Toggle Main Menu Toggle Search

Open Access padlockePrints

Association of the signaling adaptor FRS2 with fibroblast growth factor receptor 1 (FGFR1) is mediated by alternative splicing of the juxtamembrane domain

Lookup NU author(s): Joanna Elsden

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Fibroblast growth factor receptors (FGFRs) are a family of transmembrane tyrosine kinases involved in signaling via interactions with the family of fibroblast growth factors. Alternative splicing of the juxtamembrane region of FGFR1-3 leads to the inclusion or exclusion of two amino acids, valine and threonine, the VT site. The presence or absence of VT (VT+ or VT-, respectively) affects the signaling potential of the receptor. The VT+ receptor isoform is required for Erk2 phosphorylation, a component of the mitogen-activated protein kinase signaling pathway. FRS2 is an adaptor protein that links FGFRs to the mitogen-activated protein kinase signaling pathway. FRS2 interacts with a region of the juxtamembrane domain of FGFR1 that includes the alternatively spliced VT site. We investigated the interaction of FRS2 with murine Fgfr1 juxtamembrane domain. We showed the alternatively spliced VT motif, at the juxtamembrane domain of Fgfr1 is required for FRS2 interaction with Fgfr1. Activation of signaling pathways from FRS2 is likely to be regulated by controlling the Fgfr1/FRS2 interaction through alternative splicing of the VT motif of Fgfr1.


Publication metadata

Author(s): Burgar HR, Burns HD, Elsden JL, Lalioti MD, Heath JK

Publication type: Article

Publication status: Published

Journal: Journal of Biological Chemistry

Year: 2002

Volume: 277

Issue: 6

Pages: 4018-4023

ISSN (print): 0021-9258

ISSN (electronic): 1083-351X

Publisher: American Society for Biochemistry and Molecular Biology, Inc.

URL: http://dx.doi.org/10.1074/jbc.M107785200

DOI: 10.1074/jbc.M107785200

PubMed id: 11729184


Altmetrics

Altmetrics provided by Altmetric


Share