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Lookup NU author(s): Professor Carlos Hormaeche
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A live attenuated Salmonella typhimurium vaccine candidate, LVR01, was constructed by introducing a null deletion into the aroC gene of the parental canine S. typhimurium isolate, P228067. LVR01 was used to orally deliver to the canine immune system a fatty acid binding protein (FABP) from Echinococcus granulosus (EgDf1), as a fusion protein with fragment C (TetC) of tetanus toxin. Immunization studies demonstrated that live LVR01 is well tolerated by orally vaccinated dogs. There was no detectable shedding of the vaccine strain in the faeces 2 days after immunization. Humoral antibody responses were observed against Salmonella, TetC and EgDf1. Cellular responses were consistently detected against Salmonella and TetC. A cellular response against EgDf1 was also seen in a proportion of the LVR01 vaccinated dogs. We propose S. typhimurium LVR01 as a carrier for recombinant antigens and a vector for the construction of multivalent oral vaccines for dogs. (C) 2000 Elsevier Science Ltd.
Author(s): Chabalgoity JA, Moreno M, Carol H, Dougan G, Hormaeche CE
Publication type: Article
Publication status: Published
Journal: Vaccine
Year: 2000
Volume: 19
Issue: 4-5
Pages: 460-469
ISSN (print): 0264-410X
ISSN (electronic): 1873-2518
Publisher: Elsevier
URL: http://dx.doi.org/10.1016/S0264-410X(00)00197-3
DOI: 10.1016/S0264-410X(00)00197-3
PubMed id: 11027809
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