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Lookup NU author(s): Dr Louise VB Anderson
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Welander distal myopathy (WDM) is a late adult-onset autosomal dominant disorder, characterized by a slow progression and distal limb weakness of the extremity muscles. The WDM locus has been mapped to chromosome 2p13. Within this region a common shared haplotype co-segregates in all affected patients, indicating a founder effect. By undertaking an extended linkage analysis we have significantly reduced the WDM locus to a critical interval of approximately 1.2 Mb flanked by markers D2S358 and PAC3-H52. The dysferlin gene, a strong candidate gene responsible for two other distal myopathies in the same region, is located centromeric to PAC3-H52 and can thereby formally be excluded as cause for WDM.
Author(s): Von Tell D, Bruder CEG, Anderson LVB, Anvret M, Ahlberg G
Publication type: Article
Publication status: Published
Journal: Neurogenetics
Year: 2003
Volume: 4
Issue: 4
Pages: 173-177
ISSN (print): 1364-6745
ISSN (electronic): 1364-6753
Publisher: Springer
URL: http://dx.doi.org/10.1007/s10048-003-0154-z
DOI: 10.1007/s10048-003-0154-z
PubMed id: 12836053
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