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Lookup NU author(s): Dr Stephan Gruber
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Chromosome segregation during mitosis and meiosis depends on the linkage of sister DNA molecules after replication. These links, known as sister-chromatid cohesion, are provided by a multi-subunit complex called cohesin. Recent papers suggest that chromatin-remodeling complexes also have a role in the generation of sister-chromatid cohesion. It remains unclear whether they do so by facilitating the recruitment of cohesin to specific chromosomal sequences or by modifying an event at replication forks giving rise to cohesion between sister DNAs.
Author(s): Gruber S; Riedel CG; Gregan J; Nasmyth K
Publication type: Article
Publication status: Published
Journal: Trends in Biochemical Sciences
Year: 2004
Volume: 29
Issue: 8
Pages: 389-392
ISSN (print): 0968-0004
ISSN (electronic): 0167-7640
Publisher: Elsevier Ltd.
URL: http://dx.doi.org/10.1016/j.tibs.2004.06.007
DOI: 10.1016/j.tibs.2004.06.007
Notes: Journal Article Research Support, Non-U.S. Gov't Review England
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