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Jumping translocation at 11q23 with MLL gene rearrangement and interstitial telomeric sequences

Lookup NU author(s): Gavin Cuthbert, Dr Nicholas Bown

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Abstract

We report a case of acute myeloid leukemia (AML) M5a showing a jumping translocation with a breakpoint at 11q23. Fluorescence in situ hybridization (FISH) demonstrated triplication of the MLL gene and the presence of interstitial telomeric sequences, supporting the role of repetitive sequences in the mechanism of jumping translocations. Southern blot analysis of the MLL breakpoint cluster region showed the presence of an MLL gene rearrangement. Jumping translocation with MLL gene rearrangement is a previously unreported phenomenon in leukemia cytogenetics.

Publication metadata

Author(s): Cuthbert G, McCullough S, Finney R, Breese G, Bown N

Publication type: Article

Publication status: Published

Journal: Genes, Chromosomes and Cancer

Year: 1999

Volume: 24

Issue: 4

Pages: 295-298

Print publication date: 01/04/1999

ISSN (print): 1045-2257

ISSN (electronic): 1098-2264

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/(SICI)1098-2264(199904)24:4<295::AID-GCC1>3.0.CO;2-8

DOI: 10.1002/(SICI)1098-2264(199904)24:4<295::AID-GCC1>3.0.CO;2-8

PubMed id: 10092126

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