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Molecular development of the pancreatic β cell: Implications for cell replacement therapy

Lookup NU author(s): Dr Stephen Ball

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Abstract

Conventional insulin therapy is an imperfect treatment for diabetes mellitus, often failing to match insulin with prevailing blood glucose concentration. Accordingly, there is a drive for approaches such as β-cell replacement therapy, which is a permanent replacement for the lack of endogenous insulin production. The lack of cadaveric islets for transplantation determines that researchers must explore alternative sources of graft material. Cell engineering of non-β cells and selective expansion of stem cells are key potential sources. The past decade has witnessed an increase in our understanding of the molecular basis of pancreas and β-cell development. Our understanding of the molecular blueprint of how a β cell is made and maintained is crucial to realizing the potential of cell engineering and stem cell technologies in this area. This review outlines progress in this exciting field and high-lights the key role of development in guiding our appraisal of these new technologies.


Publication metadata

Author(s): Ball SG, Barber TM

Publication type: Review

Publication status: Published

Journal: Trends in Endocrinology and Metabolism

Year: 2003

Volume: 14

Issue: 8

Pages: 349-355

Print publication date: 01/10/2003

ISSN (print): 1043-2760

ISSN (electronic): 1879-3061

URL: http://dx.doi.org/10.1016/S1043-2760(03)00105-X

DOI: 10.1016/S1043-2760(03)00105-X

PubMed id: 14516932


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