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Lookup NU author(s): Dr Tibor Nyari, Dr Heather Dickinson, Donna Hammal, Professor Louise Parker
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In a retrospective cohort study of 673 787 live births in the Northern Region of England, 1975-1994, we investigated whether a higher level of population mixing around birth was a risk factor for solid tumours, by diagnostic group (Hodgkin's disease, brain and spinal tumours, neuroblastoma, other solid tumours), diagnosed during 1975-2001 under age 15 years. Logistic regression was used to relate risk to population mixing, based on (i) all movers and (ii) incomers from outside the region. Both ward and county district level analyses were performed. There was a decreased risk of brain and spinal tumours with increasing population mixing based on incomers from outside the region (OR for trend across three categories = 0.79, 95% CI: 0.66-0.95, P = 0.01 in the ward level analysis). Although this may be because of chance, it is consistent with a role of exposure to infection and immunological response in the aetiology of these turnouts. For other turnout groups, there was no consistent evidence of an association between risk and population mixing. © 2003 Cancer Research UK.
Author(s): Nyari TA, Dickinson HO, Hammal DM, Parker L
Publication type: Article
Publication status: Published
Journal: British Journal of Cancer
Year: 2003
Volume: 88
Issue: 9
Pages: 1370-1374
ISSN (print): 0007-0920
ISSN (electronic): 1532-1827
Publisher: Nature Publishing Group
URL: http://dx.doi.org/10.1038/sj.bjc.6600880
DOI: 10.1038/sj.bjc.6600880
PubMed id: 12778063
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