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Botulinum toxin - Mechanisms of action and clinical use in spasticity

Lookup NU author(s): Professor Michael Barnes

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Abstract

Botulinum toxin is a potent neurotoxin produced by the bacterium Clostridium botulinum. There are seven serotypes, all of which block the release of acetylcholine from nerve endings, which gives the compound its theoretical base for reducing spasticity. Initial studies of the use of botulinum toxin in the management of spasticity were promising and now there are a number of well-designed, double-blind, placebo-controlled studies that confirm the place of botulinum toxin in our treatment armoury against focal spasticity. The studies have demonstrated both efficacy and safety. There is still more work to be done in terms of disability although early reports confirm functional improvements, particularly reduction of pain as well as improvements in nursing care, hygiene and carer burden. Further studies also need to be done to confirm the place of botulinum toxin in the overall context of other treatment possibilities in the management of spasticity.


Publication metadata

Author(s): Barnes M

Publication type: Article

Publication status: Published

Journal: Journal of Rehabilitation Medicine

Year: 2003

Issue: 41

Pages: 56-59

Print publication date: 01/01/2003

ISSN (print): 1650-1969

ISSN (electronic): 1650-1977

Publisher: Taylor & Francis

URL: http://dx.doi.org/10.1080/16501960310010151

DOI: 10.1080/16501960310010151

PubMed id: 12817658


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