Browse by author
Lookup NU author(s): Dr Quentin Campbell Hewson, Professor Penny Lovat, Professor Archibald Malcolm, Professor Andrew Pearson, Dr Chris RedfernORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The aim of this study was to clarify retinoid receptor mechanisms mediating the effects of 9-cis retinoic acid (RA) and investigate the ability of RAR- and RXR-specific analogues to induce differentiation and inhibit proliferation in neuroblastoma cells. Differentiation and the inhibition of proliferation by 9-cis RA, but not all-trans RA, were inhibited by the RXR-homodimer antagonist LG745. The RXR-specific agonist LGD1069 was ineffective at inducing differentiation or inhibiting proliferation, but showed marked synergism with RAR-specific agonists with respect to inhibiting proliferation. These data suggest that the effects of 9-cis RA are mediated via both RXR-homodimers and heterodimers. However, combinations of RAR- and RXR-selective analogues were not as effective at promoting differentiation. This study indicates that different receptor mechanisms are involved in retinoid-induced differentiation and inhibition of proliferation in neuroblastoma cells. Copyright (C) 2000 Elsevier Science Ireland Ltd.
Author(s): Campbell-Hewson, Q., Lovat, P.E., Malcolm, A.J., Pearson, A.D.J., Redfern, C.P.F.
Publication type: Article
Publication status: Published
Journal: Neuroscience Letters
Year: 2000
Volume: 279
Issue: 2
Pages: 113-116
Print publication date: 28/01/2000
ISSN (print): 0304-3940
ISSN (electronic): 1872-7972
URL: http://dx.doi.org/10.1016/S0304-3940(99)00956-8
DOI: 10.1016/S0304-3940(99)00956-8
PubMed id: 10674634
Altmetrics provided by Altmetric