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Lookup NU author(s): Professor David Samuels, Dr Enid Michael, Emeritus Professor Doug Turnbull, Professor Patrick Chinnery
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We measured the proportion of mutant mtDNA (mutation load) in 82 primary oocytes from a woman who harbored the A3243G mtDNA mutation. The frequency distribution of mutation load indicates that random drift is the principal mechanism that determines the level of mutant mtDNA within individual oocytes.
Author(s): Brown DT, Samuels DC, Michael EM, Turnbull DM, Chinnery PF
Publication type: Article
Publication status: Published
Journal: American Journal of Human Genetics
Year: 2001
Volume: 68
Issue: 2
Pages: 533-536
Print publication date: 01/01/2001
ISSN (print): 0002-9297
ISSN (electronic): 1537-6605
Publisher: Cell Press
URL: http://dx.doi.org/10.1086/318190
DOI: 10.1086/318190
PubMed id: 11133360
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