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Lookup NU author(s): Dr Nicholas Hoenich
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The solute transport characteristics and biocompatibility of a new polysulfone membrane (Polysulfone LS, Fresenius Medical Care, Bad Homburg, Germany) has been established and compared for two different sizes of dialyser (1.3 and 1.8 m2). The in vivo small molecular clearance of the two sizes of dialyser showed an overlap in performance. Neutropenia was slight and independent of the membrane areas as were changes in C5a(des Arg). The membrane induced neutrophil degranulation characterised by the release of elestase α1 inhibitor complex with time averaged values over 180 minutes related to membrane area (p=0.010). Heparin activity during dialysis with the membrane was within the therapeutic range necessary for anticoagulation (0.3-1.0 IU/ml), but despite this an increase in thrombin antithrombin III levels during treatment was noted. Polysulfone LS extends the range of polysulfone membranes available for clinical use and its performance in such that it may be considered as a membrane for the treatment of patients awaiting a transplant, or in whom use of the high flux therapies may be inappropriate.
Author(s): Hoenich NA
Publication type: Article
Publication status: Published
Journal: International Journal of Artificial Organs
Year: 2000
Volume: 23
Issue: 6
Pages: 365-370
ISSN (print): 0391-3988
ISSN (electronic): 1724-6040
Publisher: Wichtig Editore Srl
URL: http://www.ncbi.nlm.nih.gov/pubmed/10919753
PubMed id: 10919753
