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Lookup NU author(s): Emeritus Professor Brian Diffey, Professor Jonathan Rees
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The dynamics of human pigmentation in response to ultraviolet radiation (UVR) remain poorly characterized. In part, this is attributable to methodological issues relating to the overlap in spectra of hemoglobin and melanin. We describe a new method, based on the recording of reflectance properties following iontophoresis of a potent vasoconstrictor, noradrenaline. This removes the influence of blood, allowing measurement of pigmentation, represented as L* on the L*a*b* scale. Blood flow was separately assessed using laser Doppler flowmetry. We show that there is a clear dose response with the dose of UVR administered, that pigmentation peaks at 1 wk and declines over the following 10 wk, but does not return to baseline within this period. We show clear differences in the degree, but not the temporal pattern of pigmentation between different pigmentary groups. We also report that the relation between facultative pigment and constitutive pigment is incomplete, with a wide scatter of responses for the development of pigmentation irrespective of constitutive levels. For comparison we also document overall photoadaptation and relate changes in pigmentation to the overall changes in photoadaptation.
Author(s): Oh C, Hennessy A, Ha T, Bisset Y, Diffey B, Rees JL
Publication type: Article
Publication status: Published
Journal: Journal of Investigative Dermatology
Year: 2004
Volume: 123
Issue: 5
Pages: 965-972
ISSN (print): 0022-202X
ISSN (electronic): 1523-1747
Publisher: Nature Publishing Group
URL: http://dx.doi.org/10.1111/j.0022-202X.2004.23464.x
DOI: 10.1111/j.0022-202X.2004.23464.x
PubMed id: 15482486
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