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Lookup NU author(s): Dr Urs Mosimann
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The study investigated the influence of double-pulse transcranial magnetic stimulation (dTMS) on memory-guided saccade triggering. Double pulses with interstimulus intervals (ISIs) of 35, 50, 65 or 80 ms were applied over the right frontal eye field (FEF) and as control over the occipital cortex. A significant dTMS effect was found exclusively for contralateral saccades; latency of memory-guided saccades was reduced after FEF stimulation with an ISI of 50 ms compared to latency without stimulation. This effect proved to be specific for the ISI of 50 ms over the FEF because control stimulation with the same ISI over the occipital cortex had no significant effect on latency of memory-guided saccades. The results of our study showed that, by using an appropriate ISI, dTMS is able to facilitate contralateral saccade triggering by stimulating the FEF. This suggests that TMS interferes specifically with saccade triggering mechanisms, probably by acting on presaccadic neurons of the FEF.
Author(s): Mosimann UP; Wipfli M; Felblinger J; Hess CW; Schlaepfer TE; Muri RM
Publication type: Article
Publication status: Published
Journal: European Journal of Neuroscience
Year: 2001
Volume: 14
Issue: 3
Pages: 571-575
ISSN (print): 0953-816X
ISSN (electronic): 1460-9568
Publisher: Wiley-Blackwell Publishing Ltd.
URL: http://dx.doi.org/10.1046/j.0953-816x.2001.01671.x
DOI: 10.1046/j.0953-816x.2001.01671.x
PubMed id: 11553308
Notes: 0953-816X (Print) Clinical Trial Journal Article
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