determine the effects of rosiglitazone on insulin sensitivity, glucose tolerance and ambulatory blood pressure when administered to subjects with persistent impaired glucose tolerance (IGT). Methods: Eighteen subjects with persistent IGT were randomized to receive rosiglitazone 4 mg twice daily or matching placebo for 12 weeks. Evaluation at baseline and at the end of treatment included measurement of whole body insulin sensitivity during a euglycaemic hyperinsulinaemic clamp and deriving an insulin sensitivity index. Changes in glucose and insulin concentration were determined after oral glucose tolerance test (OGTT) and mixed meal tolerance tests, and 24-h ambulatory blood pressure was monitored. Results: Rosiglitazone significantly improved the insulin sensitivity index by 2.26 μg/kg per min per pmol/l relative to placebo (P = 0.0003). Four of nine subjects receiving rosiglitazone reverted to normal glucose tolerance and 5/9 remained IGT, although four of these had improved 2-h glucose values. In the placebo group, 1/9 subjects progressed to Type 2 diabetes and 8/9 remained IGT. Following OGTT and meal tolerance test, glucose and insulin area under curve were reduced over 3 and 4 h, respectively. Compared with placebo, ambulatory blood pressure decreased significantly in the rosiglitazone group by 10 mmHg systolic (P = 0.0066) and 8 mmHg diastolic (P = 0.0126). Conclusions: Consistent with its effects in patients with Type 2 diabetes, rosiglitazone substantially improved whole body insulin sensitivity and the glycaemic and insulinaemic responses to an OGTT and meal tolerance test in subjects with persistent IGT. Furthermore, rosiglitazone reduced systolic and diastolic ambulatory blood pressure in these subjects.
Author(s): Bennett SMA, Agrawal A, Elasha H, Heise M, Jones NP, Walker M, Wilding JPH
Publication type: Article
Publication status: Published
Journal: Diabetic Medicine
Year: 2004
Volume: 21
Issue: 5
Pages: 415-422
ISSN (print): 0742-3071
ISSN (electronic): 1464-5491
Publisher: Wiley-Blackwell
URL: http://dx.doi.org/10.1111/j.1464-5491.2004.01155.x
DOI: 10.1111/j.1464-5491.2004.01155.x
PubMed id: 15089784
Altmetrics provided by Altmetric
