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Can cord blood cells support the cytokine storm in GvHD?

Lookup NU author(s): Dr Xiao WangORCiD, Professor Anne Dickinson

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Abstract

Cord blood has a high number of proliferating hematopoietic progenitors and is therefore used as an alternative source of hematopoietic cells for allogeneic transplantation. In addition there is a wider availability of cord blood and a lower cost of procurement compared to bone marrow. However one of the most interesting immunological benefits of a cord blood transplant that has been proposed is the low severity of Graft versus Host Disease (GvHD). This review aims to address some of the immunological reasons why this may be the case by assessing the role of cord blood cytokines in the cytokine storm of GvHD. (C) 2000 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Cohen SBA, Wang XN, Dickinson A

Publication type: Note

Publication status: Published

Journal: Cytokine and Growth Factor Reviews

Year: 2000

Volume: 11

Issue: 3

Pages: 185-197

ISSN (print): 1359-6101

ISSN (electronic): 1879-0305

URL: http://dx.doi.org/10.1016/S1359-6101(00)00004-6

DOI: 10.1016/S1359-6101(00)00004-6

PubMed id: 10817962

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