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Preparation of novel mesoporous carbons for the adsorption of an inflammatory cytokine (IL-1β)

Lookup NU author(s): Dr Nicholas Hoenich

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Abstract

Mesoporous carbons derived from two types of sulphonated styrene divinylbenzene copolymers (Macronet MN500HS and CT275, Purolite International Ltd) were produced and their adsorptive capacity for the proinflammatory cytokine IL-1β (MW 14.4kDa) determined. The carbons produced had surface areas from 400 to 1200m2g-1 and pore volume between 0.2 and 1.4cm3g-1. The mechanical strength of the carbon beads with surface area values up to 800m2g-1 were robust. The highest adsorption value of IL-1β was 150ngg-1 for a mesoporous carbon with surface area around 900m2g-1 and pore volume around 1.3cm3g-1. However, there was a trade-off between adsorptive capacity and mechanical strength. When used in conjunction with existing treatment modalities, the materials produced have the potential to enhance the removal of uraemic toxins. © 2003 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Malik DJ, Warwick GL, Venturi M, Streat M, Hellgardt K, Hoenich N, Dale JA

Publication type: Article

Publication status: Published

Journal: Biomaterials

Year: 2004

Volume: 25

Issue: 15

Pages: 2933-2940

ISSN (print): 0142-9612

ISSN (electronic): 1878-5905

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/j.biomaterials.2003.09.076

DOI: 10.1016/j.biomaterials.2003.09.076

PubMed id: 14967525

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