Browse by author
Lookup NU author(s): Dr Nicholas Hoenich
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Background: Statistical associations between urea removal and survival have been described in a number of publications. Urea removal during treatment may be quantified by the delivered dose of dialysis. Methods in clinical use to measure delivered dose are retrospective and reliant on accurate blood sampling. The new generation of single patient proportionating systems incorporate the facility to automatically measure ionic dialysance throughout dialysis. Methods: In a prospective study on 9 anuric patients with a stable dialysis prescription, we have compared the agreement of the dose of dialysis determined from ionic dialysance (Dt/V) with that derived from equilibriated Kt/V (eKt/V) and Kt/V measured by direct dialysis quantification (Kt/VDDQ) using 2 types of hemodialysis membrane (hemophan and low-flux polysulfone). The variability of the delivered dose over a 1-month period was also determined. Results: Ionic dialysance was independent of membrane type. It was comparable to that established for plasma urea water clearance for hemophan but lower for polysulfone (p < 0.001). The mean (± SD) delivered dose of dialysis (Dt/V) was similar for both membranes (1.18 ± 0.15 (hemophan) and 1.18 ± 0.11 (low-flux polysulfone)). Bland Altman comparisons showed the limits of agreement between Dt/V and Kt/VDDQ were ± 0.17 and for Dt/V compared with eKt/V ± 0.15. A 1-month measurement of Dt/V demonstrated considerable treatment to treatment variability indicating that delivered dose cannot be considered stable. Conclusion: The availability of online measurement of ionic dialysance provides a step towards monitoring dialysis more closely at the time of delivery, and its clinical application will ensure that a more constant dialysis dose is delivered.
Author(s): Katopodis KP, Hoenich NA
Publication type: Article
Publication status: Published
Journal: Clinical Nephrology
Year: 2002
Volume: 57
Issue: 3
Pages: 215-220
Print publication date: 01/01/2002
ISSN (print): 0301-0430
ISSN (electronic):
Publisher: Dustri-Verlag Dr. Karl Feistle
PubMed id: 11924753
