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Depletion of MAP2 expression and laminar cytoarchitectonic changes in dorsolateral prefrontal cortex in adult autistic individuals

Lookup NU author(s): Dr Elizabeta Mukaetova-Ladinska, Helen Arnold, Dr Evelyn Jaros, Emeritus Professor Robert Perry, Emeritus Professor Elaine Perry

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Abstract

The neuropathological substrates underlying the characteristic clinical phenotype of autism are unknown. Neuroimaging studies have identified a decrease in task-related activation in the dorsolateral prefrontal cortex in autism. In the current study, we have analysed the dorsolateral prefrontal cortex in two adult individuals with a clinical diagnosis of autism, using Niss1 staining and MAP2 immunohistochemistry. There was unchanged density of both neuronal and glial cell pools, although the autistic individuals had ill-defined neocortical cellular layers, substantially depleted MAP2 neuronal expression, and reduced dendrite numbers. Further studies on a larger number of individuals with autism are needed to establish the clinical relevance of the described changes, especially to determine whether the loss of dendritic markers is age associated or disease specific.

Publication metadata

Author(s): Mukaetova-Ladinska EB, Arnold H, Jaros E, Perry R, Perry E

Publication type: Article

Publication status: Published

Journal: Neuropathology and Applied Neurobiology

Year: 2004

Volume: 30

Issue: 6

Pages: 615-623

Print publication date: 01/12/2004

ISSN (print): 0305-1846

ISSN (electronic): 1365-2990

Publisher: Wiley-Blackwell

URL: http://dx.doi.org/10.1111/j.1365-2990.2004.00574.x

DOI: 10.1111/j.1365-2990.2004.00574.x

PubMed id: 15541002

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