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Lookup NU author(s): Dr Ian HardcastleORCiD
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A novel diphosphate mimic, the 2,3,6-trifluoro-5-hydroxy-4-nitrophenoxy group (1), has been employed as the template in the solid-phase synthesis of novel Farnesyl Transferase inhibitors using the Mitsunobu reaction. The most potent inhibitor (farnesyloxy-5-hydroxy-2,3,6-trifluoro-4-nitrobenzene) displayed an IC50 of 6.3 μM versus Farnesyl Transferase.
Author(s): Barber AM, Hardcastle IR, Rowlands MG, Nutley BP, Marriott JH, Jarman M
Publication type: Article
Publication status: Published
Journal: Bioorganic & Medicinal Chemistry Letters
Year: 1999
Volume: 9
Issue: 4
Pages: 623-626
Print publication date: 09/04/1999
ISSN (print): 0960-894X
ISSN (electronic): 1464-3405
Publisher: Pergamon
URL: http://dx.doi.org/10.1016/S0960-894X(99)00043-8
DOI: 10.1016/S0960-894X(99)00043-8
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