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Insulin-like growth factor binding protein-3 in breast cyst fluid: Relationships with insulin-like growth factors I and II and transforming growth factor-beta 1 and 2

Lookup NU author(s): Professor Thomas Lennard

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Abstract

Women who have palpable breast cysts with intracystic Na/K > 3 may have a lower risk of developing breast cancer than those with intracystic Na/K < 3. In this study significantly higher concentrations of insulin-like growth factor-binding protein-3 (IGFBP-3), insulin-like growth-factors I and II (IGF-I, IGF-II) and transforming growth factor-beta 2 (TGF-β2) were found in the Na/K > 3 sub-group. No difference was found in transforming-growth factor-beta 1 (TGF-β1) levels between the two sub-groups of breast cysts. A positive correlation was obtained for IGFBP-3 and TGF-β1 in the Na/K > 3 sub-group consistent with reports that TGF-β1 may regulate the production of IGFBP-3. Equimolar amounts of total IGFs and IGFBP-3 in breast cyst fluid imply that most, if not all, of these IGFs are protein-bound. The significantly higher concentrations of TGF-β2 in the Na/K > 3 sub-group may partly explain the lower risk of breast cancer in this group of women.


Publication metadata

Author(s): Lai L, Erbas H, Meadows K, Lennard TWJ, Holly J

Publication type: Article

Publication status: Published

Journal: Cancer Letters

Year: 1996

Volume: 110

Issue: 1-2

Pages: 207-212

Print publication date: 20/12/1996

ISSN (print): 0304-3835

ISSN (electronic): 1872-7980

URL: http://dx.doi.org/10.1016/S0304-3835(96)04497-7

DOI: 10.1016/S0304-3835(96)04497-7

PubMed id: 9018103


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